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Group leaders

Members

PhD students

Major research questions being addressed by this group

The influence of certain neuropeptides, hormones and nerves on normal bone metabolism

The influence of certain neuropeptides, hormones and nerves on fracture repair

How is the breakdown of joint connective tissues regulated in osteoarthritis?

What is the molecular and cellular basis of patellar tendon pathology?

Current research grants

Ilic M. Faculty of Health Sciences Research Grant 2006: Transcription factors and cartilage loss in arthritis $10,000.

Handley CJ. Faculty of Health Sciences Research Grant 2006: Changes in the organization and metabolism of tendons in overuse tendon disease $15,000.

Handley CJ. La Trobe Central Large Grant Scheme 2007: Control of matrix breakdown in joint connective tissues $25,000.

Grills B. Faculty of Health Sciences Research Grants 2006: Effects of galanin on osteoporosis, $9965.

Grills B. Dept of Human Physiology and Anatomy in-house Grant 2007: Adrenergic effects on the contractility of early bone fracture callus, $9000.

McDonald A. Faculty of Health Sciences Research Starter Grant 2007: Effects of relaxin on osteoporosis, $5000.

Key publications

Yao M, Schuijers JA, Dooley PC, Grills BL. Nerve growth factor and norepinephrine concentrations in weight-bearing and non-weight-bearing bones of euthyroid and hyperthyroid rats. Journal of Musculoskeletal and Neuronal Interactions 2002;2:237-334.

McDonald AC, Schuijers JA, Shen PJ, Gundlach AL, Grills BL. Expression of galanin and galanin-1 receptor in normal rat bone and during fracture repair. Bone 2003;33:788-797.

lic MZ, Carter P, Tyndall A, Dudhia J, Handley CJ. Proteoglycans and catabolic products of proteoglycans present in ligament. Biochemical Journal 2005;385:381-388.

Samiric T, Ilic MZ, Handley CJ. Characterization of proteoglycans and their catabolic products in tendon and explant cultures of tendon. Matrix Biology 2004;23:73-140.

 



Prof Chris Handley