Staff profile

Professor Nick J Hoogenraad

Head of School of Molecular Sciences, Executive Director, LIMS

Faculty of Science, Technology and Engineering

School of Molecular Sciences
Department of Biochemistry
La Trobe Institute for Molecular Science

Physical Science 4 Room 363/365 (L), Melbourne (Bundoora)

 

Qualifications

BAgrSc UMELB., PhD UMELB.

Membership of professional Associations

Australian Society for Biochemistry and Molecular Biology

Area of study

Biochemistry and Molecular Biology

Brief Profile

Nick Hoogenraad was trained as an agricultural scientist in the mid 1960s after which he completed a PhD in Biochemistry in 1969. He commenced his life long interests in medical research when he joined the Pediatric department at Stanford in 1970.

Over his long career in science Nick Hoogenraad's work has focussed on mitochondrial biogenesis and on the role of molecular chaperones in protein targeting and folding in mammalian cells. He has also been active in translational research as part of the Cooperative Research Centres for Diagnostic Technologies, the CRC for Diagnostics and recently led a team which was awarded $30.7 million for the CRC for Biomarker Translation (2007). This research is directed to producing Diagnostic and Therapeutic antibodies for the treatment of cancer and autoimmune disease. He has won many major awards for his research  (including the Lemberg Medal of the Society for Biochemistry and Molecular Biology (2004); Leach Protein Chemistry Medal (1997); AMRAD/Pharmacia Biotechnology Medal (1994)) and has served on numerous committees including President of ASBMB (1996-1999); ARC Biological Sciences Panel(1991-1994); NHMRC Biochemistry Panel(2004-2007); ANZ Trustees( 2000-2007).

In his spare time Nick and his family runs a vineyard in the Diamond Valley which produces award winning Pinot Noir.

Consulting

Member of the Board of Transbio Ltd

Recent Publications

Poulsen, J.B., Andersen, K.R., Kjaer, K.H., Durand, F., Faou, P., Vestergaars, A.L., Talbo, G.H., Hoogenraad, N., Brodersen, D.E., Justesen, J. and Martenesen, P.M. (2011). Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover. Nucleic Acids Research 39, 3754-3770.

Cvrijevic, A.N., Akhavan, D., Wu, M., Martinello, P., Furnari, F.B., Johnston, A.J., Guo, D., pike, L., Cabanee, W.K., Scott, A.M., Mischel, P.S., Hoogenraad, N.J. and Johns, T.G. (2011). Activation of Src induces mitochondrial loaclisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. Journal of Cell Science 124, 2938-2950.

Rath, E., Berger, E., Messlik, A., Nunes, T., Liu, B., Kim, S.C., Hoogenraad, N., Sans, M., Sartor, R.B. and Haller, D. (2011). Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation. Gut, online October 13, 2011.

Faou, P. and Hoogenraad, N.J. (2012). Tom 34: A cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import. Biochemica et Biophysica Acta, Molecular Cell Biology 1823, 348-357.