Staff profile
Professor Graham D Lamb
NHMRC Senior Principal Fellow, Professor
Faculty of Science, Technology and Engineering
School of Life SciencesDepartment of Zoology
Biological Sciences Building 1, Room 312, Melbourne (Bundoora)
- T: +61 3 9479 2249
- F: +61 3 9479 1551
- E: g.lamb@latrobe.edu.au
- W: http://www.latrobe.edu.au/zoology
Qualifications
MSc, PhD, UMELB
Membership of professional associations
Journal of Physiology, Journal of Muscle Research & Cell Motility, American Journal of Physiology Cell Physiology, Member of NH&MRC Research Fellowship Committee
Area of study
Biochemistry and Molecular Biology
Physiology
Zoology
Research interests
Muscle cell physiology
- Excitation-contraction coupling in health, exercise and disease
Teaching units
- Excitable Tissues
- Neuromuscular Disorders
Recent publications
- Dutka TL & Lamb GD (2004). Effect of carnosine on excitation-contraction coupling in mechanically-skinned fibres of rat skeletal muscle. Journal of Muscle Research & Cell Motility 25, 203-13.
- Nielsen OB, Ortenblad N, Lamb GD & Stephenson DG (2004). Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+-K+ pump activity. Journal of Physiology 557, 133-46.
- Murphy RM, Stephenson DG & Lamb GD (2004). Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle. American Journal of Physiology Cell Physiology 287, C1589-95.
- Pedersen TH, Nielsen OB, Lamb GD & Stephenson DG (2004). Intracellular acidosis enhances the excitability of working muscle. Science 305, 1144-1147.
- Dutka TL & Lamb GD (2004). Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat. Journal of Physiology 560, 451-68.
- Laver DR, O'Neill ER & Lamb GD (2004). Luminal Ca2+-regulated Mg2+inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters. Journal of General Physiology 124, 741-58.
- Dulhunty AF, Cengia L, Young J, Pace SM, Harvey PJ, Lamb GD, Chan YN, Wimmer N, Toth I & Casarotto MG (2005). Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 144, 743-54.
- Lamb GD (2005). Rippling muscle disease may be caused by "silent action" potentials in the tubular system of skeletal muscle fibers. Muscle & Nerve 31, 652-8.
- Verburg E, Murphy RM, Stephenson DG & Lamb GD (2005). Disruption of excitation-contraction coupling and titin by endogenous Ca2+-activated proteases in toad muscle fibres. Journal of Physiology 564, 775-90.
- Dutka TL, Cole L & Lamb GD (2005). Calcium phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca2+release in mammalian skeletal muscle. American Journal of Physiology Cell Physiology 289, C1502-12.
- Murphy RM, Snow RJ & Lamb GD (2006). mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. American Journal of Physiology Cell Physiology 290, C116-22.
- Verburg E, Dutka TL & Lamb GD (2006). Long-lasting muscle fatigue: partial disruption of excitation-contraction coupling by the elevated cytosolic [Ca2+] during contractions. American Journal of Physiology Cell Physiology 290, C1199-1208.
- Yang Z, Ikemoto N, Lamb GD & Steele DS (2006). The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+release in permeabilized cardiomyocytes. Cardiovascular Research 70, 475-485.
- Trinh HH & Lamb GD (2006). Matching of sarcoplasmic reticulum and contractile properties in rat fast- and slow-twitch muscle fibres. Clinical and Experimental Pharmacology and Physiology 33, 591-600.
- Murphy RM, Verburg E & Lamb GD (2006). Ca2+activation of diffusible and bound pools of mu-calpain in rat skeletal muscle. Journal of Physiology 576, 595-612.
- Dutka TL & Lamb GD (2007a). Transverse tubular system depolarization reduces tetanic force in rat skeletal muscle fibers by impairing action potential repriming. American Journal of Physiology Cell Physiology 292(6):C2112-21.
- Dutka TL & Lamb GD (2007b). Na+-K+ pumps in the transverse tubular system of skeletal muscle fibers preferentially use ATP from glycolysis. American Journal of Physiology Cell Physiology 293(3):C967-77.
- Murphy RM, Goodman CA, McKenna MJ, Bennie J, Leikis M & Lamb GD (2007). Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise. Journal of Applied Physiology 103(3):926-31.
- Laver DR, Honen BN, Lamb GD & Ikemoto N. (2008). A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca(2+) via cytoplasmic Ca(2+) sites. European Biophysical Journal 37, 455-67
- Dutka TL, Murphy RM, Stephenson DG & Lamb GD. (2008). Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue. Journal of Physiology 586: 875–887.
- Allen DG, Lamb GD & Westerblad H. (2008a). Skeletal muscle fatigue; cellular mechanisms. Physiological Reviews 88, 287-332.
- Allen DG, Lamb GD & Westerblad H. (2008b). Impaired calcium release during fatigue. Journal of Applied Physiology 104, 296-305.
- Murphy RM, Dutka TL & Lamb GD. (2008). Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres. Journal of Physiology 586, 2203-2216.
- Mollica JP, Oakhill JS, Lamb GD, Murphy RM. (2009). Are genuine changes in protein expression being overlooked? Reassessing Western blotting. Anal Biochem. 386(2):270-5.
- Murphy RM, Lamb GD. (2009). Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretch. J Biol Chem. 284: 7811-9.
- Murphy RM, Mollica JP, Lamb GD. (2009). Plasma membrane removal in rat skeletal muscle fibers reveals caveolin-3 hot-spots at the necks of transverse tubules. Exp Cell Res. 315: 1015-28.
- Murphy RM, Larkins NT, Mollica JP, Beard NA, Lamb GD. (2009). Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. J Physiol. 587: 443-60.
- Dutka TL, Mollica JP, Lamb GD. (2011). Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat. Journal of Applied Physiology (in press).
- Dutka TL, Mollica JP, Posterino GS, Lamb GD. (2011). Modulation of contractile apparatus Ca2+-sensivitivity and disruption of excitation-contraction coupling by S-nitrosoglutathione in rat muscle fibres. Journal of Physiology (in press).
- Lamb GD, Westerblad H. (2011). Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle. Journal of Physiology (in press).
- Murphy RM, Mollica JP, Beard NA, Knollmann BC, Lamb GD. (2011). Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2 knockout mice. American Journal of Physiology Heart & Circulation 300: H595-604.


