Publications
Book Chapters
Vaux, D (2010) BcL-2 Family Proteins - Key Regulators and Effectors of Apoptosis, Cell Death, 69-75.
Vaux, D (2010) Inhibitor of Apoptosis (IAP) and BIR-containing proteins, Cell Death, 138-147.
Vince, J and Silke, J (2010) Apoptosis: Regulatory Genes and Disease, Cell Death, 197-211.
Journal Articles
Abu Bakar, N, Klonis, N, Hanssen, E, Chan, C and Tilley, L (2010) Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum, Journal of Cell Science, 123, 441-450.
Adnan, N, Buck, D, Evison, B, Cutts, S, Phillips, D and Grant Collins, J (2010) DNA binding by pixantrone, Organic and Biomolecular Chemistry, 8, 5359-5366.
Anders, R, Adda, C, Foley, M and Norton, R (2010) Recombinant protein vaccines against the asexual blood stages of Plasmodium falciparum, Human Vaccines, 6, 39-53.
Augusteyn, R (2010) On the growth and internal structure of the human lens, Experimental Eye Research, 90, 643-654.
Ballard, W, Melvin, R, Lazarou, M, Clissold, F and Simpson, S (2010) Cost of a naturally occurring two-amino acid deletion in cytochrome c oxidase subunit 7A in Drosophila simulans, The American Natural-ist, 176, E1-E11.
Broemer, M, Tenev, T, Rigbolt, K, Hempel, S, Blagoev, B, Silke, J, Ditzel, M and Meier, P (2010) Systematic in vivo RNAi analysis identifies IAPs and NEDD8-E3 Ligases, Molecular Cell, 40, 810-822.
Chacinska, A, van der Laan, M, Mehnert, C, Guiard, B, Mick, D, Hutu, D, Truscott, K, Wiedemann, N, Meisinger, C, Pfanner, N and Rehling, P (2010) Distinct forms of mitochondrial TOM-TIM supercom-plexes define signal-dependent states of preprotein sorting, Molecular and Cellular Biology, 30, 307-318.
Chandrashekaran, I, Adda, C, MacRaild, C, Anders, R and Norton, R (2010) Inhibition by flavonoids of amyloid-like fibril formation by Plasmodium falciparum merozoite surface protein 2, Biochemistry, 49, 5899-5908.
Conlan, B, Gillon, A, Craik, D and Anderson, M (2010) Circular proteins and methods of cyclization, Journal of Peptide Science, 94, 573-583.
Covey, P, Subbaiah, C, Parsons, R, Pearce, G, Lay, F, Anderson, M, Ryan, C and Bedinger, P (2010) A pollen-specific RALF from tomato that regulates pollen tube elongation, Plant Physiology, 153, 703-715.
Crespo-Ortiz, M, Tilley, L and Klonis, N (2010) Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine, Journal of Biological Inorganic Chemistry, 15, 1009-1022.
Dougan, D, Truscott, K and Zeth, K (2010) The bacterial N-end rule pathway: expect the unexpected, Molecular Microbiology, 76, 545-558.
Dunse, K, Stevens, J, Lay, F, Gaspar, Y, Heath, R and Anderson, M (2010) Coexpression of potato type I and II proteinase inhibitors gives cotton plants protection against insect damage in the field, Proceedings of the National Academy of Sciences, 107, 15011-15015.
Dunse, K, Kaas, Q, Guarino, R, Barton, P, Craik, D and Anderson, M (2010) Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor, Proceedings of the National Academy of Sciences, 107, 15016-15021.
Duquez, J, Nachbur, U, Cook, W, Gentle, I, Moujalled, D, Moulin, M, Wong, W, Khan, N, Chau, D, Callus, B, Vince, J, Silke, J and Vaux, D (2010) TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kB dependent induction of cFLIPL, PLoS One, 5, e1-e9.
Feltham, R, Moulin, M, Vince, J, Mace, P, Wong, W, Carter, H, Day, C, Vaux, D and Silke, J (2010) Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding, Journal of Biological Chemistry, 285, 17525-17536.
Fu, Y, Tilley, L, Kenny, S and Klonis, N (2010) Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes, Cytometry. Part A, 77, 253-263.
Gill, J, Kumar, A, Yogavel, M, Belrhali, H, Jain, S, Rug, M, Brown, M, Maier, A and Sharma, A (2010) Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum, Malaria Journal, 9, E1-E15.
Hanssen, E, Carlton, P, Deed, S, Klonis, N, Sedat, J and DeRisi, J (2010) Whole cell imaging reveals novel modular features of the exomembrane system of the malaria parasite, Plasmodium falciparum, International Journal for Parasitology, 40, 123-134.
Hanssen, E, Goldie, K and Tilley, L (2010) Ultrastructure of the asexual blood stages of Plasmodium falciparum, Methods in Cell Biology, 96, 93-116.
Hanssen, E, McMillan, P and Tilley, L (2010) Cellular architecture of Plasmodium falciparum-infected erythrocytes, International Journal for Parasitology, 40, 1127-1135.
He, C, Nora, G, Schneider, E, Kerr, I, Hansell, E, Hirata, K, Gonzalez, D, Sajid, M, Boyd, S, Hruz, P, Cobo, E, Le, C, Liu, W-t, Eckmann, L, Dorrestein, P, Houpt, E, Brinen, L, Craik, C, Roush, W, McKerrow, J and Reed, S (2010) A novel entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target, Journal of Biological Chemistry, 285, 18516-18527.
Hrmova, M, Stone, B and Fincher, G (2010) High-yield production, refolding and a molecular modelling of the catalytic module of (1,3)-beta-D-glucan (curdlan) synthase from Agrobacterium sp, Glycoconju-gate Journal, 27, 461-476.
Joachim Schirra, H, Guarino, R, Anderson, M and Craik, D (2010) Selective removal of individual disulfide bonds within a potato type II serine proteinase inhibitor from nicotiana alata reveals differential stabilization of the reactive-site loop, Journal of Molecular Biology, 395, 609-626.
Kimura, K, Spencer, D, Bilardi, R, Swift, L, Box, A, Brownlee, R, Cutts, S and Phillips, D (2010) Barminomycin, a model for the development of new anthracyclines, Anti-Cancer Agents in Medicinal Chemistry, 10, 70-77.
Klonis, N, Dilanian, R, Hanssen, E, Darmanin, C, Streltsov, V, Deed, S, Quiney, H and Tilley, L (2010) Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin, Biochemistry, 49, 6804-6811.
Koutsopoulos, O, Laine, D, Osellame, L, Chudakov, D, Parton, R, Frazier, A and Ryan, M (2010) Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks, Biochimica et Biophysica Acta, 1803, 564-574.
Kulzer, S, Rug, M, Brinkmann, K, Cannon, P, Cowman, A, Lingelbach, K, Blatch, G, Maier, A and Przyborski, J (2010) Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte, Cellular Microbiology, 12, 1398-1420.
Lazarou, M, Stojanovski, D, Frazier, A, Kotevski, A, Dewson, G, Craigen, W, Kluck, R, Vaux, D and Ryan, M (2010) Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane Anchor, Journal of Biological Chemistry, 285, 36876-36883.
Lovric, M, and Hawkins, C (2010) TRAIL treatment provokes mutations in surviving cells, Oncogene, 29, 5048-5060.
Mace, P, Smits, C, Vaux, D, Silke, J and Day, C (2010) Asymmetric recruitment of cIAPs by TRAF2, Journal of Molecular Biology, 400, 8-15.
Mansour, O, Evison, B, Sleebs, B, Watson, K, Nudelman, A, Rephaeli, A, Buck, D, Grant Collins, J, Bilardi, R, Phillips, D and Cutts, S (2010) New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation, Journal of Medicinal Chemistry, 53, 6851-6866.
McKenzie, M and Ryan, M (2010) Assembly factors of human mitochondrial complex I and their defects in disease, IUBMB Life, 62, 497-502.
Pachlatko, E, Rusch, S, Muller, A, Hemphill, A, Tilley, L, Hanssen, E and Beck, H (2010) MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer’s cleft tethers, Molecular Microbiology, 77, 1136-1152.
Poon, I, Parish, C and Hulett, M (2010) Histidine-rich glycoprotein functions cooperatively with cell sur-face heparan sulfate on phagocytes to promote necrotic cell uptake, Journal of Leukocyte Biology, 88, 559-569.
Poon, I, Hulett, M and Parish, C (2010) Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via Fc RI on phagocytes, Blood, 115, 2473-2482.
Poon, I, Yee, D, Jones, A, Wood, R, Davis, D, Freeman, C, Parish, C and Hulett, M (2010) Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions, International Journal of Biochemistry and Cell Biology, The, 42, 1507-1516.
Poon, I, Hulett, M and Parish, C (2010) Molecular mechanisms of late apoptotic/necrotic cell clearance, Cell Death and Differentiation, 17, 381-397.
Ramp, A, Hall, C and Orian, J (2010) Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis, Laboratory Animals, 44, 271-273. Richard, D, MacRaild, C, Riglar, D, Chan, J-A, Foley, M, Baum, J, Ralph, S, Norton, R and Cowman, A (2010) Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites., Journal of Biological Chemistry, 285, 14815-14822.
Riley, L, Cooper, S, Hickey, P, Rudinger-Thirion, J, McKenzie, M, Crompton, A, Lim, S, Thornburn, D, Ryan, M, Giege, R, Bahlo, M and Christodoulou, J (2010) Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia-MLASA Syndrome, American Journal of Human Genetics, 87, 52-59.
Truscott, K, Lowth, B, Strack, P and Dougan, D (2010) Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation, Biochemistry and Cell Biology, 88, 97-108.
Ugarenko, M, Nudelman, A, Rephaeli, A, Kimura, K, Phillips, D and Cutts, S (2010) ABT-737 over-comes Bcl-2 mediated resistance to doxorubicin-DNA adducts, Biochemical Pharmacology, 79, 339-349.
Van Der Weerden, N, Hancock, R and Anderson, M (2010) Permeabilization of Fungal Hyphae by the Plant Defensin NaD1 occurs through a cell wall-dependent process, Journal of Biological Chemistry, 285, 37513-37520.
Vaux, D (2010) Apoptogenic factors released from mitochondria, Biochimica et Biophysica Acta, 1, E1-E5.
Walker, A, Farg, M, Bye, C, McLean, C, Horne, M and Atkin, J (2010) Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis, Brain, 133, 105-116.
Weston, R and Puthalakath, H (2010) Endoplasmic reticulum stress and BCL-2 family members, Advances in Experimental Medicine and Biology, 687, 65-77.
Wong, W, Boutros, P, Wasylishen, A, Guckert, K, O'Brien, E, Griffiths, R, Martirosyan, A, Bros, C, Jurisica, I, Langler, R and Penn, L (2010) Characterization of the apoptotic response of human leukemia cells to organosulfur compounds, BMC Cancer, 10, E1-E14.
Wong, W, Gentle, I, Nachbur, U, Carter, H, Vaux, D and Silke, J (2010) RIPK1 is not essential for TNFR1-induced activation of NF-kappB, Cell Death and Differentiation, 17, 482-487.
Yang, X, Adda, C, MacRaild, C, Low, A, Yang, X, Zeng, W, Jackson, D, Anders, R and Norton, R (2010) Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2), Biochimie, 92, 1287-1295.
Yeap, Y, Ng, I, Badrian, B, Nguyen, T-V, Yip, Y, Dhillon, A, Mutsaers, S, Silke, J, Bogoyevitch, M and Ng, D (2010) c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18, Biochemical Journal, 43, 345-354.