The central nervous system control of metabolically evoked brown adipose tissue thermogenesis
Brown adipose tissue (BAT) thermogenesis is tissue specialized for using circulating free fatty acids in the body, and wasting that stored energy as heat. Historically, BAT thermogenesis has been investigated for its role in body temperature regulation and fever response. More recently, however, BAT has been implicated in the regulation of body weight.
Our research is focused on identifying specific neural pathways within the CNS that regulate BAT thermogenesis. Crucially, we are interested in understanding the neurotransmitter systems that control BAT activity in the hope of identifying potential drug targets for exogenous regulation of BAT.