Dr Anne E

Dr Anne E Holland


College of Science, Health and Engineering

School of Allied Health

Department of Rehabilitation, Nutrition and Sport

Alfred Health Clinical School,


BAppSc, PhD



Area of study


Brief profile

Anne Holland leads a research program that aims to optimise health and wellbeing for people with cardiorespiratory disease, based at the Alfred Health Clinical School. Anne’s research is investigating new models for pulmonary rehabilitation, including low cost home-based models and telerehabilitation, as well as defining the benefits of pulmonary rehabilitation in new populations such as interstitial lung disease. She has over 130 publications in peer reviewed journals related to chronic respiratory disease and rehabilitation. Her publications have been cited over 2300 times, including in 8 national and international treatment guidelines. Anne has received over $AUD 5million in competitive research funding since 2003.

Anne's role is to lead and grow the physiotherapy clinical research program at Alfred Health, where she provides supervision and mentoring to clinicians and students undertaking research projects in a clinical setting.

Research interests

Chronic disease

- Chronic respiratory disease


- Pulmonary rehabilitation

Recent publications

Holland AE. Functional capacity in idiopathic pulmonary fibrosis: looking beyond the lungs (Editorial). Respirology 2015; 20 (6): 857-858.

Kimmel L, Elliot J, Sayer J, Holland AE. Assessing the reliability and validity of a physiotherapy functional measurement tool, the modified Iowa Level of Assistance scale, in acute hospital inpatients. Physical Therapy, In Press, accepted 21st May 2015.

Granger C, Gordon I, Holland AE, Denehy L. Minimal important difference of the six-minute walk distance in lung cancer. Chronic Respiratory Disease 2015; 12(2):146-54.

Andrianopoulos V, Holland AE, Singh SJ, Franssen FME, Pennings H, Michels AJ, Smeenk FWJM, Vogiatzis I, Wouters EFM and Spruit MA. Six minute walk distance in patients with COPD: which reference equations should we use? Chronic Respiratory Disease 2015; 12(2):111-9.

Chan K, Poh E, Denehy L, Elliot D, Holland AE, Dinglas B, Needham D. Construct Validity and Minimal Important Difference of 6-Minute Walk Distance in Survivors of Acute Respiratory Failure. Chest; In Press, accepted 3rd January 2015.

Holland AE, Fiore Jr JF, Goh N, Symons K, Dowman L, Westall G, Hazard A, Glaspole I. Be honest and help me prepare for the future: what people with interstitial lung disease want from education in pulmonary rehabilitation. Chronic Respiratory Disease 2015; 12(2):93-101.

Chang AB, Bell SC, Torzillo PJ, King PT, Byrnes CA, Maguire GP, Holland AE, O’Mara P. Grimwood K, and the extended voting group. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand: TSANZ Guidelines. Medical Journal of Australia 2015; 202(1): 21-3.

Holland AE. Physiotherapy management of acute exacerbations of chronic obstructive pulmonary disease. Journal of Physiotherapy 2014; 60: 181-88.

Dowman L, Hill CJ, Holland AE. Pulmonary rehabilitation for interstitial lung disease. Cochrane Database of Systematic Reviews 2014; Oct 6;10:CD006322. doi: 10.1002/14651858.CD006322.pub3

Cox NS, Alison JA, Button BM, Wilson JW, Holland AE. Feasibility and acceptability of an internet based program to promote physical activity in people with cystic fibrosis. Respiratory Care 2015; 60(3):422-9.

Holland AE, Rasekaba T, Fiore JF, Burge AT, Lee AL. The The 6-minute walk distance cannot be accurately assessed at home in people with COPD. Disability and Rehabilitation 2014; Sep 1:1-5.

Holland AE, Spruit MA, Troosters T, Puhan MA, Pepin V, Saey D, McCormack MC, Carlin BW, Sciurba FC, Pitta F, Wanger J, MacIntyre N, Kaminsky DA, Culver BH, Revill SM, Hernandes NA, Andrianopoulos V, Camillo CA, Mitchell KE, Lee AL, Hill CJ, Singh SJ. An Official European Respiratory Society / American Thoracic Society Technical Standard: Field Walking Tests in Chronic Respiratory Disease. European Respiratory Journal 2014; 44(6):1428-46.

Singh SJ, Puhan MA, Andrianopoulos V, Hernandes NA, Mitchell KE, Hill CJ, Lee AL, Camillo CA, Troosters T, Spruit MA, Carlin BW, Wanger J, Pepin V, Saey D, Pitta F, Kaminsky DA, McCormack MC, MacIntyre N, Culver BH, Scuirba FC, Revill SM, Delafosse V, Holland AE. An Official Systematic Review of the European Respiratory Society / American Thoracic Society: Measurement properties of field walking tests in chronic respiratory disease. European Respiratory Journal 2014; 44(6):1447-78.

Lee AL, Hill CJ, Cecins N, Jenkins SJ, McDonald CF, Burge AT, Rautela L, Stirling RG, Thompson PJ, Holland AE. Minimal important difference for field walking tests in non-cystic fibrosis bronchiectasis following exercise training. Respiratory Medicine 2014; 108: 1303 – 1309.

Holland AE, Fiore JF Jr, Bell EC, Goh N, Westall G, Symons K, Dowman L, Glaspole I. Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease. Respirology 2014 Nov;19(8):1215-21.

Holland AE, Dowman L, Fiore JF JR, Brazzale D, Hill CJ, McDonald CF. Cardiorespiratory responses to 6-minute walk test in interstitial lung disease: not always a submaximal test. BMC Pulmonary Medicine 2014; 14:136. DOI: 10.1186/1471-2466-14-136

Heng H, Lee AL, Holland AE. Repeating pulmonary rehabilitation: prevalence, predictors and outcomes. Respirology 2014; 19(7):999-1005.

O’Halloran P, Blackstock F, Shields N, Holland AE, Iles R, Kingsley R, Bernhard J, Lannin N, Morris ME, Taylor N. Motivational interviewing to increase physical activity and fitness in people with health conditions: a systematic review. Clinical Rehabilitation 2014;28(12):1159-71.

Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, Rautela L, Stirling RG, Thompson PJ, Holland AE. The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis – a randomised controlled trial. Respiratory Research 2014, 15(1):44.

Fuller LM, Button B, Tarrant B, Battistuzzo C, Braithwaite M, Snell G, Holland AE. Patient expectations and experiences of rehabilitation following lung transplantation. Clinical Transplantation 2014; 28(2):252-8.

Green S, McDonald S, Holland AE, Elkins M. Informing physiotherapy decisions with reliable evidence: how physiotherapists have contributed to Cochrane and Cochrane has informed evidence-based physiotherapy. Journal of Physiotherapy 2014; 60(1):1-4.

Cox NS, Alison JA, Holland AE. Interventions for promoting physical activity in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2013 Dec 13;12:CD009448.

Cox NS, Alison JA, Button BM, Wilson JW, Morton JM, Dowman LM, Holland AE. Validation of a multi-sensor armband in during free-living activity in adults with cystic fibrosis. Journal of Cystic Fibrosis 2014; 13(3):347-50.

Williams MT, Lewis LK, McKeough Z, Holland AE, Lee A, McNamara R, Phillips A, Wiles L, Knapman L, Wootton S, Milross M, Effing T. Reporting of exercise attendance rates for people with chronic obstructive pulmonary disease: A systematic review. Respirology 2014; 19(1):30-7.

Hill K, Holland AE. Strategies to enhance the benefits of exercise training in the respiratory patient. Clinics in Chest Medicine 2014; 35: 323-336.

Calthorpe S, Barber EA, Holland AE, Kimmel L, Webb MJ, Hodgson C, Gruen R. An intensive physiotherapy program improves mobility for trauma patients. Journal of Trauma and Acute Care Surgery 2014; 76(1):101-6.

Holland AE, Wadell K, Spruit M. How to adapt pulmonary rehabilitation to chronic respiratory disease other than COPD. European Respiratory Review 2013; 22: 577 - 86.

Holland AE, Mahal A, Hill CJ, Lee AL, Burge AT, Moore, R, Nicolson C, O’Halloran P, Cox NS, Lahham A, Ndongo R, Bell E, McDonald CF. Benefits and costs of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease - a multi-centre randomised controlled equivalence trial (protocol). BMC Pulmonary Medicine 2013; 13:57.

Osadnik CR, McDonald CF, Miller BR, Hill CJ, Tarrant B, Steward R, Chao C, Stodden N, Oliveira CC, Gagliardi N, & Holland AE. The effect of positive expiratory pressure (PEP) therapy on symptoms, quality of life and incidence of re-exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease – a multicentre, randomised controlled trial. Thorax 2014; 69(2):137-43.

Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WDC, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FME, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJA, Collins E, Garcia-Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AMWJ, Carlin B, Benzo R, Meek P, Morgan M, Rutten-van Mölken MP, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF, Wouters EFM. An Official American Thoracic Society / European Respiratory Society Statement: Key concepts and advances in pulmonary rehabilitation - An Executive Summary. American Journal of Respiratory and Critical Care Medicine 2013; 188(8): e13-64.

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