PsaBCA – manganese uptake by Streptococcus pneumoniae

Manganese is essential for many bacterial species as it is required for enzymes, which respond to oxidative stress. The ABC transporter PsaBCA from Streptococcus pneumoniae is a virulence factor for this organism and is essential for manganese uptake. We are working towards the structure solution of this protein by X-ray crystallography with a view to using it as a scaffold for novel antibiotic design.

Collaborators: Dr Christopher McDevitt, University of Adelaide; Professor So Iwata, Kyoto University; Dr David Aragão, Australian Synchrotron.