New inhibitors targeting bacterial and plant DHDPS

This project involves testing the in vitro and in vivo potency of small drug-like compounds targeting 'druggable' sites of the essential bacterial enzyme, dihydrodipicolinate synthase (DHDPS). The project will foster the development of multidisciplinary skills including recombinant protein expression and purification, enzymology, analytical ultracentrifugation, circular dichroism spectroscopy, computational design, isothermal titration microcalorimetry, mass spectrometry, microbiological viability assays, microscale thermophoresis, plant molecular biology (in collaboration with Dr Anthony Gendall from AgriBio), X-ray crystallography (in collaboration with Dr Santosh Panjikar from the Australian Synchrotron) and medicinal chemistry (in collaboration with Dr Belinda Abbott from the Department of Chemistry and Physics, La Trobe University). This project will be co-supervised by NHMRC Early Career Fellow Dr Tatiana Soares da Costa.