Publications

For a complete list of publications see:
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Banjara S, Caria S, Dixon L, Hinds MG and Kvansakul M (2017) Structural insight into African Swine Fever mediated inhibition of apoptosis, J Virol, doi: 10.1128/JVI.02228-16.

Caria S, Hinds MG and Kvansakul M (2017) Crystal structure of BHP2 bound to LB_Bak-2 – structural insight into an evolutionarily ancient programmed cell death regulator, Cell Death Dis., 8(1):e2543.

Priebatsch KM, Poon IK, Patel KK, Kvansakul M* and Hulett MD (2017) Divalent metal binding by histidine-rich glycoprotein differentially regulates higher order oligomerisation and proteolytic processing, FEBS Lett., 591(1): 164-76.

Kvansakul M, Lay FT, Adda CG, Veneer PK, Baxter AA, Phan TK, Poon IK and Hulett MD (2016) Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization, Proc Natl Acad Sci USA, 113(40): 11202-07.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M and Sliz P (2016) Data publication with the structural biology data grid supports live analysis, Nat Comm., 7:10882, doi: 10.1038/ncomms10882.

Kvansakul M and Czabotar PE (2016) Preparing samples for crystallization of Bcl-2 family complexes, Meth Mol Biol., 1419: 213-29, doi: 10.1007/978-1-4939-3581-9_16.

Griffiths K, Dolezal O, Cao B, Nilsson SK, See HB, Pfleger KD, Roche M, Gorry PR, Pow A, Viduka K, Lim K, Lu BG, Chang DH, Murray-Rust TA, Kvansakul M, Perugini MA, Dogovski C, Doerflinger M, Zhang Y, Parisi K, Casey JL, Nuttall SD and Foley M. (2016) i-bodies: human single domain antibodies that antagonize chemokine receptor CXCR4, J Biol Chem., pii: jbc.M116.721050.

Caria S, Marshall B, Burton RL, Campbell S, Pantaki-Eimany D, Hawkins CJ, Barry M and Kvansakul M (2016) The N-terminus of the vaccinia virus protein F1L is an intrinsically unstructured region that is not involved in apoptosis regulation, J Biol Chem., doi: 10.1074/jbc.M116.726851.

Phan TK, Lay FT, Poon IIK, Hinds MG, Kvansakul M and Hulett MD (2015) Human beta-defensin 3 contains a conserved oncolytic motif that binds PI(4,5)P2 to mediate tumour cell killing, Oncotarget, doi:10.18632/oncotarget.6520.

McGrath AP, Laming EM, Casas Garcia GP, Kvansakul M, Guss JM, Trewhella J, Calmes B, Bernhardt PV, Hanson GR, Kappler U and Maher MJ (2015) Structural basis of interprotein electron transfer in bacterial sulfite oxidation, eLife, doi: 10.7554/eLife.09066.

Richter V, Singh AP, Kvansakul M, Ryan MT and Osellame LD (2015) Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission, Cell Mol Life Sci., 72(19): 3695-707.

Burton DR, Caria S, Marshall BM, Barry M and Kvansakul M (2015) Structural basis for Deerpox mediated inhibition of apoptosis, Acta Cryst D Biol Crystallogr., 71(8): 1593-603.

Baxter AA, Richter V, Lay FT, Adda CG, Poon IKH, Veneer PK, Tanh KP, Bleackley MR, Anderson MA, Kvansakul M* and Hulett MD* (2015) The tomato defensin TPP3 specifically binds phosphatidylinositol(4,5)-bisphosphate via a conserved dimeric cationic grip conformation to mediate cell lysis, Mol Cell Biol., 35(11): 1964-78.

Marshall B, Puthalakath H, Caria S, Chugh S, Doerflinger M, Colman PM and Kvansakul M (2015) Variola virus F1L is a Bcl-2 protein with an unexpected BH3-ligand binding profile that acts independent of Bim, Cell Death Dis., 6: e1680.

Kvansakul M and Hinds MG (2015) The Bcl-2 family: structures, interactions, and targets for drug discovery, Apoptosis, 20(2): 136-50.

Campbell S, Thibault J, Mehta N, Colman PM, Barry M and Kvansakul M (2014) Structural insight into BH3-domain binding of vaccinia virus anti-apoptotic F1L, J Virol., 88(15): 8667-77.

North RA, Seizova S, Stampfli A, Kessans SA, Suzuki H, Griffin MDW, Kvansakul M and Dobson RCJ (2014) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus, Acta Cryst F Struct Biol Commun., 70(Pt 5): 643-49.

Richter V, Palmer CS, Osellame LD, Singh AP, Elgass K, Stroud DA, Sesaki H, Kvansakul M and Ryan MT (2014) Structural and functional analysis of MiD51, a dynamin adaptor required for mitochondrial fission, J Cell Biol., 204(4): 477-86.

Kvansakul M and Hinds MG (2014) The structural biology of BH3-only proteins, Method Enzymol., 544: 49-74.

Poon IHK, Baxter AA, Lay FT, Mills GD, Bojceski A, Adda CG, Payne JAE, Ryan GF, White JA, Veneer PK, Wong MKL, van der Weerden NL, Anderson MA Kvansakul M* and Hulett MD* (2014) Nicotiana alata defensin 1 forms an oligomeric complex with phosphatidylinositols in a novel mechanism of cell lysis, elife, 3: e01808.

Kvansakul M and Hinds MG (2013) Structural biology of the Bcl-2 family and its mimicry by viral proteins, Cell Death Dis., 4: e909, doi: 10.1038/cddis.2013.436.

Newman J, Burton BR, Caria S, Desbois S, Gee CL, Fazio VF, Kvansakul M, Marshall B, Mills GD, Richter V, Seabrook SA, Wu M and Peat TS (2013) Crystallization reports are the backbone of Acta Cryst F., but do they have any spine? Acta Cryst F Struct Biol Cryst Commun., 69(Pt 7): 712-18.

Beaumont TE, Shekhar TM, Kaur L, Kvansakul M and Hawkins CJ (2013) Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members, Cell Death Dis., 3: e443

Fleming P, Kvansakul M, Kile BT, Huang DCS, Degli-Eposti MA and Andoniou CE (2013) A single viral open reading frame encodes multiple immune evasion products that act via divergent mechanisms, PLoS Pathogens, 9: e1003192.

Caria S, Srishti C, Nhu D, Lessene G and Kvansakul M (2012) Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 protein in complex with a benzoylurea peptidomimetic, Acta Cryst F Struct Biol Cryst Commun., 68(Pt 12): 1521-24.

Rautureau GJP, Yabal M, Yang H, Huang DCS, Kvansakul M* and Hinds MG* (2012) The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only pro-survival Bcl-2 protein antagonist, Cell Death Dis., 3: e443doi.

Okamoto T, Campbell S, Mehta N, Thibault J, Colman PM, Barry M, Huang DC and Kvansakul M (2012) Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins, J Virol., 86(21): 11501-11.

Brand IL, Civciristov S, Taylor NL, Talbo GH, Pantaki-Eimany D, Levina V, Clem RJ, Perugini MA, Kvansakul M and Hawkins CJ (2012) Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria, PLoS One, 7(6): e39248.

Lay FT, Mills GD, Poon IK, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M and Hulett MD (2012) Dimerization of plant defensin NaD1 enhances its antifungal activity, J Biol Chem., 287(24): 19961-72.

Lay FT, Veneer PK, Hulett MD and Kvansakul M (2012) Recombinant expression and purification of the tomato defensin TPP3 and its preliminary X-ray crystallographic analysis, Acta Crystallogr Sect F Struct Biol Cryst Commun., 68(Pt 3): 314-16.

Lay FT, Mills GD, Hulett MD and Kvansakul M (2012) Crystallization and preliminary X-ray crystallographic analysis of the plant defensin NaD1, Acta Crystallogr Sect F Struct Biol Cryst Commun., 68(Pt 1): 85-88.

Banadyga L, Lam SC, Okamoto T, Kvansakul M, Huang DC, and Barry M (2011) Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax, J Virol., 85(5): 1922-34.

*Contributed equally to work.