Staff profile

Dr Jarrod Church

Lecturer

Faculty of Health Sciences

School of Public Health and Human Biosciences
Department of Human Biosciences

HS2-424, Melbourne (Bundoora)

 

Qualifications

BSc (Biomed) (Hons) Monash, PhD Monash

Membership of professional associations

Australian Physiological Society (AuPS), American Physiological Society (APS), Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)

Area of study

Anatomy and Physiology

Brief profile

Jarrod obtained his PhD in pharmacology at Monash University in 2002 and worked as a researcher at the University of Cambridge (UK), Georgia Health Sciences University (USA) and the University of Melbourne before joining the Department of Human Biosciences as a Lecturer in 2011. He has a long-standing interest in cell and molecular physiology and intracellular signalling pathways, and currently investigates ways that these pathways can be manipulated to treat musculoskeletal pathologies.

Teaching units

  • HBS1HBA Human Biosciences A
  • HBS2PTA & HBS2PTB Human Physiology Theory A & B (co-cordinator HBS2PTB)
  • HBS2PPA & HBS2PPB Human Physiology Practical A & B (co-cordinator HBS2PPB)
  • HBS3APA & HBS3APB Advanced Physiology A & B
  • HBS3PCY Foundations in Pharmacology for Podiatrists
  • HBS4HPA Human Physiology & Anatomy Honours

Recent publications

Journal Articles (last 10 years)

Gehrig SM, van der Poel C, Sayer TA, Schertzer JD, Henstridge DC, Church JE, Lamon S, Russell AP, Davies KE, Febbraio MA, Lynch GS (2012). Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature, 484: 394-398.

Murphy KT, Ham DJ, Church JE, Naim T, Trieu J, Williams DA, Lynch GS (2012). Parvalbumin gene transfer impairs skeletal muscle contractility in old mice. Hum Gene Ther, in press.

Church, JE, Gehrig SM, Chee A, Naim T, Trieu J, McConnell GK & Lynch GS (2011). Early functional muscle regeneration after myotoxic injury in mice is unaffected by nNOS absence. Am J Physiol Reg Int, 301: R1358-1366.

Church JE, Qian J, Kumar S, Black SM, Venema RC & Fulton D (2010). Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. Vasc Pharmacol, 52: 191-198.

Qian J, Zhang Q, Church JE, Stepp D, Rudic RD & Fulton D (2010). Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation. Am J Physiol Heart Circ Physiol, 298: H112–H118.

Ryall JG, Church JE & Lynch GS (2010). A novel role for β-adrenoceptor signalling in skeletal muscle growth, development and regeneration. Clin Exp Pharmacol Physiol, 37: 397-401.

Koopman R, Ryall JG, Church JE & Lynch GS (2009). The role of β-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders. Curr Opin Clin Nutr Metab Care, 12: 601-606.

Urmaliya VB, Church JE, Coupar IM, Rose'Meyer RB, Pouton CW & White PJ (2009). Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves co-operative activation of adenosine A2A and A2B receptors by endogenous adenosine. J Cardiovasc Pharmacol, 53: 424-433.

Tovey SC, Dedos SG, Taylor EJA, Church JE & Taylor CW (2008). Selective coupling of Type 6 Adenylyl Cyclase with Type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. J Cell Biol, 183: 297-311.

Jagnandan D, Church JE, Banfi B, Marrero MB & Fulton D (2007). Novel mechanism of activation of NADPH Oxidase 5 (NOX5): Calcium-sensitization via phosphorylation. J Biol Chem, 282: 6494-6507.

Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC & Fulton D (2006). Functional relevance of Golgi and plasma membrane localized endothelial nitric oxide synthase (eNOS) in reconstituted endothelial cells. Arterioscl Thromb Vasc Biol, 26: 1015-1021.

Church JE & Fulton D (2006). Differences in eNOS activity due to subcellular localization are dictated by phosphorylation state rather than proximity to plasma membrane Ca2+ channels. J Biol Chem, 281: 1477-1488.

Fulton D, Church JE, Ruan L, Li C, Sood S, Kemp BE, Jennings IG & Venema RC (2005). SRC kinase activates endothelial nitric oxide synthase by phosphorylating TYR-83. J Biol Chem, 280: 35943-35952.

Church JE, Moldrich RX, Beart PM & Hodgson WC (2003). Modulation of intracellular Ca2+ levels by Scorpaenidae venoms. Toxicon, 41: 679-689. 

Church JE & Hodgson WC (2003). Stonefish (Synanceia trachynis) antivenom: in vitro efficacy and clinical use. Journal of Toxicology - Toxin Reviews, 22: 69-76.

 

Conference presentations (last 3 years)

Gehrig SM, van der Poel C, Henstridge DC, Sayer TA, Schertzer JD, Church JE, Lamon S, Russell AP, Febbraio MA & Lynch GS (2011). Muscle-specific HSP72 over-expression improves muscle structure and function in mdx dystrophic mice. Proc. Aust. Phys. Soc., 42, 21P

Zaitsev V, Church JE, Allen AM, Naim T, Koopman R& Lynch GS (2011). Cardiovascular and skeletal muscle responses in orchidectimised rats following short-term chronic formoterol administration. Proc. Aust. Phys. Soc., 42, 14P.  

Church JE, Trieu J, Chee A, Gregorevic P & Lynch GS (2011). Unexpected redundancy between β-adrenoceptor subtypes in early muscle regeneration. Proc. Aust. Phys. Soc., 42, 23P.

Gehrig SM, Sayer TA, van der Poel C, Henstridge DC, Schertzer JD, Church JE, Febbraio MA & Lynch GS (2010). Muscle-specific HSP72 over-expression improves muscle structure and function in dystrophic mdx mice. Proc. Aust. Phys. Soc., 41, 163P.

Church JE, Trieu J, Russell AP & Lynch GS (2010). Stimulating the Notch signalling pathway does not improve muscle regeneration after myotoxic injury in dystrophic mice. Proc. Aust. Phys. Soc., 41, 105P.

Church JE, Trieu J, Moore P, Gregorevic P & Lynch GS (2010). β2-adrenoceptors are the dominant subtype involved in early muscle regeneration. Proc. Aust. Phys. Soc., 41, 162P.

Lynch GS, Sheorey R, Church JE, Gregorevic P & Ryall JG (2009). Novel roles for β-adrenergic signalling in skeletal muscle growth and regeneration. Proc. Indian Ocean Rim Muscle Colloquium, p. 28-29.

Research projects

  1. Intracellular signalling pathways influencing skeletal muscle regeneration
  2. Pharmacological treatments to enhance skeletal muscle repair in chronic degenerative conditions or after acute injury