Understanding how perturbations in cell polarity affect cell competition in tissue development

When cell shape regulators are perturbed in a cell within a tissue, through mutation or upon wounding, signalling pathways are altered that trigger death of the aberrant cells. Activation of a surveillance mechanism termed "cell competition" is important to remove the damaged cells. We seek to determine how a potential egulator of
cell competition, the tyrosine phosphatase PTP61F, is controlled in response to pertubation of cell shape regulators.

To address this question we are using the vinegar fly, Drosophila, and mammalian systems (in collaboration with Prof Patrick Humbert (LIMS) and Prof Tony Tiganis (Monash).