Staff profile

Dr Ross O'Shea

Senior Lecturer

Faculty of Health Sciences

School of Public Health and Human Biosciences
Department of Human Biosciences

HS2-443, Melbourne (Bundoora)

 

Qualifications

BSc (Hons), University of Melbourne PhD, University of Melbourne

Area of study

Anatomy and Physiology

Teaching units

  • Pharmacology
  • Neuroscience

Recent publications

Journal Articles

Lau CL†, Perreau VM†, Chen MJ, Cate HS, Merlo D, Cheung NS, O'Shea RD† and Beart PM† (2011) Transcriptomic profiling of astrocytes treated with the rho kinase inhibitor Fasudil reveals cytoskeletal and pro-survival responses. Journal of Cellular Physiology, In Press 10/05/2011.

Lau CL†, O’Shea RD†, Broberg BV, Bischof L and Beart PM (2011) The Rho kinase inhibitor Fasudil upregulates astrocytic glutamate transport subsequent to actin re-modelling in cultured murine astrocytes. British Journal of Pharmacology, 163: 533-545.

Lau CL, Beart PM and O'Shea RD (2010) Transportable and non-transportable inhibitors of L-glutamate uptake produce astrocytic stellation and increase EAAT2 cell surface expression. Neurochemical Research, 35:735-742.

Farso MC, O'Shea RD and Beart PM (2009) Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture. Neurochemical Research, 34: 1721-1728.

Zagami CJ, Beart PM, Wallis N, Nagley P and O'Shea RD (2009) Major role for astrogliosis in amyotrophic lateral sclerosis: oxidative and excitotoxic insults exert differential effects on motoneurons and astrocytic glutamate transporters. Glia, 57: 119-35.

Aprico K, Beart PM, Crawford D and O’Shea RD (2007) Comparison of [3H]-(2S,4R)-4-methylglutamate and [3H]D-aspartate as ligands for binding and autoradiographic analyses of glutamate transporters. Neurochemistry International, 51: 507-516

Beart PM and O'Shea RD (2007) Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement. British Journal of Pharmacology, 150: 5-17.

Cimarosti H†, O’Shea RD†, Jones NM, Horn AP, Simão F, Zamin LL, Nassif M, Frozza R, Netto CA, Beart PM and Salbego C (2006) The effects of estradiol on estrogen receptor and glutamate transporter expression in organotypic hippocampal cultures exposed to oxygen-glucose deprivation. Neurochemical Research, 31: 483 - 490.

O’Shea RD, Lau CL, Farso MC, Diwakarla S, Zagami CJ, Svendsen BB, Feeney SJ, Callaway JK, Pow DV, Danbolt, NC, Jarrott B and Beart PM (2006) Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1. Neurochemistry International, 48: 604-610.

Cimarosti H, Jones NM, O'Shea RD, Pow DV, Salbego C and Beart PM (2005) Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alpha. Neuroscience Letters, 385: 52-57. 

Zagami CJ, O'Shea RD, Lau CL, Cheema SS and Beart PM (2005). Regulation of glutamate transporters in astrocytes: evidence for a relationship between transporter expression and astrocytic phenotype. Neurotoxicity Research, 7: 143-149.