Research/interests
Publications
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RESEARCH/INTERESTS

Effects of polysulfonated polysaccharides on aggrecan catabolism.

Aggrecan is a major structural molecule in articular cartilage that undergoes loss in joint diseases such as osteoarthritis. At present, there are no drugs that can be pharmacologically employed to alter the disease progression of osteoarthritis. This research investigates the effects of polysulfated molecules on aggrecan degration in vitro. The results of this research may have clinical implications in the pharmacologic management of joint diseases.

PUBLICATIONS

Journal Articles

Payne, C, Munteanu, S E & Miller, K, Position of the Subtalar Joint Axis and Resistance of the Rearfoot to Supination, Journal of the American Podiatric Medical Association, 93 (2), 2003, 131-135.

Munteanu, S.E, Ilic, M.Z., and Handley, C.J. Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures, Matrix Biology, Vol 21, Issue 5, pp 429-440, 2002.

Munteanu. S.E., Iilic, M.Z., Handley, C.J. (2000). Calcium pentosan plysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures. Arthritis & Rheumatism Volume 43(10): 2211 - 8.

Payne, C., Munteanu, S., Miller, K. (2003) Position of the subtalar joint axis and resistance of the rear foot to supination. Journal of the American Podiatric Medical Association 93 (2): 131-5.

Conference Publications

Bassed, A, Payne, C & Munteanu, S, Supination resistance, Foot Posture Index and effect of foot orthoses on first MPJ range of motion., in Australasian Podiatry Council(ed/s), Book of Abstracts 20th Australasian Podiatry Conference. (Australasian Podiatry Council: Collingwood, Victoria, Australia, 2003) 36.

Bassed, A., Munteanu, S., Payne, C. (2003) Effect of foot posture and Blake inverted orthoses on maximum first metatarsophalangeal joint dorsiflexion, 20th Australasian Podiatry Conference, Perth, Australia, 13-17 May, 2003.

Handley, C.J., Munteanu, S., & Ilic M.Z. Suppression of aggrecanase mediated degradation of aggrecan by highly sulfated polysaccharides, 2002 Annual Meeting of Matrix Biology Society of Australia and New Zealand, Vol 26, p20, Wiseman's Ferry, Australia, 25-28 September 2002.

Munteanu, S.E., Ilic, M.Z., and Handley, C.J. (2002). Short-term exposure of explant cultures of articular cartilage to pentosan polysulfate results in long-term protection to aggrecan loss, Osteoarthritis Research International, Vol 10 supplement A, p 545, Sydney Australia, 25-28 September 2002.

Iilic, M., Vankemmelbeke, M.N., Bull, M.E., Samiric, T., Munteanu, S.E., Buttle, D.J., Robinson, H.C., Handley, C.J. (1999). Connective tissues of synovial joints express aggrecanase. 4th Symposium Pan-Pacific Connective Tissue Societies. Queenstown N.Z. 15 - 19 November 1999.

Munteanu, S., Iilic, M.Z., Handley, C.J.(1999). Calcium pentosan polysulfate inhibits aggrecan catabolism in bovine cartilage explant cultures. 4th World Congress of the Osteoarthritis Research Society International. Vienna Austria. 16 -19 September 1999.

Iilic M.Z., Vankemmelbeke, M.N., Bull, M.E., Samiric, T., Munteanu, S.E., Buttle, D.J., Robinsong, H.C. & Handley, C.J. (1999). Aggrecanase is expressed by supporting connective tissues that make up synovial joints. 4th World Congress of the Osteoarthritis Research Society International. Vienna Austria. 16 -19 September 1999.

Munteanu, S.E., Iilic, M.Z., & Handley, C.J. (1999). Pentosan Polysulfate inhibits aggrecan catabolism in cartilage. 4th Symposium Pan-Pacific Connective Tissue Societies. Queenstown, N.Z. , 15-19 November 1999.

Munteanu, S.E., Iilic, M.Z., Vankemmelbeke, M.H., Holen , I., Buttle, J., Robinson, H.C., Handley, C.J. Aggrecanases in joint capsule. Matrix Biology Society of Australia and New Zealand, 24th Annual Scientific Conference. Stradbroke Island, Qld, 28 September - 1 October 2000.