Research specialisations and labs
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Anderson lab - Plant innate immunity proteins
We have been working on three groups of plant innate immunity proteins. All are disulphide-rich proteins and potent insecticidal or antifungal molecules.
Atkin lab - Mechanisms of neurotoxicity in neurodegenerative diseases
Our research is focused on the role of cellular trafficking and endoplasmic reticulum (ER) stress in the pathology of Motor Neuron Disease.
Chen lab - T cell immunology
My Lab in general focuses on T cell biology and vaccine development.
Cutts lab - Cellular responses to anthracycline-DNA lesions
Our projects focus on finding a new mechanism to prevent anthracycline-induced cardiotoxicity while maintaining anticancer activity, and the development of tumour targeted nanoparticles for activation of anthracyclines.
Dougan lab - AAA+ machines in protein homeostasis
We are interested in a group of proteins referred to as AAA+ proteases that are responsible for general (protein quality control) and regulated protein turn over in bacteria and in some organelles of eukaryotes such as mitochondria.
Foley/Anders lab - Anti-malarial therapeutics
The main goal of our group is to understand, at the molecular level, the biology of infectious diseases, including malaria and anthrax, and to use this information to aid the development of new diagnostic and therapeutic approaches to these diseases.
Hawkins lab - Cell death pathways and cancer
Our group works to characterise cell death pathways in normal, cancerous and virally infected cells.
Heras lab - Bacterial virulence factors: structure and function
We are interested in understanding the molecular mechanisms underlying Gram-negative bacterial infections in order to develop antibacterial drugs with novel modes of action not susceptible to existing resistance mechanisms.
Hoogenraad lab - Stress response in mammalian cells
Our interests have centred on the mechanism of import of proteins into mitochondria of mammalian cells, particularly the role of molecular chaperones in this process and the broader function of mitochondria.
Hulett lab - Cancer metastasis, angiogenesis and inflammation
Understanding the molecular basis of cell invasion and angiogenesis is vital to develop strategies to combat cancer spread and inflammatory disease.
Kvansakul lab - Structural biology of cell death and host-pathogen interactions
We are interested in understanding the molecular mechanism underlying virus-mediated inhibition of apoptosis using X-ray crystallography, a technique that allows us to visualise the molecules responsible for apoptosis inhibition at the atomic level.
Maher lab - Metallobiology
My research focuses on the structural biology of metals in biological systems, with particular emphasis on the technique of X-ray crystallography.
Mathivanan lab - Exosomes, secretome and systems biology
Our major research interests are in exploring colorectal cancer cells in the context of molecular mechanisms responsible for the pathological condition and for detecting biomarkers.
Orian lab - Neurodegenerative diseases
Multiple Sclerosis (MS) remains a poorly understood disorder. The primary cause of the disease is unknown and its course remains unpredictable.
Parker lab - Cancer microenvironment and immunology
The Cancer Microenvironment and Immunology laboratory investigates crosstalk between cancer cells and the surrounding microenvironment that promotes cancer invasion and metastasis and can be targeted therapeutically to block spread to distant tissues.
Perugini lab - Lysine biosynthesis enzymes as novel antibiotic targets
The Perugini laboratory studies the structure, function, regulation and inhibition of essential oligomeric enzymes from the lysine biosynthesis pathway in bacteria, including DHDPS, DAPE and DAPDC.
Puthalakath lab - Regulation of apoptosis by Bcl-2 family proteins
We are currently trying to understand the regulation of Bim expression during cardiomyocyte apoptosis leading to heart failure.
Ryan lab - Mitochondrial biogenesis and disease
Our research focuses on four main areas: mitochondrial morphology and distribution, respiratory chain complexes and mitochondrial disease, protein import into mitochondria, and mitochondrial outer membrane permeabilization in apoptosis.
Simpson lab - Colorectal cancer secretome & exosome biology
We are using an integrated proteomic/genomic strategy directed towards colorectal cancer biomarker discovery.
Truscott lab - Mitochondrial protein homeostasis
My lab studies the fundamental biological activity that maintains protein homeostasis.
