Driving down the cost of biosensing through mobile detection and paper microfluidic sensors
Mobile phone based biosensor for Nicotinamide Adenine Dinucleotide (NADH): Driving down the cost of biosensing through mobile phone detection and paper microfluidic sensors.
Most current enzyme detection methods fall into two categories:
- either high-performance, quantitative methods that are slow and require a laboratory;
- inexpensive, but low accuracy or non-quantitative devices such as test strips or lateral-flow type sensors.
La Trobe University researchers are aiming to bridge this gap by developing low-cost high-performance sensors. To date, the research team has developed a low cost paper-based microfluidic biosensor to detect the coenzyme Nicotinamide Adenine Dinucleotide (NADH), which can be controlled via a mobile phone. The principle is based on electrochemiluminescence, which is the use of electricity to initiate luminescent emission. The research has shown that by impregnating the paper sensor with a suitable light producing molecule, we can use the audio jack in a phone to provide the necessary voltage while simultaneously detecting the resultant emission with the phone's camera. Because NADH is a gateway analyte involved in many enzyme-substrate reactions, its detection provides (in principle) a pathway to indirectly detect a range of other biologically important compounds such as ethanol and glucose.
- Instrument-free with quantitative detection of NADH at a very low cost.
- Good potential for telemedicine applications, as the results of the analysis can easily be transmitted to a doctor or medical database
- Medical diagnostics
- Personalised medicine.
This technology is available at no cost as an Easy Access Licence to companies and individuals.
For more information contact the Project Manager:
Natalia Alvarez Lopez
Senior Commercialisation Coordinator