Staff profile

Dr Clare Slaney

Research Fellow

Faculty of Science, Technology and Engineering

School of Molecular Sciences
Department of Biochemistry
La Trobe Institute for Molecular Science

Room 524, Melbourne (Bundoora)

 

Qualifications

BSc, MSc (Hons), PhD

Membership of professional associations

Australasian Society of Immunology, Metastasis Research Society, The International Society for Interferon and Cytokine Research

Area of study

Biomedical Science

Brief profile

  • 2012-2015 National Breast Cancer Foundation and Cure Cancer Australia Postdoctoral Training Fellowship
  • 2012 Seymour and Vivian Milstein Young Investigator Award for notable contributions to basic and clinical research (by the International Society for Interferon and Cytokine Research).
  • 2012 CASS Foundation Travel Grant, Australia
  • 2009 Victoria University of Wellington Doctoral Completion Awards, New Zealand
  • 2006-2009 Lottery Health Research New Zealand PhD scholarship, New Zealand
  • 2008 Wellington Medical Research Foundation Research travel grant, New Zealand

Recent publications

Slaney, CY, Toker, A, Fraser, JD, Harper JL, Bäckström, BT. (In press) A modified superantigen targets blood monocytes to switch on antigen-specific suppression of autoimmunity. Autoimmunity   (PMID:23374140)

 

Slaney, CY, Moller A, Hertzog PJ, Parker BS (2013) The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone. Oncoimmunology 2(1): e223391-3

 

*Bidwell, BN, *Slaney, CY, Withana, NP, Andrews, D, Mangan, N, Samarajiwa, SA, Cao, Y, Anderson, .L, Hertzog, P and Parker, BS (2012) Silencing of Irf7 expression in breast cancer cells promotes bone metastasis through immune escape mechanisms. Nature Medicine (18) 1224-1231. *Co-First Authors. 

This paper was highlighted in Nature as: Research highlights: Pathway from breast to bone. Nature (487): 408. 

 

Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M and Parker B (2012) Selective inhibition of cathepsin B reduces spontaneous bone metastasis in the syngeneic 4T1.2 mouse model. Cancer Research 72 (5): 1199-1209.

 

 *Slaney CY, Toker A, Flamme AL, Bäckström BT, & Harper JL (2011) Naive blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity. Immunology and Cell Biology (89)7-13.  

*This paper received a commentary paper as Saha P & Geissmann F (2011) News and commentary: Toward a functional characterization of blood monocytes. Immunology and Cell Biolology (89):2-4.

 

Toker A, Slaney CY, Harper JL and Bäckström BT. (2011) Glatiramer acetate specifically binds naïve CD11b+Ly6G- monocytes and can engage multiple mechanisms to suppress self-reactive T cell activation. Scandinavian Journal of Immunology 74(3): 235-243.

 

Papers published under my maiden name: Yan Bai (Name changed in Dec/09)

Dickgreber N, Stoitzner P, Bai Y, Price K, Farrand K, Manning K, Angel C, Dunbar P, Ronchese F, Fraser J, Bäckström BT, and Hermans I. (2009) Targeting antigen to MHC class II molecules promotes cross-presentation and enhances immunotherapy. Journal of Immunology 182(3): 1260-1269.

 

Bai Y, Robinson E, Chai R, Ross JM, Reddy S. (2006) Immunohistochemical study of monocyte chemoattractant protein-1 in the pancreas of NOD mice following cyclophosphamide administration and during spontaneous diabetes. Journal of Molecular Histology 37 (3-4): 101-113.

 

Reddy S, Bai Y, Robinson E, Ross JM. (2006) Immunolocalization of monocyte chemoattractant protein-1 (MCP-1) in islets of NOD mice during cyclophosphamide administration. Annals of the New York Academy of Sciences 1079: 103-108.

 

Reddy S, Pathipati P, Bai Y, Robinson E, and Ross JM. (2005) Histopathological changes in insulin, glucagon and somatostatin cells in the islets of NOD mice during cyclophosphamide-accelerated diabetes: a combined immunohistochemical and histochemical study. Journal of Molecular Histology 36(4): 289-300.

Research projects

Immune regulation of breast cancer metastasis