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Department of Podiatry

Diabetes Mellitus - Lecture 3

Lecturer: Craig Payne
 

This lecture will cover:

Psychosocial aspects of diabetes

Management of type 1 diabetes

Management of type 2 diabetes

Special groups and situations in those with diabetes

 

Psychosocial impacts of diabetes

Issues that need to be considered:
- Psychosocial sequelae of diabetes (what psychological and social consequences are there with when diabetes is firs diagosed?; when it is well established?)
- Psychopathology in diabetes (there is a higher prevalance of psychological and psychiatric problems in those with diabetes)
- Stress and hassles (what stresses and inconviences are there associated with having diabetes)
- Family dysfunction (what does it do to dynamics within the family?)

What are the impacts of diabetes (egs)
- Need to depend on others
- public confusion between type 1 & 2 ("everyone" does not need insulin injections)
- public misconceptions re diet
- deciding who to tell (family, coworkers, employer)
- feelings of loss of control and embarrassment associated with hypos
- having to inject insulin
- drivers license (does the risk of a hypo put them at risk on the road?)
- expenses (it costs!!!)
- discrimination (life insurance; work place)
- exclusion from some activities (scuba diving; driving passenger vehicles; military)
- any others?

Psychopathology
- eating disorders are common
- self destructive behaviour

- depression
- cognitive functioning

Stress and hassles
- Stress affects glycaemic control:
- increased secretion of counterregulatory hormones
- disruption of self care routines

Effects on family
- Strong correlation between poor glycaemic control, psychological disturbance and poor family functioning
- Impacts both on the person with diabetes and the family members without diabetes
occasionally it may increase family cohesion and solidarity

Online resources

Hypoglycemia and Employment/Licensure - full text article from the American Diabetes Association

 
Management of Type One Diabetes

 

Cornerstones of the management of type 1 diabetes:
- Use of exogenous insulin for glycaemic control
- Education in self management
- Self-monitoring of blood glucose (SMBG)
- Specific measures to manage complications

Aims of management of Type 1 & 2:
- Reduce random blood glucose levels 4 - 8 mmol/L
- HbA1c < 7% (supported by evidence from DCCT & UKPDS)
- Cholesterol < 5.5mmol/L (aggressive management of dyslipidaemia reduces risk of macrovascular disease)
- Blood pressure 140/90 or less (strong correlation between hypertension and adverse outcomes in diabetes)
- BMI <25kg/m2
- Cigarette consumption = 0 (higher risk of macrovascular disease and mortality in those that smoke)
- Alcohol consumption < 2 standard drinks a day
- Exercise at least 20 minutes, 4+ days/week

Insulin:
- Discovered in 1921 - type 1 diabetes was no longer a fatal disease
- Indications for insulin - type 1 diabetes; acute complications; pregnancy; longstanding type 2 that has not responded to oral agents.
- Manufactured from recombinant DNA technology
- Half life of 7 mins - clearly mainly by liver and kidneys

Delivery of insulin:
- injection subcutaneously in anterior abdomen, upper arms, outer thighs or buttocks
rate of absorption depends on depth, site skin temperature, local massage, exercise, amount of lipodystrophy
- administered with use of disposable syringes or pen injectors
- battery powered pump systems can be used to supply subcutaneous or IV infusions of insulin - controlled by patient. Earlier models prone to failure - rapid onset of ketoacidosis

Insulin regimens:
- Various regimens are used - depends on many factors (eg patient lifestyle, self-management ability, desired level of control).

- Most regimens involve two to four injections of short or long acting insulin.

Side effects of use of insulin -
- hypoglycaemia, weight gain, lipodystrophy at injection sites

Diabetes Control and Complications Trial (DCCT)
- 1441 type 1 subjects, 29 centres in USA and Canada over 7 years
- landmark study that showed, beyond doubt, that good glycaemic control plays an important role in the prevention of complications
- found intensive/strict control of glycaemic level reduced the risk for retinopathy by 76%; nephropathy 50%; and neuropathy 60% compared to those with conventional control; also delayed onset of complication
- weight gain was more common and more hypoglycaemic episodes occurred in the intensely controlled group - but no increase in deaths, or cardiac or neurological

Online resources:

ePodiatry's links to online articles on diabetes management

Implications of the Diabetes Control and Complications Trial - full text article from the American Diabetes Association

Insulin Administration - full text article from the American Diabetes Association

Type 1 Diabetes Mellitus and the Use of Flexible Insulin Regimens - full text article from the American Family Physician

 

Management of type 2 diabetes

 

Cornerstones of type 2 dianates management
- Control symptoms
- Education
- Obtain reasonable glycaemic control (exercise, diet, drugs) - some go to insulin
- Reduce risk factors for macrovascular and macrovascular disease
- Detect (screening) and treat complications early

Oral hypoglycaemic agents
Sulfonylureas

- stimulates insulin release from the beta cell - some restore the sensitivity of the beta cell to glucose (will not be effective if pancreas can not synthesise insulin)
- used primarily for non-obese type 2 patients who do not respond to diet modification alone (not used often in obese due to weight gain associated with use - increase in insulin resistance)
- Eg Tolbutamide (Diabinese™); Glibebclamide (Daonil™, Euglucon™, Glimel™); Gliclazide (Diamicron™); Glipizide (Minidiab™).
- Adverse effects - hypoglycaemia, weight gain, GI disturbances, rashes abnormal liver function tests.

Biguanides:
- Appear to decrease liver gluconeogenesis and increases peripheral insulin sensitivity - may also inhibit glucose absorption by GI tract
- have more side effects than sulfonylureas
- Eg Metformin (Diabex™, Diaformin™, Glucaphage™)
- Does not cause hypoglycaemia or contribute to weight gain (use in obese patients)
- may be used with a sulfonylurea (effects are synergistic)
- Adverse side effects - 50% develop GI problems

Thiazolidinediones (troglitazone, rosiglitazone (Avandia™), pioglitazone (Actos™) - enhance endogenous insulin action in liver and peripheral tissues (improves insulin sensitivity in those that are insulin resistant) - also decrease triglyceride levels, increase HDL levels and lowers blood pressure.
Repaglinide - stimulates release of insulin from pancreas
Dexfenfluramine - may have hypoglycaemic effect
Alpha glucosidase inhibitors (Acarbose) - delays carbohydrate absorption in the GI tract - lowers postprandial blood glucose à modest improvement in glycaemic control; can be used with a sulfonylurea; side effects - flatulence, diarrhoea, bloated abdomen


UK Prospective Diabetes Study (UKPDS)
- 10 year study in those with type 2 diabetes
- showed that intensive control in type 2 by sulphonylureas or insulin substantially reduced risk of microvascular complications, but not macrovascular
- retinopathy, nephropathy and possibly neuropathy can benefit form lowering blood glucose levels in type 2 diabetes
- showed that risks can be significantly reduced when HbA1c levels are <8.0%
- also showed that lowering blood pressure reduced the incidence of cardiovascular complications

Dietary management
- Nutritional management is fundamental part of the management in all those with diabetes mellitus.
- Adherence to advice regarding nutritional therapy is also a fundamental challenge for all those involved in the management of those with diabetes mellitus.

- Dietary/nutritional management is complex - importance of involvement of dietitian.

Prevention of diabetes
Type 2:
- lifestyle interventions, especially exercise can reduce incidence of type two diabetes mellitus

Type 1:
- now have predictive markers that now gives some prediction of the development of type 1 diabetes - potential for intervention studies

Online resources:

ePodiatry's links to online articles on diabetes management

Oral Agents in the Management of Type 2 Diabetes Mellitus - full text from the American Family Physician

New Dietary Guidelines and Exercise Recommendations - online article from Diabetes In Control

Implications of the United Kingdom Prospective Diabetes Study - full text article from the American Diabetes Association

The Prevention or Delay of Type 2 Diabetes - full text article from the American Diabetes Association

Prevention of Type 1 Diabetes Mellitus - full text article from the American Diabetes Association

 

Education and delivery of diabetes care

Diabetes is a chronic non-curable disease - management by self is important

A large element of diabetes care is self management - knowledge is needed for this to be done.

Guiding Principles of Education:
- Must be tailored to the patients needs
- does not necessarily translate into action
- ongoing process that needs reinforcement
- should take form of a partnership
- needs to address patients agenda
- Diabetes Nurse Educators receive special training

- Didactic lectures are generally not as effective at modifying behaviour
- individualised or group teaching is generally considered as being more productive
- interactive computer programs may be effective
- overload of information is counterproductive
- prior to starting, initially assess knowledge, skills and attitudes

Ethnicity, social background, financial circumstances, lifestyle, health beliefs and educational background will influence educational message


- information needs to be delivered in small digestible chunks
- move from the simple to the complex
- scare tactics only have short term impact (unless results are imminent)
- adults like to be involved in their education

Learning is enhanced when the patient:
- Feels a need to know what is being taught
- can relate it to what they already know
- feel the material is personally relevant
- have confidence that they can do what they have been taught
- is actively, rather than passively involved
- has feedback on what they can do

Health Belief Model (one model can can be used to explain behaviour)
A health protective behaviour is carried out based on the psychological weighing up of the following:
- perceived susceptibility/vulnerability to the condition
- perceived severity of the condition
- perceived benefits of the health protective behaviour
- perceived barriers to carrying out the health protective behaviour

Monitoring of glucose levels
Assessment and monitoring of glycaemic status is a cornerstone of diabetes care and self-management.

Urine testing:
- use of strips to measure pre-prandial glucose levels in urine
- has major limitations (due to raised renal threshold for glucose - mostly in type 1)
- can be used by some with type 2 who have stable glucose levels and are controlled by diet
- largely been replaced by self monitoring of blood glucose, but has a role for detection of ketone levels, especially during pregnancy or acute illness


Blood testing:
Capillary blood glucose levels/self monitoring of blood glucose (SMBG):
- should be performed regularly at home so achievement of specific glycaemic goals can be achieved and maintained
- blood glucose reagent strips are read visually or with a glucose meter
- information is available immediately - well informed decisions and helps motivation
- provide information for day to day management, but is not an indicator of longer term glycaemic levels

Glycated haemoglobin:
- measure of control over 120 days (average life span of red blood cell)
- HbA1c - stable minor haemoglobin component that form slowly from the non-enzymatic combination of haemoglobin and glucose. The rate of formation is directly proportional to the glucose concentration
- blood is assayed by a number of different methods - some variability between laboratories
has become the 'standard' for assessing glycaemic control - shown to be predictive of many chronic complications

Organisation of Diabetes Care
Need access to a multidisciplinary team

Best delivery via concept of ‘Diabetes Centres’:
- diagnosis and assessment of new patients
- long term follow up
- continuing education of patients and staff
- screening for chronic complications
- specialist foot care
- specialist care for special groups (eg pregnancy)
- provision of telephone advice

Diabetes Centre staff
- Diabetologist
- specialist nurse
- dietician
- podiatrist
Access to:
- nephrologist
- obstetrician
- vascular surgeon
- ophthalmic surgeon
- orthopaedic surgeon

- cardiologist
- psychologist

A comprehensive annual review is considered the key of structured diabetes management:
1) Discussion
- physical and psychological health
- review of results of self monitoring
- enquiry into episodes of hypos and hypers
- knowledge of diabetes and self management
- smoking and alcohol use
- discussion of other diabetes related problems

2) Physical examination
- BMI
- BP
- Visual acuity
- Detailed fundus examination
- Inspection of feet and footwear
- Injection sites

3) Investigations
- Urinalysis (for proteins)
- HbA1c
- Serum creatinine and electrolyte concentrations
- Serum lipids

4) Management
- Glycaemic control review
- Assessment of co-morbidity
- Review of all medications
- Attention to modifiable cardiovascular risk factors
- Management of long term complications
- Management plan for next 12 months
- Arrange review date

Online resources:

Glycaemic control in diabetes - full text article from the British Medical Journal

Effective diabetes care: a need for realistic targets - from the British Medical Journal

 

 

Special Groups and Situations

Exercise and diabetes
Exercise for those with diabetes was originally recommended by Aristotles and is potentially an important component of the management of diabetes, especially type 2

The development of type 2 diabetes in those at risk for it is inversely proportional to the amount of physical activity

The greater a sedentary lifestyle (as measured by the number of hours watching television) is directly related to the risk for developing type 2 diabetes

Benefits of exercise for those with diabetes
- reduced hyperinsulinaemia
- increase in insulin sensitivity (improved receptor site binding)
- reduced body fat
- decreased blood pressure
- improvement in dyslipidaemia
- may get increased glucose uptake for a given level of insulin
- those that exercise may be motivated to pay closer attention to diet and blood glucose monitoring
- all other general benefits of exercise will be of benefit to those with diabetes

Risks of exercise
- hypoglycaemia (can occur up to 6 to 24 hours after exercise) - 'post-exercise delayed onset hypoglycaemia'
- neuropathy - increased risk for foot complications with weightbearing exercise
- ischaemic disease - foot at risk during weightbearing activities
- prevalence of stress fractures appears to be higher in those with diabetes
- those with proliferative retinopathy need to avoid activities that may raise blood pressure (eg weight lifting)

Strategies for exercise
- those with diabetes need to have a good understanding what effect that exercise has on their blood glucose levels
- may not be save to exercise with high or low blood glucose levels
- diabetes identification should be carried when exercising
- supplemental carbohydrate should be taken during exercise
- delay exercise if blood glucose is high
- take insulin > 1 hour before exercise
- insulin dose should be decreased prior to exercise
- blood glucose levels should be monitored before, during and after exercise
- avoid dehydration
- exercise with someone else
- increase food intake <24 hour after exercise

Surgery
Catabolic stress of surgery (in those with or without diabetes) increased secretion of cortisol, catecholamines, glucagon and growth hormone increased glycogenolysis, gluconeogenesis, lipolysis, proteolysis and insulin resistance need more insulin to counteract.

In those with diabetes this will result in diabetic ketoacidosis need for careful perioperative planning and management.

Intercurrent Illness
- When ill - this affects metabolic control
- Blood glucose level controls during acute illness is crucial
- Type 2 DM’s may need insulin

Strategies:
- education to overcome fear
- test glucose every 2-3 hours
- extra doses of insulin as required
- if vomiting, test for ketones
- try to maintain CHO intake
- drink plenty of fluids

Pregnant (maternal and foetal risks)
Maternal
- metabolic control decreases later in pregnancy
- retinopathy and nephropathy worsen
- risk of toxaemia is doubled
- subclinical CHD is unmasked
- increased risk of UTI
- increased rates of caesarian section

Foetal
- increased risks of congenital malformation, stillbirth, perinatal mortality
- increased life time risk of diabetes

Children
Issues:
- insulin at preschool & school

- family stress

Adolescence
Issues:
-peer pressure
- sick days
- diet
- psychological problems (eg disordered eating)
- drug use
- manipulation

Online resources:

Full text articles from the American Diabetes Association:

Physical Activity/Exercise and Diabetes Mellitus

Preconception Care of Women With Diabetes

Care of Children With Diabetes in the School and Day Care Setting


 
Links to:
Lecture 1; Lecture 2; Lecture 4; Lecture 5; Lecture 6
 


Content Approved by: Head of Podiatry
Page maintained by: Podiatry Webmaster
Last Updated: August 20th, 2002