Honours Projects 2010
Dr David Wilson
Drug Design of kinase inhibitors
(with Prof. Bob Brownlee and Dr Belinda Abbott)Computational modelling of biological systems is a useful tool in the design of new drugs. In this project, we are interested in studying the interaction (and inhibition) of the PDK1 and JAK kinases. Designing a drug that could inhibit these kinases could have implications in the therapeutic treatment of diabetes and certain cancers. There are two aspects to this project: modelling drug-enzyme interactions, and synthesising new drug molecules. It is possible to combine both aspects in a joint project, or to focus on either the modelling or synthesis only. Synthesis will be carried out under the supervision of Dr Belinda Abbott.
The RM1 drug bound to the active site of PDK1