Staff profile

Dr Jasim Al-Rawi

Senior Lecturer

Faculty of Science, Technology and Engineering

School of Pharmacy and Applied Science
Department of Pharmacy

Applied Science 1, Room 2.14B, Bendigo

 

Qualifications

BSc. Baghdad, Ph.D. Surrey, MRACI C CHEM

Membership of professional associations

Member of Royal Australian Chemical Institute (MRACI C CHEM)

Area of study

Medicinal Chemistry
Pharmacy

Brief profile

   I did my PhD with Professor John Elvidge Surrey University UK on heterocyclic synthesis I also spend two years post-doctoral fellowship at Surrey University working with Professor John Elvidge and Professor John Jones on the development of tritium NMR and some of its applications. I did move back to Iraq (1976 -1990) and become involved in a range of different areas of research such as heterocyclic synthesis and the development of some NMR techniques. Since 2001 I joined Latrobe University. I am positioned in the School of Molecular Sciences, Department of Pharmacy working on the synthesis and the  assay of new biologically active heterocyclic molecules please see below 

  • Synthesize a range of substituted 2-amino-8-substituted -1, 3 oxazine compounds using novel methods of organic synthesis. Test the synthesized compounds for antiplatelet and DNA-Dependent Protein Kinase inhibitory activity. Correlate activity with chemical substitution to find those compounds and structures that give the highest activity.
  • Synthesis, Antiplatelet and DNA-Dependent Protein Kinase inhibitory activity of 2-(amino)-8-substiuted-4H,5H-chromeno[3,4-e][1,3]oxazine-4,5-dione
  • Synthesis of Novel 7-Substituted-Synthesis of Novel 7-Substituted-2-thioxo Quinazolin-4-ones from 4-Substituted-2-Aminobenzoic Acids and PPh3(SCN)2

 

 

Research interests

Organic, Pharmaceutical and Medicinal Chemistry

- Synthesis, and DNA-dependant protein kinase IC50, docking, anti-microbial and anti-platelet activity

Teaching units

CHE1C1B Chemistry 1B

CHE2MCA Medicinal Chemistry A

CHE2CAN Chemical Analysis (Spectroscopy part)

Recent publications

 

  •   Jacob Heppell and Jasim Al-Rawi, Functionalisation of Quinazolin-4-ones Part 1:  Synthesis of Novel7-Substituted-2-thioxo Quinazolin-4-ones from 4-Substituted-2- Aminobenzoic Acids and PPh3(SCN)2 . Journal of Heterocyclic Chemistry, Accepted    2012 ·       
  • Jason D. McKerrow a; Jasim M. A. Al-Rawi and Peter Brooks. Synthesis of some N-Aryl        α-Amino Acids Using Diaryliodonium Salts. Asian j. Chem., 24(2012) 1227-1236 ·        Saleh Ihmaid , Jasim Al-Rawi , Christopher Bradley , Michael J. Angove , Murray N. Robertson , Rachel L. Clark Synthesis, structural elucidation, DNA-PK inhibition, homology modeling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines. Bioorg. Med. Chem. 19 (2011) 3983–3994.
  • Saleh Ihmaid, Jasim Al-Rawi and Christopher Bradley, Synthesis, structural elucidation and DNA-dependant protein kinase and antiplatelet studies of 2-amino-[5, 6, 7, 8- mono and 7, 8-di-substituted]-1,3-benzoxazines. European Journal of Medicinal Chemistry, 45 (2010) 934.
  •  Jason D. McKerrow a; Jasim M. A. Al-Rawi and Peter Brooks. Use of Diphenyliodonium bromide in the synthesis of some N-phenyl α-amino acids, Synthetic Communications, 40: 1161–1179, 2010.
  •   Pritchard, Kaylene M.; Al-Rawi, Jasim. Reaction of Ph3P(SCN)2 with Further Orthohydroxy Carboxylic Acid Systems, Including Substituted b -Keto Acids: Synthesis of Novel 2-Thio-1,3-oxazines and Their Subsequent Transformation with Amines.    Synthetic Communications 2008), 38(23), 4076-4096.
  •   Kaylene M. Pritchard, Jasim Al-Rawi, Christopher Bradley. Synthesis, Identification and antiplatelet Evaluation of 2-morphonyl-benzoazine European Journal of Medicinal Chemistry 42 (2007) 1200-1210.
  • Kaylene Pritchard, Jasim Al-Rawi, and Andrew Hughes, A generalised method for the production of 1,3-benzoxazine, 1,3-benzothiazine and quinazoline derivatives from 2-(hydroxy, thio, or amino) aromatic acids using the triphenylphosphine thiocyanogen reagent,  Synthetic Communication 35: 1601–1611, 2005.
  • Sheat, Mohammed A.; Al-Rawi, Jasim M. A., Synthesis of 2-substituted-3-oxo-3- [(aryloxycarbonyl) amino] propanoic acid, ethyl 3-{[(1E)-ethoxy (aryloxy) methylene] amino}-2-substituted-3-oxopropanoate, (1Z, 2Z) [chloro (aryloxy) methylene] hydrazines and Structurally Related Compounds from the Reaction of Alkyl or Aryl malonyl Chlorides with Aryl Cyanates. Asian J. Chemistry 17(2),798 – 810, 2005.
  • Mohammed A. Sheat and Jasim M. A. Al-Rawi. Heterocyclic Synthesis from the Reaction of Aryl cyanate with Malonyl chloride, and Bromomalonyl chloride, Asian J. Chemistry 17(3),1889 – 1901, 2005.

 

Resume

Download Resume

Older publications

 

 

Research projects

Synthesis, and DNA-dependant protein kinase IC50, docking, anti-microbial and anti-platelet activity studies of substituted benzo, naphtho, chromeno (1,3) oxazines, and quinazolin-4-ones