Associate Professor, Reader
Faculty of Science, Technology and Engineering
School of Molecular SciencesPhysical Science 4 room 372/374 (L), Melbourne (Bundoora)
BSc GLAS., PhD DUND.
Biotechnology
Mick completed his Bachelor of Science degree in microbiology at Glasgow College of Technology in 1982 and embarked on a PhD in biophysics of parasitic helminths with Prof. Peter Garland in the Department of Biochemistry, University of Dundee. Upon completion of his PhD he was awarded a Wellcome Training Fellowship and worked with Dr Robin Anders in the Immunoparasitology group at the Walter and Elisa Hall Institute on malaria, particularly the molecular biology of the host parasite interface. After a couple of years as a Wellcome Research Fellow in David Wallikers group at the University of Edinburgh, Mick returned to the Department of Biochemistry at La Trobe University where he worked with Leann Tilley on the mechanism of action of anti-malarial drugs. During his time in Edinburgh he carried out a field trip to the Sudan and later in 1994 he visited Mongolia as an International Atomic Energy Agency (IAEA) expert scientist. In 1995 he was awarded an ARC QEII Fellowship where he established the phage display of antibodies and peptide technology as a means of unlocking the secrets of the invasion of malaria parasites into red blood cells.
Mick is a project leader and member in the Cooperative Research Centre for Biomarker translation where his group are producing monoclonal antibodies for a variety of disease conditions. The group is also using phage display to epitope mapping of these bioactive antibodies. In 2004 Mick was promoted to Associate Professor/Reader. He has received support for his research from National Health and Medical Research, Australian Research Council, World Health Organisation and the National Institutes fo Health (USA) and has been funded since 1994 by the CRC scheme. Recently the lab has had funding from the Malaria Vaccine Initiative and USAID. Currently he is Cheif Scientific Officer for AdAlta Pty.Ltd. Mick was born in Scotland his interests are Golf (where he sometimes lets Robin Anders win), and Glasgow Celtic - the greatest football team the Universe has ever seen.
Mick is involved in teaching Energy Metabolism and Lipid Metabolism in the second year Biochemistry course (BCH2MBC Metabolic Biochemistry & Cell Biology). He is also involved in teaching Gene Technology to the third year Biochemistry course (BCH3BMA Advanced Topics in Biochemistry & Molecular Biology).
Mick is part time Chief Scientific Officer for AdAlt.Pty.Ltd
1. M, Masciantonio R, Sabo JK, Keizer DW, Lee EF, McMahon A, Norton RS, Anders RF, FOLEY M. (2005) Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1. Infect Immun. 73, 6981-9.
2. Casey JL, Coley AM, Street G, Parisi K, Devine PL, FOLEY M. (2006) Peptide mimotopes selected from a random Peptide library for diagnosis of Epstein-Barr virus infection. J Clin Microbiol. 44, 764-71.
3. Coley AM, Parisi K, Masciantonio R, Hoeck J, Casey JL, Murphy VJ, Harris KS, Batchelor AH, Anders RF, FOLEY M. (2006). The most polymorphic residue on Plasmodium falciparum AMA1 determines binding of an invasion-inhibitory antibody. Infect Immun 74, 2628-2636.
4. Casey JL, Coley AM and FOLEY M. (2007) Phage display of peptides in ligand selection for use in affinity chromatography. In Affinity Chromatography: Methods and Protocols, Second Edition, THE HUMANA PRESS INC. Methods Mol Biol. 421:111-24
5. Sabo JK, Keizer DW, Feng ZP, Casey JL, Parisi K, Coley AM, FOLEY M, Norton RS. (2007) Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue. Infect. Immun. 75, 61-73.
6. A.M. Coley, A. Gupta, V.J. Murphy, T. Bai, H. Kim, R. F. Anders, M. FOLEY* and A. H. Batchelor*. (2007) Crystal structure of a parasite growth-inhibitory antibody in complex with the malaria antigen AMA1 from Plasmodium falciparum. PLoS Pathogens. 3, 1308-19. [Joint corresponding authors]
7. K.A. Henderson, V.A. Streltsov, A.M. Coley, O. Dolezal, A. H. Batchelor, A. Gupta, T. Bai, V. J. Murphy, R. F. Anders, M. FOLEY* and S. D. Nuttall. (2007) Structure. Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition. Structure. 15, 1452-66. [Joint corresponding authors]
8. D.P. Simmons V.A Streltsov, O. Dolezal, P. J. Hudson, A. M Coley, M FOLEY, D. F. Proll and S. D. Nuttall.(2008) Shark IgNAR Antibody Mimotopes Target a Murine Immunoglobulin through Extended CDR3 Loop Structures. PROTEINS: Structure, Function, and Bioinformatics. 71, 119-30.
9. H. Tschiggerl, J.L. Casey, K. Parisi, M. FOLEY M, and U.B Sleytr. (2008) Display of a peptide mimotope on a crystalline bacterial cell surface layer (S-layer) lattice for diagnosis of Epstein-Barr virus infection. Bioconjug Chem. 19,860-5.
10. Casey JL, Coley AM, Parisi K, FOLEY M. (2008) Peptide mimics selected from immune sera using phage display technology can replace native antigens in the diagnosis of Epstein–Barr virus infection. Protein Engineering, Design & Selection. 22, 85-91
11. Read AJ, Casey JL, Coley AM, FOLEY M, Gauci CG, Jackson DC, Lightowlers MW. (2009) Isolation of antibodies specific to a single conformation-dependant antigenic determinant on the EG95 hydatid vaccine. Vaccine. 27, 1024-31
12. Harris KS, Casey JL, Coley AM, Karas JA, Sabo JK, Tan YY, Dolezal O, Norton RS, Hughes AB, Scanlon D, FOLEY M. (2009) Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning. Journal of Biological Chemistry. 284, 9361-71.
13. Adda CG, Murphy VJ, Sunde M, Waddington LJ, Schloegel J, Talbo GH, Vingas K, Kienzle V, Masciantonio R, Howlett GJ, Hodder AN, FOLEY M, Anders RF. (2009) Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils. Mol. Biochem. Parasitol.166, 159-171
14. Anders RF, Adda CG, FOLEY M, Norton RS. (2010) Recombinant protein vaccines against the asexual blood-stages of Plasmodium falciparum. Hum. Vaccine. 6, 39-53.
15. Richard D, Macraild CA, Riglar DT, Chan JA, FOLEY M, Baum J, Ralph SA, Norton RS, Cowman AF. (2010) Interaction between plasmodium falciparum apical membrane antigen 1 and the Rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites. J Biol Chem. 285, 14815-22.
16. Lee EF, Yao S, Sabo JK, Fairlie WD, Stevenson RA, Harris KS, Anders RF, FOLEY M, Norton RS. (2011) Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues. Biopolymers. 95, 354-64.
17. Donker NC, FOLEY M, Tamvakis DC, Bishop R, Kirkwood CD. (2011) Identification of an antibody-binding epitope on the rotavirus A non-structural protein NSP2 using phage display analysis. J Gen Virol. 92, 2374-82.
18. Macraild CA, Anders RF, FOLEY M, Norton RS. (2011) Apical membrane antigen 1 as an anti-malarial drug target. Curr Top Med Chem. 11, 2039-47.
19. Casey JL, Sanalla AM, Tamvakis D, Thalmann C, Carroll EL, Parisi K, Coley AM, Stewart DJ, Vaughan JA, Michalski WP, Luke R, FOLEY M. (2011) Peptides specific for Mycobacterium avium subspecies paratuberculosis infection: diagnostic potential. Protein Eng Des Sel. 24, 589-96