Staff profile
Professor Chris Handley
Emeritus Professor
Faculty of Health Sciences
School of Public Health and Human BiosciencesDepartment of Human Biosciences
Melbourne (Bundoora)
- T: +61 3 9479 5800
- E: c.handley@latrobe.edu.au
Qualifications
BA (Hons) York., PhD Bristol., DSc York., DipEd Monash
Area of study
Anatomy and Physiology
Research interests
Bone and Cartilage
- Please contact me to discuss a topic.Recent Publications
Parkinson J., Samiric T., Ilic M.Z., Cook J., Feller J.A. and Handley C.J. (2010) Changes in proteoglycan metabolism is a characteristic of human patellar tendinopathy. Arthritis and Rheumatism, 62, 3028-3035
Posthumus M., Collins M., Cook J., Handley C.J., Ribbans W.J., Smith R.K.W., Schwellnus M.P. and Raleigh S.M. (2010). Components of the transforming growth factor β family and the pathogenesis of human Achilles tendon pathology – a genetic study. Rheumatology, 49, 2090-2097.
Samiric T., Parkinson J., Ilic M.Z., Cook J., Feller J.A. and Handley C.J. (2009). Changes in the composition of the extracellular matrix in patellar tendinopathy. Matrix Biology, 28, 230-236
Munteanu S.E., Menz H.B., Zammit G.V., Landorf K.B., Handley C.J., Elzarka A. and, Deluca J. (2009). Efficacy of intra-articular hyaluronan (Synvisc(R)) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus): study protocol for a randomised placebo controlled trial. J Foot Ankle Res. 16, 2:2.
September A.V., Cook J., Handley C.J., van der Merwe L., Schwellnus M.P., and Collins M. (2009). Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. British Journal Sports Medicine, 43, 357-365.
Scott A., Lian Ø, Roberts C.R., Cook J.L., Handley C.J., Bahr R., Samiric T., Ilic M.Z., Parkinson J., Hart D.A., Duronio V. and Khan K.M. (2008). Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee. Scandinavian J Medicine and Science in Sports, 18, 427-435
Ilic, M.Z., Martinac, B., Samiric, T, Handley, C.J. (2008) Effects of glucosamine on proteoglycan loss by tendon, ligament and joint capsule explant cultures. Osteoarthritis Cartilage, 16, 1501-1508
Ilic M.Z., East C.J., Rogerson F.M., Fosang A.J. and Handley C.J. (2007) Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice. Journal of Biological Chemistry. 282, 37420-37428.
Samiric. T, Ilic, M.Z and Handley C.J (2006). Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon. FEBS Journal 273, 3479–3488.
Ilic, M.Z., Carter, P., Tyndall, A., Dudhia, J and Handley, C.J. (2005). Proteoglycans and catabolic products of proteoglycans present in ligament. Biochemical Journal, 385, 381-388.
Samiric, T., Ilic, M.Z. and Handley C.J. (2004). Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon. European Journal of Biochemistry, 271, 3612-3620.
Samiric, T., Ilic, M.Z. and Handley C.J. (2004). Characterization of proteoglycans and their catabolic products in tendon and explant cultures of tendon. Matrix Biology, 23, 73-140.
Vankemmelbeke M.N., Jones G.C., Fowles C., Ilic M.Z., Handley C.J., Day A.J., Knight C.G., Mort J.S. and Buttle D.J. (2003). Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. European Journal of Biochemistry, 270, 2394-2403.
Handley, C.J., Winter, G.M., Ilic, M.Z., Ross, J.M., Poole C.A., and Robinson, H.C. (2002) Distribution of newly synthesized aggrecan in explant cultures of bovine cartilage treated with retinoic acid. Matrix Biology, 21, 579-592.
Handley, C.J. Mok, M.T., Ilic, M.Z., Adcocks, C., Buttle, D.J. and Robinson H.C. (2001). Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH. Matrix Biology, 20, 543-553.
Munteanu, S.E, Ilic, M.Z., Handley, C.J. (2002). Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures. Matrix Biol. 21, 429-440
Vankammelbeke, M.N., Holen, I., Wilson, A.G., Ilic, M.Z., Handley, C.J., Kelner, G.S., Clark, M., Liu, C., Maki, R.A., Burnett, D. and Buttle, D.J. (2001). Expression and activity of ADAMTS-5 in synovium. Eur. J. Biochemistry, 268, 1259-1268.
Munteanu, S.E., Ilic, M.Z. and Handley C.J. (2000). Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures. Arthritis. Rheumatism, 43, 2211-2218.
Ilic, M.Z., Vankemmelbeke, M., Holen, I., Buttle, D.J., Robinson, H.C. and Handley, C.J. (2000). Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity. Matrix Biology, 19, 257-265.
Winter, A.D., Campbell M.A., Robinson, H.C. and Handley, C.J. (2000). Catabolism of newly synthesized decorin by explant cultures of bovine ligament. Matrix Biology, 19, 129-138.


