Science, Technology and Engineering

Hawkins Laboratory

Department of Biochemistry

Publications

Kitevska T, Spencer DM, Hawkins CJ. Caspase-2: controversial killer or checkpoint controller? Apoptosis. 2009 Jul;14(7):829-48.

Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18081-7.

Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008 Jul 14;182(1):171-84.

Ashley DM, Riffkin CD, Lovric MM, Mikeska T, Dobrovic A, Maxwell JA, Friedman HS, Drummond KJ, Kaye AH, Gan HK, Johns TG, Hawkins CJ. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. Br J Cancer. 2008 Jul 22;99(2):294-304.

Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem. 2008 Jul 11;283(28):19499-510.

Westein SJ, Scott FL, Hawkins CJ. Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system. Biochim Biophys Acta. 2008 Mar;1783(3):448-54.

Puryer, M.A. and Hawkins, C.J. Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p. Apoptosis 11(4):509-17.(2006)

Li, S., Melissa J. Ferguson, M.J., Hawkins, C.J., Smith, C. and Elwood, N.J. Human telomerase reverse transcriptase (hTERT) protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal. Leukemia 20(7):1270-8 (2006)

Jabbour, A.M., Puryer, M.A., Yu, J.Y., Lithgow, T., Ashley, D.M., Vaux, D. L. Ekert, P.G. and Hawkins, C.J. Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. J Cell Sci. 119(12): 2572-82 (2006)

Verhagen, A.M., Kratina, T.K., Hawkins, C.J., Silke, J., Ekert, P.G. and Vaux, D.L. Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs. Cell Death Diff. (Epub June 23rd 2006).

Muscat, A.M., Hawkins, C.J. and Ashley, D.M. Caspase-8 levels correlate with STAT-1 expression in high grade but not lower grade neuroblastoma. Cancer (in press, accepted March 2006).

Ho, P-K., Ekert, P.G., Jabbour, A.M., Hawkins, C.J. Caspase-2 is resistant to inhibition by IAPs and can activate caspase-7. FEBS J. 272(6):1401-14 (2005).

Burri. L., Strahm, Y., Hawkins, C.J., Gentle, I.E., Puryer, M.A., Verhagen, A., Callus, B., Vaux, D., Lithgow, T. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Mol. Biol. Cell 16(6):2926-33 (2005).

Ashley, D.M., Riffkin, C.D., Muscat, A., Knight, M.J., Kaye, A.H., Novak, U. Hawkins, C.J. Caspase-8 is absent or low in many ex vivo gliomas. Cancer. 104(7):1487-96. (2005).

Ho, P-K. & Hawkins, C.J. Mammalian initiator apoptotic caspases. FEBS J. 272(21):5436-53 (2005).

Knight, M.J., Riffkin, C.D., Ekert, P.G., Ashley, D.M. & Hawkins, C.J. Caspase-8 levels affect neccessity for mitochondrial amplification in death ligand induced glioma cell apoptosis. Mol. Carcinog. 39(3):173-82 (2004).

Ekert, P.G., Read, S.H., Silke, J., Marsden, V.S., Kaufmann, H., Hawkins, C.J., Gerl, R., Kumar, S.& Vaux, D.L. Apaf-1, caspase-2 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die. J. Cell Biol. 165(6):835-42. (2004).

Jabbour, A.M., Ho, P-K., Puryer, M.A., Ashley, D.M., Ekert, P.G., Hawkins, C.J. The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. Cell Death Differ. 11(12):1309-16 (2004).

Steel, R., Doherty, J.P., Buzzard, K.A., Clemons, N.J., Hawkins, C.J., Anderson, R.L. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. J.Biol. Chem. 279(49):51490-9 (2004).

Hawkins, C.J. TRAIL and Malignant Glioma. Vitamins Horm. 67, 427-452 (2004).

Jabbour, A. and Hawkins, C.J. The p35 family of apoptosis inhibitors. Current Genomics 5(3), 215-229 (2004).

Knight, M.J. & Hawkins, C.J. Caspases; Modulators of apoptosis and cytokine maturation – targets for novel therapies. In Los, M., Gibson, S. (eds), Apoptosis pathways as targets for novel therapies in cancer and other diseases. Kluwer Academic / Plenum Publishers (2004).

Silke, J., Hawkins, C.J., Ekert, P.G., Chew, J., Day, C.L., Pakusch, M., Verhagen, A.M. & Vaux, D.L. The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. J. Cell Biol. 157: 115-24 (2002).

Jabbour A., Ekert, P.G., Coulson, E.J., Knight, M.J., Ashley, D.M. & Hawkins, C.J. The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death Differ. 9(12):1311-20 (2002).

Ekert, P. G., Silke, J., Hawkins, C.J., Verhagen, A.& Vaux, D.L. DIABLO promotes apoptosis by removing MIHA/XIAP from processed Caspase-9.” J. Cell Biol. 152:483-490 (2001).

Silke J., Ekert P.G., Day, C.L., Hawkins, C.J., Baca M., Chew, J., Pakusch, M., Verhagen, A.M. & Vaux, D.L. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. EMBO J., 20: 3114-3123 (2001).

Hawkins, C.J., Silke, J., Verhagen, A.M., Foster, R., Ekert, P.G. & Ashley, D.M. Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. Apoptosis 6: 331-8 (2001).

Gray, A.Z., Riffkin, C. Hawkins, C.J., Chow, C.W. & Ashley, D.M. Ex vivo paediatric high grade brain tumours express Fas (CD95) and FasL (CD95L) and are resistant to induction of apoptosis. Neuro-Oncology 3: 229-240 (2001).

Knight, M.J., Riffkin, C.D., Muscat, A.M., Ashley, D.M. & Hawkins, C.J. Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. Oncogene 20: 5789-5798 (2001).

Hawkins, C.J., Yoo, S.J., Petersen, E., Wang, S.L, Vernooy, S.Y, & Hay, B.A. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM., J. Biol. Chem., 275: 27084-27093 (2000).

Hawkins, C.J., Wang, S.L., & Hay, B.A. Monitoring the activity of caspases and their regulators in the yeast Saccharomyces cerevisiae, Meth. Enz. 322, 162-74 (2000).

Hawkins, C.J., Wang, S.L., & Hay, B.A. A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1., Proc. Natl. Acad. Sci., 96: 2885-2890 (1999).

Wang, S.L., Hawkins, C.J., Yoo, S.J., Muller, H.A., & Hay, B.A. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by REAPER, HID and GRIM, which disrupt DIAP1-caspase interactions, Cell, 98: 453-463 (1999).

Hawkins, C.J., Coulson, E.J. & Vaux, D.L. Baculoviral lessons in apoptosis. In Watters, D., Lavin, M. (eds), Signalling pathways in apoptosis. The Netherlands: Hardwood Academic Publishers (1999).

Hawkins, C.J., Ekert, P.G., Uren, A.G., Holmgreen, S.P., & Vaux, D.L. Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ., 5: 569-576 (1998).

Hawkins, C.J. & Vaux, D.L. The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system. Sem. Immunol. 9, 25 (1997).

Hawkins, C. J., Uren, A. G., Hacker, G., Medcalf, R. L., & Vaux, D. L. Inhibition of interleukin 1-beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP, Proc. Natl. Acad. Sci. USA, 93: 13786-13790 (1996).

Hacker, G., Hawkins, C.J., Smith, K.G., & Vaux, D.L. Effects of viral inhibitors of apoptosis in models of mammalian cell death., Behring Inst. Mitt., 97: 118-126 (1996).

Uren, A. G., Pakusch, M., Hawkins, C. J., Puls, K. L., & Vaux, D. L. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors, Proc. Natl. Acad. Sci., 93: 4974-4978 (1996).

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