Staff profile

Dr Sarah Annesley

Lecturer

Faculty of Science, Technology and Engineering

School of Life Sciences
Department of Microbiology

Melbourne (Bundoora)

 

Area of study

Microbiology

Brief profile

My research uses the simple model Dictyostelium discoideum to study neurodegenerative and mitochondrial diseases, and also to study the actin cytoskeleton and its involvement in the photosensory pathway and in mitochondrial dysfunction.

Teaching units

I teach 3rd year practical classes, lecture to 4th year (honours ) students, and organise the seminar program.

Recent publications

  1. Carilla-Latorre, S., Annesley, S.J., Muñoz-Braceras, S., Fisher, P.R. & Escalante, R. (2013). Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development. MBoC (in press).
  2. Annesley, S.J., Barth, C., Carilla-Latorre, S., Francione, L., Escalante, R. and Fisher, P.R. (2012) Investigation of mitochondrial function. In “Dictyostelium discoideum protocols II”. Methods in Molecular Biology.
  3. Sebastian Kicka, Zhouxin Shen, Sarah J. Annesley, Paul R. Fisher, Susan Lee, Steven Briggs, and Richard A. Firtel (2011).  The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol. Biol. Cell 22, 198-2211.
  4. Annesley, S.J., Bago, R., Filic, V., Weber, I., Mehta, A. & Fisher, P.R. (2011). Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS One. 6(10) e26024
  5. Ilievska, J., Bishop, N.E., Annesley, S.J. & Fisher, P.R. (2011). The roles of ESCRT proteins in normal cells and in disease. In “Current frontiers and perspectives in cell biology”. Chapter 20. pp. 453-480.
  6. Blagg, S.L., Battom, S., Annesley, S.J., Keller, T., Parkinson, K., Wu M-F., Fisher, P.R. and Thompson, C.R.L. (2011). Cell type specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.  Development 138, 1583-1593.
  7. Sugden, C., Ross, S., Annesley S.J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P.R., Barton, G. and Williams, J.G. (2011) A Dictyostelium SH2 domain adaptor protein required for correct DIF-1 signaling and pattern formation. Developmental Biology. 353(2) 290-301.
  8. Sarah J. Annesley, Ruzica Bago, Anil Mehta and Paul R. Fisher. (2011). A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development. Naunyn-Schmiedeberg's Archives of Pharmacology 384(4-5) 341-349.
  9. Lisa M.Francione, Sarah J.Annesley, Sergio Carilla-Latorre, RicardoEscalante, PaulR.Fisher. (2010). The Dictyostelium model for mitochondrial disease. Seminars in Cell & Developmental Biology 22, 120-130.
  10. Carilla-Latorre, S., Gallardo, M.E., Annesley, S.J., Calvo-Garrido, J., Grana, O., Accari, S.L., Smith, P.K., Valencia, A., Garesse, R., Fisher, P.R. & Escalante, R. (2010). MidA is a putative methyltransferase that is required for mitochondrial complex I function. Journal of Cell Science 123, 1674-1683.
  11. Annesley, S.J. (2009). Filamin: a scaffolding protein. Filamin’s role as a scaffolding protein in a photosensory signalling complex in Dictyostelium discoideum. LAP Publishing, Koln, Germany.
  12. Annesley, S.J. & Fisher, P.R. (2009) Scaffolding proteins that regulate the actin cytoskeleton in cell movement. In “Cell Movement: New Research Trends.” Eds. T.Abreu and G. Silva. Nova Science Publishers. Hauppauge NY, USA. Chapter 1. pp. 1-50. ISBN: 978-1-60692-570-6.
  13. Annesley, S.J. & Fisher, P.R. (2009). Dictyostelium slug phototaxis. In “Chemotaxis”. Ed. T. Jin and D. Hereld. Methods in Molecular Biology 571, 67-76.
  14. Annesley, S.J. & Fisher, P.R. (2009). Dictyostelium discoideum- a model for many reasons. Molecular and Cellular Biochemistry 329, 73-91.
  15. Bokko, P.B., Francione, L., Ahmed, A.U., Bandala-Sanchez, E., Annesley, S.J., Huang, X., Khurana, T., Kimmel, A.R. & Fisher, P.R. (2007). Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Molecular Biology of the Cell. 18, 1874-1886.
  16. Annesley, S.J., Bandala-Sanchez, E., Ahmed, A.U. & Fisher, P.R. (2007). Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum. BMC Cell Biol. 8, 48.
  17. Fisher, P.R. & Annesley, S.J. (2006). Slug phototaxis, thermotaxis and spontaneous turning behaviour. In "Dictyostelium discoideum Protocols." Methods in Molecular Biology. 346, 137-170. Ed. L Eichinger & F. Rivero. Humana Press.
  18. Bandala-Sanchez, E., Annesley, S.J. & Fisher, P.R. (2006). A phototaxis signalling complex in Dictyostelium discoideum. Eur. J. Cell Biol. 85, 1099-1106. (1st two authors contributed equally to this work).