Staff profile

Dr Brian Grills

Associate Professor in Pathophysiology, Honours Coordinator

Faculty of Health Sciences

School of Public Health and Human Biosciences
Department of Human Biosciences

HS2-430, Melbourne (Bundoora)

 

Qualifications

BSc Hons (Pathology) Melb, PhD Melb

Membership of professional Associations

• Australian and New Zealand Bone and Mineral Society • American Society for Bone and Mineral Research • Federation of American Societies for Experimental Biology • International Society for Bone and Mineral Research • International Osteoporosis Foundation • International Society of Bone Morphometry • International Society for Musculoskeletal and Neuronal Interactions

Area of study

Anatomy and Physiology

Research interests

Bone and Cartilage

- Biological aspects of bone physiology, bone disease and fracture healing

Teaching Units

HBS2PAT - Pathophysiology

HBS3PAP - Pathophysiology and Pharmacology  (coordinator)

HBS3PAN - Pathophysiology, Anatomy and Neurosciences (Pathophysiology instance coordinator)

HBS3PPO - Pathophysiology for Prosthetics and Orthotics (coordinator)

HBS3APA - Advanced Human Physiology A: Pathophysiology and Pharmacology

HBS3APB - Advanced Human Physiology B: Pathophysiology and Pharmacology

HBS4HPA - Honours in Human Physiology and Anatomy (coordinator)

Recent Publications

Journal Articles

McDonald S.J., Dooley P.C., McDonald A.C., Schuijers J.A., Ward A.R. and Grills B.L (2012). Transient expression of myofibroblast-like cells in rat rib fracture callus. Acta Orthop 83: 93-98.

McDonald S.J., Dooley P.C., McDonald A.C., Djouma E., Schuijers J.A., Ward A.R. and Grills B.L. (2011). The α1 adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo. J. Orthop. Res. 29: 740-745.

Doyle D.J., McDonald S.J., McDonald A.C., Schuijers J.A., Ward A.R. and Grills B.L. (2011). Possible direct role of dopamine in healing of fractured bone. Osteoporosis Int 22(Suppl 4): S641-642.  

McDonald S.J., Dooley P.C., McDonald A.C., Djouma E., Schuijers J.A., Ward A.R. and Grills B.L. (2010). The α1 adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo. J. Orthop. Res. 29: 740-745. 

McDonald S.J., Dooley P.C., McDonald A.C., Schuijers J.A., Ward A.R. and Grills B.L. (2009). Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: Implications for fracture healing. J. Orthop. Res. 27: 1508-1513.

Smith, S., Tinley, P., Gilheany, M., Grills, B. Kingsford, A. (2007). The inferior calcaneal spur - Anatomical and histological considerations. The Foot 17: 25–31.

McDonald, A.C., Schuijers, J.A., Gundlach, A.L. and Grills, B.L. (2007) Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFα and GalR2 mRNA induced by chronic daily injections of an injurious vehicle. Bone 40: 895-903.

Dooley, P.C., Howgate, M.L., Schuijers, J.A. and Grills, B.L. (2004 and 2005). Early callus of fractured rib of rat contracts and relaxes ex vivo.  J. Orthop. Res. 22: 1063-1071, 2004 Erratum (Colour photographs) 23: 499-500, 2005.

Yao, M., Dooley, P.C., Schuijers, J.A. and Grills, B.L. (2004). The effects of hypothyroidism on nerve growth factor and norepinephrine concentrations in weight-bearing and non-weight-bearing bones of rats.  J. Musculoskel. Neuron. Interact.  4:319-324.

McDonald, A.C., Schuijers, J.A., Shen, P-J., Gundlach, A.L., Grills, B.L. (2003). Expression of galanin and galanin-1 receptor in normal rat bone and during fracture repair. Bone: 33:788-797.

Conference Publications

Grills B.L (2012). (Invited speaker). The smooth muscle-like nature of early, soft bone fracture callus and its possible role in fracture healing. Proc 7th Clare Valley Bone Meeting.

Brady, R.D., McDonald, S.J., Schuijers, J.A., Ward, A.R. and Grills, B.L. (2012). Thymosin β4 administration enhances fracture healing in mice. Proc 7th Clare Valley Bone Meeting.

McDonald, S.J., Dooley, P.C., McDonald, A.C., Schuijers, J.A., Ward, A.R. and Grills, B.L. (2010). Endothelin-1 receptor and myofibroblast-like cells in early soft callus: a potential role in fracture healing. Proc. ANZBMS, 20: 115.

Eeles D.G., Saleh H., Grills B.L., Schuijers J.A., Gillespie M.M. and Quinn J.M.W. (2011). Osteoblast IL-33 mRNA is regulated by PTH, and IL-33 treatment both increases osteoblast matrix mineralisation and reduces osteoclast formation in vitro. 36th Lorne Conference on Protein Structure and Function.

Blazeska, M., Chan V., Jois M., McDonald A.C., Ward A.R., Schuijers J.A., and Grills B.L. (2010). The angiotensin converting enzyme inhibitor, captopril, reduces bone quality in ovary-intact rats but not in ovariectomized rats. Proc. ANZBMS, 20: 114.

McDonald S.J., Dooley P.C., McDonald A.C., Schuijers J.A., Ward A.R. and Grills B.L. (2010). Identification of myofibroblast-like cells in early, soft fracture callus.Proc 6th Clare Valley Bone Meeting. P3.

Chan V., Jois M., McDonald A.C., Schuijers J.A., and Grills B.L. (2010). Short-term treatment with the ace-inhibitor, captopril, reduces bone loss in an osteoprotic model. .Proc 6th Clare Valley Bone Meeting. P4.

McDonald S.J., Dooley P.C., McDonald A.C., Schuijers J.A., Ward A.R. and Grills B.L. (2008). Transient upregulation of certain smooth muscle-associated proteins in osteoprogenitor cells of early, soft fracture callus: implications for the fracture repair process. Proc. ANZBMS, 18: 81.

McDonald, S.J., Dooley, P.C., McDonald, A.C., Schuijers, J.A., Ward, A.R., Grills, B.L. (2008). The α1 adrenergic receptor agonist phenylephrine potentiates contraction of early rat rib fracture callus ex vivo. Proc 5th Clare Valley Bone Meeting. P3.

McDonald, S.J., Dooley, P.C., McDonald, A.C., Schuijers, J.A., Ward, A.R. and Grills, B.L. (2007). Early, soft fracture callus exhibits the smooth muscle-associated traits of stress-relaxation and reverse stress-relaxation: implications for the fracture repair process. Proc. ANZBMS, 17.