Publications

Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN and Conway EM (2016) Polyphosphate is a novel cofactor for regulation of complement by the serpin, C1-inhibitor, Blood, 128(13): 1766-76.

Hou L, Cooley J, Swanson R, Ong PC, Pike RN, Bogyo M, Olson ST and Remold-O'Donnell E (2015) The protease cathepsin L regulates Th17 cell differentiation, J Autoimmun., 65: 56-63.

Drentin N, Conroy P, Gunzburg MJ, Pike RN and Wijeyewickrema LC (2015) Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4, Mol Immunol., 67(2 Pt B): 287-93.

Wijeyewickrema LC, Duncan RC and Pike RN (2014) The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates, Front Immunol., 5:444, doi: 10.3389/fimmu.2014.00444.

Reynolds SL, Pike RN, Mika A, Blom AM, Hofmann A, Wijeyewickrema LC, Kemp D and Fischer K (2014) Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway, PLoS Negl Trop Dis., 8(5): e2872.

Hsieh YS, Wijeyewickrema LC, Wilkinson BL, Pike RN and Payne RJ (2014) Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein, Angew Chem Int Ed Engl., 53(15): 3947-51.

Dunstan RA, Heinz E, Wijeyewickrema LC, Pike RN, Purcell AW, Evans TJ, Praszkier J, Robins-Browne RM, Strugnell RA, Korotkov KV and Lithgow T (2013) Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS, PLoS Pathog., 9(1): e1003117.

Langendorf CG, Tuck KL, Key TL, Fenalti G, Pike RN, Rosado CJ, Wong AS, Buckle AM, Law RH and Whisstock JC (2013) Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates, Biosci Rep., 33(1): 137-44.

Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC and Pike RN (2013) A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4, J Biol Chem., 288(22): 15821-29.

Pike RN and Wijeyewickrema LC (2013) The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates, Curr Opin Struct Biol., 23(6): 820-27.

Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, Wijeyewickrema LC, Eckle SB, van Heemst J, Pike RN, McCluskey J, Toes RE, La Gruta NL, Purcell AW, Reid HH, Thomas R and Rossjohn J (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis, J Exp Med., 210(12): 2569-82.

Sivagurunathan S, Pagel CN, Loh LH, Wijeyewickrema LC, Pike RN and Mackie EJ (2013) Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism, J Mol Endocrinol., 50(3): 347-59.

Wijeyewickrema LC, Yongqing T, Tran TP, Thompson PE, Viljoen JE, Coetzer TH, Duncan RC, Kass I, Buckle AM and Pike RN (2013) Molecular determinants of the substrate specificity of the complement-initiating protease, C1r, J Biol Chem., 288(22): 15571-80.

Yongqing T, Wilmann PG, Reeve SB, Coetzer TH, Smith AI, Whisstock JC, Pike RN and Wijeyewickrema LC (2013) The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome, J Biol Chem., 288(31): 22399-407.

Yongqing T, Drentin N, Duncan RC, Wijeyewickrema LC and Pike RN (2012) Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions? Biochim Biophys Acta., 1824(1): 253-62.

Song J, Tan H, Perry AJ, Akutsu T, Webb GI, Whisstock JC and Pike RN (2012) PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites, PLOS One, 7(11): e50300.

Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV and Smooker PM (2012) Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference, Biochimie., 94(5): 1119-27.

Mika A, Reynolds SL, Mohlin FC, Willis C, Swe PM, Pickering DA, Halilovic V, Wijeyewickrema LC, Pike RN, Blom AM, Kemp DJ and Fischer K (2012) Novel scabies mite serpins inhibit the three pathways of the human complement system, PLoS One, 7(7): e40489.

Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB and Whisstock JC (2012) The X-ray crystal structure of full-length human plasminogen, Cell Rep., 1(3): 185-90.

Hsieh YS, Taleski D, Wilkinson BL, Wijeyewickrema LC, Adams TE, Pike RN and Payne RJ (2012) Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin, Chem Commun (Camb)., 48(10): 1547-49.

Georgy SR, Pagel CN, Ghasem-Zadeh A, Zebaze RM, Pike RN, Sims NA and Mackie EJ (2012) Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair, Bone, 50(3): 704-12.

Duncan RC, Mohlin F, Taleski D, Coetzer TH, Huntington JA, Payne RJ, Blom AM, Pike RN and Wijeyewickrema LC (2012) Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s, J Immunol., 189(5): 2365-73.

Duncan RC, Bergstrom F, Coetzer TH, Blom AM, Wijeyewickrema LC and Pike RN (2012) Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4, Mol Immunol., 49(4): 593-600.

Yongqing T, Potempa J, Pike RN and Wijeyewickrema LC (2011) The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition, Adv Exp Med Biol., 712: 15-29.

Wong W, Wijeyewickrema LC, Kennan RM, Reeve SB, Steer DL, Reboul C, Smith AI, Pike RN, Rood JI, Whisstock JC and Porter CJ (2011) S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction, J Biol Chem., 286(49): 42180-87.

Song J, Tan H, Boyd SE, Shen H, Mahmood K, Webb GI, Akutsu T, Whisstock JC and Pike RN (2011) Bioinformatic approaches for predicting substrates of proteases, J Bioinform Comput Biol., 9(1):149-78.

Song J, Matthews AY, Reboul CF, Kaiserman D, Pike RN, Bird PI and Whisstock JC (2011) Predicting serpin/protease interactions, Methods Enzymol., 501: 237-73.

Norbury LJ, Beckham S, Pike RN, Grams R, Spithill TW, Fecondo JV and Smooker PM (2011) Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles, Biochimie., 93(3): 604-11.

Ng NM, Pierce JD, Webb GI, Ratnikov BI, Wijeyewickrema LC, Duncan RC, Robertson AL, Bottomley SP, Boyd SE and Pike RN (2011) Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate, Biochemistry, 50(48): 10499-507.

Horvath AJ, Lu BG, Pike RN and Bottomley SP (2011) Methods to measure the kinetics of protease inhibition by serpins, Methods Enzymol., 501: 223-35.

Beinrohr L, Murray-Rust TA, Dyksterhuis L, Zavodszky P, Gal P, Pike RN and Wijeyewickrema LC (2011) Serpins and the complement system, Methods Enzymol., 499: 55-75.