Publications

Tan JL, Ward L, Truscott KN and Dougan DA (2016) The N-end rule adaptor protein ClpS from Plasmodium falciparum exhibits broad substrate specificity, FEBS Lett., 590: 3397-406.

Bezawork-Geleta A, Brodie EJ, Dougan DA and Truscott KN (2015) LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins, Sci Rep., 5:17397, doi:10.1038/srep17397.

Micevski D, Zammit JE, Truscott KN and Dougan DA (2015) Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP, Front Mol Biosci., doi: 10.3389/fmolb.2015.00015.

Bezawork-Geleta A, Saiyed T, Dougan DA and Truscott KN (2014) Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA, FASEB J., 28(4): 1794-804.

Nagpal J, Tan JL, Truscott KN, Heras B and Dougan DA (2013) Control of protein function through regulated protein degradation: biotechnological and biomedical applications, J Mol Microbiol Biotechnol., 23(4-5): 335-44.

Voos W, Ward L and Truscott KN (2013) The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control, Subcell Biochem., 66: 223-63.

Lowth BR, Kirstein-Miles J, Saiyed T, Brötz-Oesterhelt H, Morimoto RI, Truscott KN and Dougan DA (2012) Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX, J Struct Biol., 179(2): 193-201.

Böttinger L, Gornicka A, Czerwik T, Bragoszewski P, Loniewska-Lwowska A, Schulze-Specking A, Truscott KN, Guiard B, Milenkovic D and Chacinska A (2012) In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins, Mol Biol Cell, 23(20): 3957-69.

Dougan DA, Micevski D and Truscott KN (2012) The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+ proteases, BBA Mol Cell Res., 1823(1): 83-91.

Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N and Wiedemann N (2011) Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane, Mol Cell, 44(5): 811-18.

Truscott KN, Bezawork-Geleta A and Dougan DA (2011) Unfolded protein responses in bacteria and mitochondria: a central role for the ClpXP machine, IUBMB Life, 63(11): 955-63.