Dr Nathan Hall

Senior Bioinformatician

Faculty of Science, Technology and Engineering

School of Molecular Sciences La Trobe Institute for Molecular Science

Rm 103 PS4, Melbourne (Bundoora)

 

Qualifications

BSc(Hons), PhD

Brief Profile

Nathan is a Senior Research Scientist in the field of bioinformatics and is joint funded by La Trobe University and the Life Sciences Computation Centre at the VLSCI.  He is working with researchers across the Life Sciences and Molecular Sciences Schools at La Tribe University on the design and analysis of Next-generation sequencing experiments.

 

Recent Publications

 

  1. Gregory KJ, Hall NE, Tobin AB, Sexton PM, Christopoulos A. Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem.2010 285(10):7459-74
  2. Simms J, Hall NE, Lam PH, Miller LJ, Christopoulos A, Abagyan R, Sexton PM. Homology modeling of GPCRs.Methods Mol Biol. 2009 552:97-113.
  3. de Jong-Curtain TA, Parslow AC, Trotter AJ, Hall NE, Verkade H, Tabone T, Christie EL, Crowhurst MO, Layton JE, Shepherd IT, Nixon SJ, Parton RG, Zon LI, Stainier DY, Lieschke GJ, Heath JK. Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology 2009 136(3):902-11
  4. Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand. J Biol Chem. 2008 283(43):29312-21
  5. Kowadlo G, Hall NE, Burgess AW. De novo design of beta-helical polypeptides. Growth Factors 2007 25(3):168-90.
  6. Layton JE, Hall NE. The Interaction of G-CSF with its receptor. Frontiers in Bioscience 2006 31(3):177-99.
  7. Hogan BM, Pase L, Hall NE, Lieschke GJ. Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish. Dev Genes Evol. 2006 216(9):523-9
  8. King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM. Eve-3: A liver enriched suppressor of Ras/MAPK signaling. J Hepatol. 2006 44(4):758-67
  9. King JA, Straffon AF, D'Abaco GM, Poon CL, I ST, Smith CM, Buchert M, Corcoran NM, Hall NE, Callus BA, Sarcevic B, Martin D, Lock P, Hovens CM. Distinct requirements for the Sprouty domain for functional activity of Spred proteins. Biochem J. 2005 388(Pt 2):445-54.
  10. Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, Lieschke GJ. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol. 2004 276(2):508-22.
  11. IST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, Randazzo PA, Lock P. ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. J Cell Sci. 2004 117(Pt 25):6071-84.
  12. Hogan BM, Danks JA, Layton JE, Hall NE, Heath JK, Lieschke GJ. Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis. Endocrinology 2005 146(2):547-51.
  13. Johns TG, Adams TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ, Kim YS, Rothacker J, Nice EC, Walker F, Ritter G, Jungbluth AA, Old LJ, Ward CW, Burgess AW, Wittrup KD, Scott AM. Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. J Biol Chem. 2004 279(29):30375-84
  14. Walker F, Orchard SG, Jorissen RN, Hall NE, Zhang HH, Hoyne PA, Adams TE, Johns TG, Ward C, Garrett TP, Zhu HJ, Nerrie M, Scott AM, Nice EC, Burgess AW. CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor. J Biol Chem. 2004 279(21):22387-98.
  15. Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ. Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain. Proc Natl Acad Sci U S A 200299(25):15959-64.
  16. Taverner T, Hall NE, O'Hair RA, Simpson RJ. Characterization of an antagonist interleukin-6 dimer by stable isotope labeling, cross-linking, and mass spectrometry. J Biol Chem. 2002 277(48):46487-92.
  17. Lieschke GJ, Oates AC, Paw BH, Thompson MA, Hall NE, Ward AC, Ho RK, Zon LI, Layton JE. Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol. 2002 246(2):274-95.
  18. Layton JE, Hall NE, Connell F, Venhorst J, Treutlein HR. Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor. J Biol Chem. 2001276(39):36779-87.
  19. Scholz GM, Cartledge K, Hall NE. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. J Biol Chem. 2001 276(33):30971-9.
  20. Baldwin ME, Catimel B, Nice EC, Roufail S, Hall NE, Stenvers KL, Karkkainen MJ, Alitalo K, Stacker SA, Achen MG. The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. J Biol Chem. 2001 276(22):19166-71.
  21. Moritz RL, Hall NE, Connolly LM, Simpson RJ. Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130. J Biol Chem. 2001 276(11):8244-53.

Older Publications

 

  1. Johnstone CN, Tebbutt NC, Abud HE, White SJ, Stenvers KL, Hall NE, Cody SH, Whitehead RH, Catimel B, Nice EC, Burgess AW, Heath JK. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000 (3):G500-10.
  2. Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL. p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck. Mol Cell Biol. 2000 20(18):6984-95.
  3. Cole AR, Hall NE, Treutlein HR, Eddes JS, Reid GE, Moritz RL, Simpson RJ. Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor. J Biol Chem. 1999274(11):7207-15.
  4. Smith BJ & Hall NE Atomic Radii: Incorporation of Solvation Effects. J. Comput. Chem. 1998 19, 1482-1493.
  5. Hall NE & Smith BJ High-Level ab initio Molecular Orbital Calculations of Imine Formation.J. Phys. Chem. A 1998102, 4930-4938.
  6. Hall NE & Smith BJ Solvation Effects on Zwitterion Formation. J. Phys. Chem. A 1998 102, 3985-3990.
  7. Smith BJ & Hall NE G2(MP2,SVP) study of the relationship between the benzyl and tropyl radicals, and their cation analogues. Chem. Phys. Lett.1997 279, 165-171.
  8. Lawrence MC, Barbosa JARG, Smith BJ, Hall NE, Pilling PA, Ooi HC, Marcuccio SM Structure and Mechanism of a Sub-family of Enzymes Related to N-Acetylneuraminate Lyase. J. Mol. Biol. 1997 266, 381-399.
  9. Harcourt RD & Hall NE Some ab initio valence bond studies of N2O and CO2. J. Mol. Struct. (Theochem) 1995 342, 59-71.