Science, Technology and Engineering

Phillips Laboratory

Department of Biochemistry

Publications

Swift, L.P., Rephaeli, A., Nudelman, A., Phillips, D.R. and Cutts, S.M. (2008) The cardio-protecting agent and topoisomerase II inhibitor subuzoxane enhances doxorubicin-DNA mediated cytotoxicity. Cancer Chemoth Pharm, 61, 739-749.

Spencer, D.M.S., Bilardi, R.A., Koch, T.H., Post, G.C., Nafie, J.W., Kimura, K-I, Cutts, S.M. and Phillips, D.R. (2008) DNA Repair in Response to Anthracycline-DNA adducts: A role for both Homologous Recombination and Nucleotide Excision Repair, Mutation Res., 638, 110-121.

Levovich I, Nudelman A, Berkovitch G, Swift LP, Cutts SM, Phillips DR and Rephaeli A (2008) Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellulat glutathione and augmentation of reactive oxygen species. Cancer Chemoth Pharm, in press (DOI 10 1007/s00280-007-0627-0).

Evison BJ, Pezzoni G, Phillips DR and Cutts SM (2008) Formaldehyde-activated pixantrone selectively alkylates DNA at CpG and CpA dinucleotide sequences. Mol Pharmacol, in press (DOI 10.1124/mol.108.045625).

Cutts SM, Pillay V,  Nudelman A, Rephaeli A, Swift L and Phillips DR. (2007) Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug Pivaloyloxymethyl butyrate. Mol. Cancer Therapeutics, 6, 1450-1459.

Evison BJ, Mansour O, Menta E, Phillips DR and Cutts SM. (2007) Pixantrone can be activated by formaldehyde to generate a potent DNA-adduct forming agent. Nucleic Acids Res., 35, 3581-3589.

Rephaeli, A, Waks-Yona S, Nudelman, A, Tarasenko I, Tarasenko N, Phillips, DR, Cutts, SM and Kessler-Icekson G. (2007) Anticancer prodrugs of butyric acid formaldehyde protect against doxorubicin induced cardiotoxicity. Brit. J. Cancer, 96, 1667-1674.|

Rephaeli, A., Entin-Meer, M., Angel, D., Tarasenko, N., Gruss-Fischer, T., Bruachman, I., Phillips, D.R., Cutts, S.M, Haas-Kogan, D. and Nudelman, A. (2006) The selectivity and anti-metastatic activity of oral bioavailable butyric acid prodrugs. Investig. New Drugs, 24, 383-392.

Engel, D., Nudelman, A., Levovich, I., Gruss-Fischer, T., Phillips, D.R., Cutts, S.M. and Rephaeli, A. (2006) Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines. J. Cancer Res. Clin. Oncol., 132, 673-683.

Swift, L.P., Rephaeli, A., Nudelman, A., Phillips, D.R. and Cutts, S.M (2006) Doxorubicin-DNA adducts induce a non-topoisomerase II mediated form of cell death. Cancer Res., 66, 4863-4871.

Cutts, S. M., Nudelman, A., Rephaeli, A. and Phillips, D. R. (2005) Recent advances in understanding and exploiting the activation of anthracyclines by formaldehyde. Current Medicinal Chemistry – Anti-Cancer Agents , 5 , 431-447.

Cutts, S.M., Nudelman, A., Pillay, V., Spencer, D.M.S., Levovich, I., Rephaeli, A. and Phillips, D.R. (2005) Formaldehyde-releasing prodrugs in combination with Adriamycin can overcome cellular drug resistance, Oncology Res ., 15 , 199-213.

Rephaeli, A., Blank-Porat, D., Terasenko, N., Entin-Meer, M., Levovich, I., Cutts, S. M., Phillips, D. R. and Nudelman, A. (2005) In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, on human prostate cancer. Internat. J. Cancer., 116, 226 - 235.

Cutts, S. M., Nudelman, A., Rephaeli, A. and Phillips, D. R. (2005) The power and potential of doxorubicin-DNA adducts. IUBMB Life., 57, 73 - 81.

Nudelman, A., Levovich, I., Cutts, S. M., Phillips, D. R. and Rephaeli, A. (2005) The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkylesters. J. Med. Chem., 48, 1042-1054.

Parker, BS, Rephaeli, A, Nudelman, A, Phillips, DR, Cutts SM (2004) Formation of mitoxantrone adducts in human tumor cells: Potentation by AN-9 and DNA methylation. Oncology Res., 14, 279-290.

Parker, BS, Buley, T, Evison, BJ, Cutts, SM, Neumann, GM, Iskander, MI, and Phillips, DR (2004) A molecular understanding of mitoxantrone-DNA adduct formation: Effect of cytosine methylation and flanking sequences. J. Biol. Chem., 279, 18814-18823.

Wheate, N.J., Evison, B.J., Herlt, A.J., Phillips, D.R. and Collins, J.G. (2003) DNA binding of the anti-cancer platinum complex trans-[{Pt(NH3)2Cl}2µ-dpzm]2+ Dalton Trans., 3486-3492.

Swift, L.P., Cutts, S.M., Rephaeli, A. Nudelman, A. and Phillips, D.R. (2003) Activation of Adriamycin by the pH dependent formaldehyde-releasing prodrug hexamethylenetetramine. Mol. Cancer Therapeutics, 2, 189-198.

Cutts, S.M., Swift, L.P., Rephaeli, A., Nudelman, A. and Phillips, D.R. (2003) Sequence specificity of Adriamycin-DNA adducts in human tumour cells. Mol. Cancer Therapeutics, 2, 661-670.

Parker, B.S., Cutts, S.M., Nudelman, A., Rephaeli, A., Phillips, D.R. and Sukamar, S. (2003) Mitoxantrone mediates demethylation and re-expression of cyclin D2, estrogen receptor and 14.3.3sigma in breast cancer cells. Cancer Biol. Therapy, 2, 259-263.

Moufarij, M.A., Phillips, D.R. and Cullinane, C. (2003) Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines. Mol. Pharmacol., 63, 862-869.

Spencer, D.M.S., Cutts, S.M., Kimura, K., Gray, P.J. and Phillips, D.R. (2003) Detection of labile anthracycline-DNA adducts by real-time PCR. Oncology Res., 13, 479-489.

Ilinski, P., Lai, B, Cai, Z, Yun, W, Legnini, D, Talarico, T,.Cholewa, M, Webster, L.K., Deacon, G.B., Rainone, S., Phillips, D.R and Stampfl A.P.J. (2003) The use of synchrotron radiation for the detection of platinum anti-cancer agents in human ovarian adenocarcinoma cells. Cancer Res., 63, 1776-1779.

Phillips, D.R., Cullinane, C.M., (2002) Adriamycin In: Encyclopedia of Molecular Biology.
Creighton, T.E. (Ed), John Wiley and Sons, New York.

Moufarij, M.A., Phillips, D.R. and Cullinane, C. (2002) Inhibition of repair of cisplatin-induced DNA damage by gemcitabine in 2008 ovarian cancer cells. In “Research Trends in Science and Technology”, Kabbani A. and El-Kasser, A. (Eds), Lebanese American University Press, Beirut, pp161-176.

Cholewa, M., Dillon, C., Lay, P., Phillips, D., Talarico, T. and Lai, B. (2001) High resolution nuclear and X-ray microprobes and their applications in single cell analysis. Nuc. Inst. Methods Phys. Res., 181, 715-722.

Cutts, S.M., Rephaeli, A., Nudelman, A., Hmelnitsky, I. and Phillips, D.R. (2001) Molecular Basis for the Synergistic Interaction of Adriamycin with the Formaldehyde-releasing Prodrug Pivaloyloxymethyl Butyrate (AN-9). Cancer Research, 61, 8194-8202.

Wheate, N. J., Cutts, S. M., Phillips, D. R., Aldrich-Wright, J. R. and Collins, J. G. (2001) The binding of [(en) Pt(u-dpzm)2Pt(en)] 4t to G/C rich regions of DNA. Journal of Inorganic Biochemistry 84, 119-127.

Phillips, D. R., Cutts, S. M., Cullinane, C. M. and Crothers, D. M. (2001) High-resolution transcription assay for probing drug-DNA interactions at individual drug sites. Methods in Enzymology 340, 466-485.

Parker, B. S., Cutts, S. M. and Phillips, D. R. (2001) Cytosine methylation enhances mitoxantrone-DNA adduct formation at CpG dinucleotides. Journal of Biological Chemistry 276, 15953-15960.

Moufarij, M.A., Cutts, S.M., Neumann, G.M., Kimura, K-I. and Phillips D.R. (2001) Barminomycin functions as a potent pre-activated analogue of Adriamycin. Chemico-Biol. Interactions, 138, 137-153.

Talarico, T., Cullinane, C.M., Gray, P.J., Webster, L.K., Deacon, G.B. and Phillips, D.R. (2001) Nuclear and mitochondrial distribution of organoamidoplatinum(II) lesions in cisplatin sensitive and resistant adenocarcinoma cells. Anti-Cancer Drug Design, 16, 135-141.

Phillips, D.R. and Cullinane, C. Adriamycin (2001) In "Encyclopedia of Molecular Biology On-line", Creighton, T.E. (Ed), John Wiley and Sons, New York.

Sharples, R. A., Cullinane, C. and Phillips, D. R. (2000) Adriamycin-induced inhibition of mitochondrial-encoded polypeptides as a model system for the identification of hotspots for DNA-damaging agents. Anti-Cancer Drug Design 15, 183-190.

Perrin, L. C., Prenzler, P. D., Cullinane, C., Phillips, D. R., Denny, W. D. and McFadyen, W. D. (2000) DNA targeted platinum complexes: Synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum (II) complexes tethered to phenazine-1-carboxamides. Journal of Inorganic Biochemistry 81, 111-117.

Parker, B. S., Cutts, S. M., Cullinane, C. and Phillips, D. R. (2000) Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts. Nucleic Acids Research 28, 982-990.

Ferguson, L. R., Liu, A. P., Denny, W. A., Cullinane, C., Talarico, T. and Phillips, D. R. (2000) Transcriptional blockages in a cell-free system by sequence-selective DNA alkylating agents. Chemico-Biological Interactions 126, 15-31.

Cutts, S. M., Parker, B. S., Swift, L. P., Kimura, K.-I. and Phillips, D. R. (2000) Structural requirements for the formation of anthracycline-DNA adducts. Anti-Cancer Drug Design 15, 373-386.

Cullinane, C., Cutts, S. M., Panousis, C. and Phillips, D. R. (2000) Interstrand cross-linking by Adriamycin in nuclear and mitochondrial DNA of MCF-7 cells. Nucleic Acids Research 28, 1019-1025.

Talarico, T., Phillips, D. R., Deacon, G. B., Rainone, S. and Webster, L. K. (1999) Activity and DNA binding of new organoamidoplatinum (II) complexes. Investigational New Drugs 17, 1-15.

Phillips, D. R. and Cullinane, C. (1999) Adriamycin, In Encyclopedia of Molecular Biology (Ed, Creighton, T.) John Wiley and Sons, New York, pp. 68-72.

Perrin, L. C., Cullinane, C., McFadyen, W. D. and Phillips, D. R. (1999) Sequence specificity and reactivity of the binding of phenazine-tethered platinum complexes to DNA. Anti-Cancer Drug Design 14, 243-252.

Perrin, L. C., Cullinane, C., Kimura, K. and Phillips, D. R. (1999) Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA. Nucleic Acids Research 27, 1781-1787.

Parker, B. S., Cullinane, C. and Phillips, D. R. (1999) Formation of DNA adducts by formaldehyde-activated mitoxantrone. Nucleic Acids Research 27, 2918-2923.

Custer, L., Zajc, B., Sayer, J. M., Cullinane, C., Phillips, D. R., Cheh, A. M., Jerina, D. M.,
Bohr, V. A. and Mazur, S. J. (1999) Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomerase located within the human K-ras codon 12 sequence. Biochemistry 38, 569-581.

Cullinane, C., Mazur, S. J., Essigman, J. M., Phillips, D. R. and Bohr, V. A. (1999) Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage. Biochemistry 38, 6204-6212.

Chen, X.-M., Cullinane, C., Gray, P. J. and Phillips, D. R. (1999) DNA damage by nitrogen mustard in a gene containing multiple Sp1-binding sites. Mutation Research 445, 45-54.

Chen, X.-M., Gray, P. J., Cullinane, C. and Phillips, D. R. (1999) Differential sensitivity of transcription factors to mustard-damaged DNA. Chemico-Biological Interactions 118, 51-67.

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