Staff profile

Dr Sofia Caria

Research Officer

Faculty of Science, Technology and Engineering

School of Molecular Sciences
Department of Biochemistry
La Trobe Institute for Molecular Science

Room 616 (Office), 602 (Lab) LIMS, Melbourne (Bundoora)

 

Brief Profile

 

  • Research officer - La Trobe University

Kvansakul lab

January 2012 - Present

Structural biology of cell death and host-pathogen interactions. Studies on viral Bcl-2 proteins and how they contribute to the development and maintenance of virus-associated tumours such as Kaposi’s sarcoma or Epstein-Barr Virus.

 

  • Postdoctoral fellow - Monash University

June 2011 - January 2012

Structural based drug design in E. coli DsbA protein.

 

  • Ph.D. student - European Synchrotron Radiation Facility and Faculdade de Farmacia, Universidade de Lisboa

November 2006 - October 2010

Structural and biochemical characterisation of the PhoR-PhoB two component regulatory system from Deinococcus radiodurans.

 

  • Graduated student - Instituto de Tecnologia Química e Biológica

March 2006 - September 2006

Biochemical characterisation of Agf proteins from Salmonella enterica serovar Typhimurium

 

  •  Undergraduate student - European Synchrotron Radiation Facility

January 2005 - January 2006

Structural and biochemical characterization of UvrA2 and UvrB proteins from Deinococcus radiodurans.

 

  • Undergraduate student - Instituto de Tecnologia Química e Biológica

April 2004 - December 2004

Biochemical characterisation of Mrk proteins from Klebsiella pneumoniae.

 

 

Recent Publications

 

Caria S, Chugh S, Nhu D, Lessene G, Kvansakul M. (2012) Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(12):1521-4. 

Caria S, de Sanctis D, Enguita FJ, McSweeney S. (2010) Crystallization and preliminary X-ray characterization of a catalytic and ATP-binding domain of a putative PhoR histidine kinase from the gamma-radioresistant bacterium Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(4):401-4.

Timmins J, Gordon E, Caria S, Leonard G, Acajjaoui S, Kuo MS, Monchois V, McSweeney S. (2009) Structural and mutational analyses of Deinococcus radiodurans UvrA2 provide insight into DNA binding and damage recognition by UvrAs.

Structure. 17(4):547-58

 

View my publications on PubMed.