Coordination chemistry of amide containing molecules

The amide or peptide functional group is critical to life and provide the linkage between adjacent amino acid residues in proteins. Amides also display interesting coordination chemistry, where the nitrogen atom can deprotonate and coordinate to a metal ion.

We are developing novel ligands incorporating amide groups in combination with other donors such as amines and NHCs. A particular focus is the synthesis of new cage ligands incorporating amide groups. We recently reported a triamidetriamine macrobicyclic cage ligand and evaluated its potential for radiopharmaceutical applications in combination with the positron emitting isotope: Cu-64.