Science, Technology and Engineering

Lock Laboratory

Department of Biochemistry

Publications

Stylli, S.S., I, S.T., Kaye, A.H., and Lock, P. Prognostic significance of Tks5 expression in gliomas. J Clin Neurosci (2011), doi:10.1016/j.jocn.2011.11.013. (in press).

Stylli, S.S. I, S.T.T., Verhagen, A.M., Xu S., Pass, I., Courtneidge, S.A., and Lock, P.* (2009). Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. J Cell Sci 122, 2727-2740. *corresponding author.

Stylli, S.S., Kaye A.H., and Lock P*. (2008). Invadopodia: At the cutting edge of tumour invasion. J Clin Neurosci. 15, 725-37. *corresponding author.

Lock, P.,* I, S.T.T., Straffon, A.F., Schieb, H., Hovens, C.M. and Stylli, S.S. (2006). Spred-2 steady state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. Biochem. Biophys. Res. Commun. 351, 1018-23. *corresponding author.

Chan, J., Clements, W. Field, J., Nasa, Z., Lock P., Yap, F., Toh, B-H., and Alderuccio, F. (2006). Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice. J. Gene Med, 8, 1281-90.

King, J.A., Corcoran, N.M., D’Abaco, G.M., Straffon, A.F., Smith, C.M., Poon, C.L. Buchert, M., I, S., Hall, N.E., Lock, P., and Hovens, C.M. (2006). Eve-3: a liver enriched suppressor of Ras/MAPK signalling. J. Hepatol. 44, 758-67

King, J.A., Straffon, A.F., D'Abaco, G.M., Poon, C.L., I, S.T., Smith, C.M., Buchert, M., Corcoran, N.M., Hall, N., Callus, B.A., Sarcevic, B., Martin, D., Lock, P., Hovens, C.M. (2005). Distinct requirements for the Sprouty domain for functional activity of Spred proteins. Biochem J. 388, 445-454.

I, S.T.T, Nie, Z, Stewart, A., Hall, N.E., Najdovska, M., He, H., Randazzo, P.A., and Lock, P*. (2004). ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP dependent manner. J. Cell Sci. 117, 6071-6084. *corresponding author.

Grumont, R, Lock, P., Mollinari, M., Shannon, F., and Gerondakis, S. (2004). The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-kB-Dependent c-myc Expression. Immunity 21, 19-30.

Abud, H.E., Lock, P. and Heath, J.K. (2004). Efficient Gene Transfer Into the Epithelial Cell Layer of Embryonic Mouse Intestine Using Low-Voltage Electroporation. Gastroenterology 126, 1779-1787.

Gugasyan, R., Quilici, C., I, S.T.T, Grail, D., Verhagen, A.M., Roberts, A., Kitamura, T., Dunn, A.R. and Lock, P. (2002). Dok-Related Protein Negatively Regulates T Cell Development via its RasGTPase-activating Protein and Nck Docking Sites. J Cell Biol. 158, 115-125.

Verhagen, A.M. and Lock, P. (2002). Revealing the intricacies of Cancer. Genome Biology 3, reports 4015.1-4015.5.

Lawrenson, I.D., Wimmer-Kleikamp, S.H., Lock, P., Schoenwaelder, S.M, Down, M., Reed, C., Boyd, A.W., Alewood, P.F., and Lackmann, M. (2002). Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3 expressing 293T and melanoma cells by CrkII and Rho-mediated signaling. J Cell Sci. 115,1059-72.

*Lock, P, Casagranda, F., and Dunn, A.R. (1999).  Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase activating protein and Nck. J. Biol. Chem. 274, 22775-22784. *corresponding author.

Lock, P., Abram, C. L., Gibson, T., and Courtneidge, S.A. (1998).  A new method for isolating tyrosine kinase substrates used to identify FISH, an SH3 and PX domain-containing protein, and Src substrate.  EMBO J. 17, 4346-4357.

Lock, P., Fumagalli, S., Polakis, P., McCormick, F., and Courtneidge, S.A. (1996).  The Human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein. Cell 84,23-4.

Metcalf, D., Willson, T., Rossner, M., and Lock, P. (1995).  Receptor insertion into factor-dependent murine cell lines to develop specific bioassays for murine G-CSF and M-CSF and human GM-CSF. Growth Factors 11, 145-52.

Layton, M.J., Owczarek, C.M., Metcalf, D., Lock, P.A., Wilson, T. A., Gough, N. M., Hilton, D. J., Nicola, N. A. (1994). Complex binding of leukemia inhibitory factor to its membrane-expressed and soluble receptors.  Proc. Soc. Exp. Biol. Med. 206, 295-298.

Layton, M.J., Lock, P., Metcalf, D., and Nicola, N.A. (1994).  Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction.  J. Biol. Chem. 269, 17048-55.

Lock, P., Metcalf, D., and Nicola, N.A. (1994).  Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.  Proc. Natl. Acad. Sci. (USA). 91, 252-6.

Owczareck, C.M., Layton, M.J., Metcalf, D., Lock, P., Wilson, T.A., Gough, N.M., Nicola, N.A. (1993).  Inter-species chimeras of leukemia inhibitory factor define a major human receptor-binding determinant.  EMBO J. 12, 3487-95.

Boulet, I., Ralph, S., Stanley, E., Lock, P., Dunn, A.R., Green, S.P., and Phillips,. W.A. (1992). Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.  Oncogene 7, 703-10.

Lock, P., Ralph, S., Stanley, E., Boulet, I., Ramsay, R., and Dunn, A.R. (1991).  Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.  Mol. Cell.  Biol. 11, 4363-70.

Stanley, E., Ralph, S., McEwen, S., Boulet, I., Holtzman, D.A., Lock, P., and Dunn, A.R. (1991).  Alternatively spliced murine lyn mRNAs encode distinct proteins.  Mol. Cell. Biol. 11, 3399-406.

Lock, P., Stanley, E., Holtzman, D.A., and Dunn, A.R. (1990).  Functional analysis and nucleotide sequence of the promoter region of the murine hck gene.  Mol. Cell. Biol. 10, 4603-11.

Albiston, A.L., Lock, P., Burger, H.G., and Krozowski, Z.S. (1990).  Cloning and characterization of the rat alpha-inhibin gene. Mol. Cell. Endocrinol. 68, 121-8.