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Truscott Laboratory
Department of Biochemistry
Biosketch - Kaye Truscott
Kaye graduated from La Trobe University with a Bachelor of Science and a Diploma in Education. After developing a strong interest in protein biochemistry while working in the Centre for Protein and Enzyme Technology within the Biochemistry Department at La Trobe University Kaye chose to study thermophilic molecular chaperones for her doctorate under the supervision of Prof. Robert Scopes. In 1999, shortly after obtaining her PhD Kaye was awarded a Humboldt Research Fellowship to study protein import channels in the inner membrane of yeast mitochondria in the lab of Prof. Nikolaus Pfanner in the Institute for Biochemistry and Molecular Biology, Freiburg, Germany. In 2001 Kaye was promoted to group leader within the Pfanner lab where she continued her studies on the molecular mechanisms of mitochondrial inner membrane protein translocation. In 2004 she was awarded a QEII Fellowship by the Australian Research Council to work further on understanding the mechanisms of protein recognition, unfolding and translocation within the research field of AAA+ proteins.
Selected publications
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Frazier A.E, Dudek J., Guiard B., Voos W., Li Y., Lind M., Meisinger C., Geissler A., Sickmann A., Meyer H.E., Bilanchone V., Cumsky M.G., Truscott K.N., Pfanner N., Rehling P. (2004). Pam16 has an essential role in the mitochondrial protein import motor. Nature Struct. Mol. Biol. 11, 226-233.
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Truscott K.N., Voos W., Frazier A.E., Lind M., Li Y., Geissler A., Dudek J., Muller H., Sickmann A., Meyer H.E., Meisinger C., Guiard B., Rehling P., Pfanner N. (2003). A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J. Cell Biol. 163, 707-713.
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Rehling P., Model K., Brandner K., Kovermann P., Sickmann A., Meyer H.E., Kuhlbrandt W., Wagner R., Truscott K.N., Pfanner N. (2003). Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science . 299, 1747-1751.
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Truscott, K.N., Wiedemann, N., Rehling, P., Müller, H., Meisinger, C., Pfanner, N. and Guiard, B. (2002). Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol. Cell. Biol. 22, 7780-7789.
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Geissler, A., Chacinska, A., Truscott, K.N., Wiedemann, N., Brandner, K., Sickmann, A., Meyer, H.E., Meisinger, C., Pfanner, N. and Rehling, P. (2002). The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell 111, 507-518.
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Kovermann, P., Truscott, K.N., Guiard, B., Rehling, P., Sepuri, N.B., Müller, H., Jensen, R.E., Wagner, R. and Pfanner, N. (2002). Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. Mol. Cell 9, 363-373.
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Truscott, K.N., Kovermann, P., Geissler, A., Merlin, A., Meijer, M., Driessen, A.J.M., Rassow, J., Pfanner, N. and Wagner, R. (2001). A voltage-activated channel of the mitochondrial presequence translocase formed by Tim23. Nature Struct. Biol . 8, 1074-1082.
Honours & Awards
Note: If you are a German scholar, holding a doctorate and not older than 38 you can apply for a Feodor Lynen Research Fellowship through the AvH Foundation to carry out research in Kaye's lab. Please contact Kaye for further details.
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