Honours Projects 2010
Dr Belinda Abbott
Novel Inhibitors of Phosphodiesterase 2
Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of cellular function. 2 Morpholinochromones (such as LY294002 shown) have been found to inhibit human phosphodiesterases PDE2 and PDE3. Initial screening of related analogues suggest increases in potency and selectivity can be made through relatively small structural modifications.
The aim of this project is to synthesise a library of novel 2-morpholinochromone analogues for evaluation as novel, potent and specific inhibitors of PDE2. It may also be possible to be involved in some computational docking and assay work.