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Dept Comp Sci & Comp Eng
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La Trobe University
Victoria 3086
AUSTRALIA
Tel: +61 3 9479 1107
Fax: +61 3 9479 3060
Email: info
@cs.latrobe.edu.au
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Research - Current Postgraduates - Details
Department of Computer Science & Computer Engineering
| Li, Xi |
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Course:
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PhD |
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Research Title/Topic:
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Mining Regulatory DNA Motifs in Brassica |
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Supervisor:
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Assoc. Prof. Justin Wang and Dr. Zhen He |
Description:
The special sequential patterns and significant biological meaning of regulatory elements have lead to motif discovery becoming a major research area in Bioinformatics. The identification and classification of regulatory elements (motifs) offers one possible approach to monitor the interacting process among a range of transcription factors to control the transcription efficiency of gene expression. Furthermore it provides the better understanding of gene regulatory network and gene functional analysis. The accomplishment of current motif discovery approaches are usually limited by the great sequence variety and self-performance weakness of selected models. Brassica is known as containing more important agricultural and horticultural crops than other genus, such as Rapeseed and Mustard greens. My research is mainly focus on the Fuzzy Logic approach and Genetic Algorithm in discovering regulartory elements in Brassica promoter regions, which could accelerate experimental identification of new regulatory genes and the gene regulatory network construction.
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