Poon - Apoptotic cell disassembly and clearance

Lab leader

Ivan PoonDr Ivan Poon

Nicholas Hoogenraad Fellow in Molecular Sciences, College of Science, Health and Engineering

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In humans, billions of cells will die daily as part of normal turnover in various organs. It is vital that dying cells are rapidly removed as their accumulation has been linked to inflammation, autoimmunity, cancer and infection. To aid efficient removal of dead cells, dying cells often disassemble into smaller fragments for neighboring cells to engulf. Furthermore, certain cellular components can be packaged selectively into these fragments to regulate tissue repair and immunity.

We aim to understand the machinery that control how dying cells can disassemble into smaller pieces, the importance of cell disassembly in disease settings (e.g. influenza A infection and atherosclerosis), and identify new drugs to control this process.

Research areas