Publications

For a complete list of publications see:
ResearcherID

Browne, EC and Abbott, BM (2016) Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting, Eur J Med Chem., doi:10.1016/j.ejmech.2016.02.048.

Buskes, MJ, Harvey KL, Richards BJ, Kalhor R, Christoff RM, Gardhi CK, Littler DR, Cope ED, Prinz B, Weiss GE, OBrien NJ, Crabb BS, Deady LW, Gilson PR and Abbott BM (2016) Antimalarial activity of novel 4-​cyano-​3-​methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation, Org Biomol Chem., 14(20): 4617-39.

Buskes, MJ, Harvey KL, Prinz B, Crabb BS, Gilson PR, Wilson DJD and Abbott BM (2016) Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum, Bioorg Med Chem., 24(11): 2389-96.

Browne, EC, Parakh S, Duncan LF,  Langford SJ, Atkin JD and Abbott BM (2016) Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis, Bioorg Med Chem., 24(7): 1520-27.

Soares da Costa TP, Christensen JB, Desbois S, Gordon SE, Gupta R, Hogan CJ, Nelson TG, Downton MT, Gardhi CK, Abbott BM, Wagner J, Panjikar S and Perugini MA (2015) Quaternary structure analyses of an essential oligomeric enzyme, Method Enzymol., 562: 205-23.

O'Brien NJ, Brzozowski M, Buskes MJ, Deady LW and Abbott BM (2014) Synthesis and biological evaluation of 2-​anilino-​4-​substituted-​7H-​pyrrolopyrimidines as PDK1 inhibitors, Bioorg Med Chem., 22(15): 3879-86.

O'Brien NJ, Brzozowski M, Wilson DJD, Deady LW and Abbott BM (2014) Synthesis and biological evaluation of substituted 3-​anilino-​quinolin-​2(1H)​-​ones as PDK1 inhibitors, Bioorg Med Chem., 22(14): 3781-90.

O'Brien NJ, Brzozowski M, Wilson DJD, Deady LW and Abbott BM (2014) Synthesis and biological evaluation of substituted 2-​anilino-​7H-​pyrrolopyrimidines as PDK1 inhibitors, Tetrahedron, 70(33): 4947-56.

Brzozowski M, O'Brien NJ, Wilson DJD, Deady LW and Abbott BM (2014) Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors, Tetrahedron, 70(2): 318-26.

Maharani R, Hughes AB, Brownlee RTC, Abbott BM (2014) A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]- Aureobasidin L using solid-phase methods, Tetrahedron, 70(2): 2351-58.

O'Brien NJ, Amran S, Medan J, Cleary B, Deady LW, Jennings IG, Thompson PE and Abbott BM (2013) Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms, ChemMedChem, 8(6): 914-18.

Browne EC, Langford SJ and Abbott BM (2013) Synthesis and effects of conjugated tocopherol analogues on peptide nucleic acid hybridisation, Org Biomol Chem., 11(39): 6744-50.

Browne EC, Langford SJ and Abbott BM (2012) Peptide nucleic acid monomers: a convenient and efficient synthetic approach to Fmoc​/Boc monomers, Aus J Chem., 65(5): 539-44.