Science, Technology and Engineering

Foley Laboratory

Department of Biochemistry

Publications

Loria, L., Miller, S., FOLEY, M., and Tilley, L. (1999) Inhibition of the peroxidative deregulation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem. J 339, 363-370

Albano FR., Berman A., La Greca N., Hibbs AR., Wickham M., FOLEY, M and Tilley L (1999) A homologue of Sar1p localises to a novel trafficking pathway in malaria-infected erythrocytes. Eur J Cell Biol 78, 453-62

Adda, C., Tilley, L., Anders, R.F. and FOLEY, M. (1999)Isolation of peptides that mimic epitopes on a malarial antigen from random peptide libraries displayed on phage. Infection and Immun. 67, 4679-4688

Albano, FR., FOLEY, M and Tilley, L. (1999) Export of parasite proteins to the erythrocyte cytoplasm: secretory machinery and traffic signals. Novartis Found Symp. 226,157-72

Casey, J.L., Coley, A.M., Tilley, L.M. and FOLEY, M. (2000) Green fluorescent antibodies: novel in vitro tools. Protein Engineering. 13, 445-452

Tilley, L. and FOLEY, M. (2000) The power of phage, on display in malaria research Today’s Life Science. 12, 20-24

Tilley, L., Loria, P and FOLEY, M. (20001) Chloroquine and other quinoline antimalarials. In Antimalarial Chemotherapy (Rosenthal, P.J., ed) Humana Press, Totowa, N.J. Invited )

Papalexis, V., Campanale, N., Guo, X., Siomos, M., Kocak, G., FOLEY, M., and Tilley, L. (2001) Histidine-rich protein 2 of the malarial parasite, Plasmodium falciparum, is involved in detoxification of the by-products of haemoglobin degradation. Mol. Biochem. Parasitol. 115, 77-86.

Wright AD, Wang H, Gurrath M, Konig GM, Kocak G, Neumann G, Loria P, FOLEY M, Tilley L. (2001) Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges. J. Med. Chem. 44, 873-885

Adisa A, Albano FR, Reeder J, FOLEY M, Tilley L. (2001) Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the export of proteins to the surface of malaria parasite-infected erythrocytes. J Cell Sci. 114, 3377-86

Coley, A., Campanale, N.V., Casey, J., Hodder, A., Crewther, P., Tilley, L Anders, R.F, and FOLEY, M. (2001) Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides. Protein Eng. 14, 691-8.

Adisa A, Rug M, FOLEY M, Tilley L. (2002) Characterisation of a delta-COP homologue in the malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol. 123, 11-21

Vukovic P, Chen K, Qin Liu X, FOLEY M, Boyd A, Kaslow D, Good MF. (2002) Single-chain antibodies produced by phage display against the C-terminal 19 kDa region of merozoite surface protein-1 of Plasmodium yoelii reduce parasite growth following challenge. Vaccine. 20, 2826-35

Nair M, Hinds MG, Coley AM, Hodder AN, FOLEY M, Anders RF, Norton RS. (2002) Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1). J Mol Biol. 322, 741-53

Graves PR, Kwiek JJ, Fadden P, Ray R, Hardeman K, Coley AM, FOLEY M, Haystead TA. (2002) Discovery of novel targets of quinoline drugs in the human purine binding proteome. Mol Pharmacol. 62, 1364-72

Li F, Dluzewski A, Coley AM, Thomas A, Tilley L, Anders RF, FOLEY M. (2002) Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes. J Biol Chem. 277, 50303-10

Adisa A, Rug M, Klonis N, FOLEY M, Cowman AF, Tilley L. (2002) The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites. J Biol Chem. 278, 6532-6542.

Keizer, D.W., Miles, L.A., Li, F., Nair, M., Anders, R.F., Coley, A.M., FOLEY, M., & Norton, R.S. (2003) Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion. Biochemistry 42, 9915 - 9923.

Casey, J.L, Coley, A.M, Anders RF, Murphy V.J, Humberstone, K.S, Thomas A, and FOLEY, M. (2004) Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes. Infection and Immun. 72, 1126-1134

Nuttall, S.D, Humberston, K.S, Krishnan,U.V, Carmichael J.A, Larissa Doughty, L, Hattarki, M, Coley, A.M, Casey, J.L, FOLEY, M, Irving R.A, and Hudson, P.J. (2004) Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1. Proteins Published online 28th Jan 2004

Rug M, Wickham M.E, FOLEY M, Cowman A.F, Tilley L. (2004) Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites. Infect Immun. 2004 72, 6095-105.

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