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Hyperkeratoses
of non-mechanical origin
Genodermatoses
o Autosomal > Sex-linked
o
Autosomal dominant > autosomal recessive
o
Complete/incomplete
• Palmoplantar keratodermas
o
Diffuse palmoplantar keratoderma (Unna-Thost syndrome)
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Diffuse thickening of palms and soles
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Developed in the infant by 18 months of age
• Punctate keratodermas
o
Punctate, well defined, round to oval keratotic lesions
o
Can appear like multiple corns
• Mutilating keratoderma (Vonwinkel syndrome)
o
Palmar and plantar lesions are honeycombed with small depressions
o
Constrictive bands can lead to auto-amputation
• Striate keratoderma
Acquired Keratoses
o Hyperkeratoses which develop for reasons other than genetic predisposition
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Systemic causes
o
Hyperthyroidism
o
Carcinoma
o
Psoriasis
o
STD’s
•
External causes
o
Occupational
o
Dermatomycoses
o
Wart infections
o
Solar keratoses
•
Internal
o
Gold
o
Quinacrine
o
Arsenic
Malignant tumour of the epidermis
- Basal cell carcinoma
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Squamous cell carcinoma
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