Publications

For a complete list of publications see:
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Patents

Novel forms of plant defensins: WO 2013/056308

Treatment of proliferative diseases: AU 2011/269726

Treatment of proliferative diseases: WO 2011/160174  A1

Publications

Putz E, Mayfosh A, Kos K, Barkauskas D, Nakamura K, Town L, Goodall K, Yee D, Poon IKH, Baschuk N, Souza-Fonseca-Guimaraes, Hulett MD and Smyth M (2017) Natural killer cell heparanase controls tumor invasion and immune surveillance, J Clin Invest., doi: 10.1172/JCI92958.

Priebatsch KM, Kvansakul M, Poon IKH and Hulett MD (2017) Functional regulation of the plasma protein Histidine-Rich Glycoprotein by Zn2+ in settings of tissue injury, Biomolecules, 7(2): 22.

Tixeira R, Caruso S, Paone S, Baxter AA, Atkin-Smith GK, Hulett MD and Poon IKH (2017) Defining the morphologic features and products of cell disassembly during apoptosis, Apoptosis, 22: 475-77.

Baxter AA, Poon IKH and Hulett MD (2017) The lure of the lipids: how defensins exploit membrane phospholipids to induce cytolysis in target cells, Cell Death Dis., 8(3): e2712.

Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD and Poon IKH (2017) Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting, Sci Rep., 6(7): 39846.

Baxter AA, Poon IKH and Hulett MD (2017) The plant defensin NaD1 induces tumor cell death via a non-apoptotic, membranolytic process, Cell Death Dis., 23(3): 16102.

Priebatsch KM, Poon IKH, Patel KK, Kvansakul M and Hulett MD (2017) Divalent metal binding by histidine-rich glycoprotein (HRG) differentially regulates higher order oligomerisation and proteolytic processing, FEBS Lett., 591(1): 164-76.

Atkin-Smith GK and Poon IKH (2016) Disassembly of the dying: mechanisms and functions, Trends Cell Biol., S0962-8924(16): 30129-35.

Kvansakul M, Lay FT, Adda CG, Veneer PK, Baxter AA, Phan TK, Poon IKH and Hulett MD (2016) Binding of phosphatidic acid by NsD7 mediates formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization, Proc Natl Acad Sci USA, 113(40): 11202-07.

Bleackley MR, Payne JA, Hayes B, Durek T, Craik D, Shafee TM, Poon IKH, Hulett MD, van der Weerden NL and Anderson MA (2016) Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant, Antimicrob Agents Chemother., 60(10): 6302-12.

Payne JA, Bleackley MR, Lee T-H, Shafee TM, Poon IKH, Hulett MD, Aguilar M-I, van der Weerden NL and Anderson MA (2016) The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate, Biochim Biophys Acta, 1858(6):1099-109.

Jiang L, Tixeira R, Caruso S, Atkin-Smith GK, Baxter AA, Paone S, Hulett MD and Poon IKH (2016) Monitoring the progression of cell death and the disassembly of dying cells by flow cytometry, Nat Protoc., 11(4):655-63.

Phan TK, Lay FT, Poon IKH, Hinds MG, Kvansakul M and Hulett MD (2015) Human beta-defensin 3 contains a conserved oncolytic motif that binds PI(4,5)P2 to mediate tumour cell killing, Oncotarget, 7(2): 2054-69.

Baxter AA, Hulett MD and Poon IKH (2015) The phospholipid code: a key component of dying cell recognition, tumor progression and host-microbe interaction, Cell Death Differ., 22(12): 1893-905.

Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD and Poon IKH (2015) A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure, Nature Commun., 6: 7439.

Baxter AA, Richter V, Lay FT, Poon IKH, Adda CG, Veneer PK, Phan TK, Bleackley MR, Anderson MA, Kvansakul M and Hulett MD (2015) The tomato defensin TPP3 binds phosphatidylinositol (4,5)-bisphosphate via a conserved dimeric cationic grip conformation to mediate cell lysis, Mol Cell Biol., 74(20): 5832-45.

Poon IKH, Chiu Y-H, Armstrong AJ, Kinchen J, Juncadella IJ, Bayliss DA and Ravichandran KS (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis, Nature, 507(7492): 329-34.

Poon IKH, Lucas CD, Rossi AG and Ravichandran KS (2014) Apoptotic cell clearance: basic biology and therapeutic potential, Nat Rev Immunol., 4: 166-80.

Poon IKH, Baxter AA, Lay FT, Mills GD, Adda CG, Payne JAE, Phan TK, Ryan GF, White JA, Veneer PK, van der Weerden N, Anderson MA, Kvansakul M and Hulett MD (2014) Phosphoinositide-mediated oligomerization of a defensin induces cell lysis, eLife, 3: e01808.

Byrne FL, Poon IKH, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, Moley KH, Ravichandran KS, Slack-Davis JK and Hoehn KL (2014) Metabolic vulnerabilities in endometrial cancer, Cancer Res., 74(20): 5832-45.

Goodall KJ, Poon IKH and Hulett MD (2014) Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4, PLoS One, 9(10): e109596.

Poon IKH, Goodall KJ, Phipps S, Chow JD, Pagler EB, Andrews DM, Conlan CL, Ryan GF, White JA, Wong MK, Horan C, Matthaei KI, Smyth MJ and Hulett MD (2014) Mice deficient in heparanase exhibit impaired dendritic cell migration and reduce airway inflammation, Eur J Immunol., 44(4): 1016-30.

Kenwood BM, Weaver J, Bajwa A, Byrne F, Poon IK, Murrow BA, Huang L, Divakaruni A, Coleman GC, Ferrick D, Yan Z, Saucerman J, Smith JS, Lynch KR, Santos WL, Ravichandran KS, Rogers GW, Okusa MD, Bayliss DA and Hoehn KL (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane, Mol Metab., 3(2): 114-23.

Patel KK, Poon IKH, Talbo GH, Perugini MA, Taylor NL, Ralph TJ, Hoogenraad NJ and Hulett MD (2013) New method for purifying Histidine-rich glycoprotein from human plasma redefines it functional properties, IUBMB Life, 65: 550-63.

Lay FT, Mills GD, Poon IKH, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M and Hulett MD (2012) Dimerization of the plant defensin NaD1 enhances its antifungal activity, J Biol Chem., 287: 19961-72.

He YQ, Sutcliffe EL, Bunting KL, Li J, Goodall KJ, Poon IKH, Hulett MD, Freeman C, Zafar A, McInnes RL, Taya T, Parish CR and Rao S (2012) The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes, Transcription, 3: 130-45.

Poon IKH, Patel KK, Davis DS, Parish CR and Hulett MD (2011) Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma, Blood, 117(7): 2093-101.