Publications

For a complete list of publications see:
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Putz EM, Mayfosh AJ, Kos K, Barkauskas DS, Nakamura K, Town L, Goodall KJ, Yee DY, Poon IKH, Baschuk N, Souza-Fonseca-Guimaraes F, Hulett MD, Smyth MJ (2017) NK cell heparanase controls tumor invasion and immune surveillance, J Clin Invest., doi: 10.1172/JCI92958.

Baxter AA, Poon IK and Hulett MD (2017) The lure of the lipids: how defensins exploit membrane phospholipids to induce cytolysis in target cells, Cell Death Dis., 8(3): e2712.

Priebatsch KM, Kvansakul M, Poon IK and Hulett MD (2017) Functional regulation of the plasma protein histidine-rich glycoprotein by Zn2+ in settings of tissue injury, Biomolecules, 7(1). pii: E22.

Baxter AA, Poon IK and Hulett MD (2017) The plant defensin NaD1 induces tumor cell death via a non-apoptotic, membranolytic process, Cell Death Discov., 3: 16102.

Tixeira R, Caruso S, Paone S, Baxter AA, Atkin-Smith GK, Hulett MD and Poon IK (2017). Defining the morphologic features and products of cell disassembly during apoptosis, Apoptosis, 22(3): 475-77.

Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD and Poon IK (2017) Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting, Sci Rep., 7: 39846.

Priebatsch KM, Poon IK, Patel KK, Kvansakul M and Hulett MD (2017) Divalent metal binding by histidine-rich glycoprotein differentially regulates higher order oligomerisation and proteolytic processing, FEBS Lett., 591(1): 164-76.

Kvansakul M, Lay FT, Adda CG, Veneer PK, Baxter AA, Phan TK, Poon IK and Hulett MD (2016) Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization, Proc Natl Acad Sci USA, 113(40):11202-07.

Shafee TM, Lay FT, Phan TK, Anderson MA and Hulett MD (2016) Convergent evolution of defensin sequence, structure and function, Cell Mol Life Sci., 74(4): 663-82.

Bleackley MR, Payne JA, Hayes BM, Durek T, Craik DJ, Shafee TM, Poon IK, Hulett MD, van der Weerden NL and Anderson MA (2016) Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant, Antimicrob Agents Chemother., 60(10): 6302-12.

Shafee TM, Lay FT, Hulett MD and Anderson MA (2016) The defensins consist of two independent, convergent protein superfamilies, Mol Biol Evol., 33(9): 2345-56.

Jiang L, Tixeira R, Caruso S, Atkin-Smith GK, Baxter AA, Paone S, Hulett MD and Poon IKH (2016) Monitoring the progression of cell death and the disassembly of dying cells by flow cytometry, Nat Protoc., 11(4):655-63.

Payne JA, Bleackley MR, Lee T-H, Shafee TM, Poon IKH, Hulett MD, Aguilar M-I, van der Weerden NL and Anderson MA (2016) The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate, Biochim Biophys Acta, 1858(6):1099-109.

Corbo R, Ryan G, Haghighatbin M, Hogan C, Wilson D, Hulett MD, Barnard P and Dutton J (2016) Access to the parent tetrakis(pyridine)gold(III) trication, facile formation of rare Au(III) terminal hydroxides, and preliminary studies of biological properties, Inorg Chem., 55(6): 2830-39.

Phan TK, Lay FT, Poon IIK, Hinds MG, Kvansakul M and Hulett MD (2015) Human beta-defensin 3 contains a conserved oncolytic motif that binds PI(4,5)P2 to mediate tumour cell killing, Oncotarget, 7(2): 2054-69.

Baxter AA, Hulett MD* and Poon IKH* (2015) The phospholipid code: a key component of dying cell recognition, tumor progression and host-microbe interaction, Cell Death Diff., 22(12): 1893-905.

Kuek LE, Leffler M, Mackay GA and Hulett MD (2015) The MS4A family: counting past 1, 2 & 3, Immunol Cell Biol., 94(1): 11-23.

Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD and Poon IKH (2015) A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure, Nature Comm., 6: 7439.

Baxter AA, Richter V, Lay FT, Poon IKH, Adda CG, Veneer PK, Phan TK, Bleackley MR, Anderson MA, Kvansakul M and Hulett MD (2015) The tomato defensin TPP3 binds phosphatidylinositol (4,5)-bisphosphate via a conserved dimeric cationic grip conformation to mediate cell lysis, Mol Cell Biol., 35(11): 1964-78.

Lee AY, Phan TK, Hulett MD and Körner H (2015) The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended? Cytokine, 72(1): 97-101.

Poon IKA, Baxter AA, Lay FT, Mills GD, Adda CG, Payne JAE, Phan TK, Ryan GF, White JA, Veneer PK, van der Weerden NL, Anderson MA, Kvansakul M and Hulett MD (2014) Phosphoinositide-mediated oligomerization of a defensin induces cell lysis, eLife, 3: e01808.

Poon IKA, Goodall KJ, Phipps S, Chow JDY, Pagler EB, Andrews DM, Conlan CL, Ryan GF, White JA, Wong MKL, Horan C, Matthaei KI, Smyth MJ and Hulett MD (2014) Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation, Eur J Immunol., 44(4): 1016-30.

Goodall KJ, Poon IK, Phipps S and Hulett MD (2014) Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4, PLoS One, 9(10): e109596.

Kalra H, Adda CG, Liem M, Ang C-S, Mechler A, Simpson RJ, Hulett MD and Mathivanan S (2013) Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma, Proteomics, 13(22): 3354-64.

Patel KK, Poon IKA, Talbo GH, Perugini MA, Taylor NL, Ralph TJ, Hoogenraad NJ and Hulett MD (2013) New method for purifying Histidine-rich glycoprotein from human plasma redefines its functional properties, IUBMB Life, 65(6): 550-63.

Lay FT, Mills GD, Poon IK, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M and Hulett MD (2012) Dimerization of plant defensin NaD1 enhances its antifungal activity, J Biol Chem., 287(24): 19961-72.

He YQ, Sutcliffe EL, Bunting KL, Li J, Goodall KJ, Poon IK, Hulett MD, Freeman C, Zafar A, McInnes RL, Taya T, Parish CR and Rao S (2012) The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes, Transcription, 3: 130-45.

Lay FT, Veneer PK, Hulett MD* and Kvansakul M* (2012) Recombinant expression and purification of the tomato defensin TPP3 and its preliminary X-ray crystallographic analysis, Acta Crystallogr Sect F Struct Biol Cryst Commun., 68(Pt 3): 85-88.

Ishii H, Hulett MD, Li J, Santiago FS, Parish CR and Khachigian LM (2012) Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1, Intl J Oncol., 40(5): 1575-80.

Lay FT, Mills GD, Hulett MD* and Kvansakul M* (2012) Crystallization and preliminary X-ray crystallographic analysis of the plant defensin NaD1, Acta Crystallogr Sect F Struct Biol Cryst Commun., 68(Pt 1): 85-88.

Xia YY, Sun S, Kuek L-E, Lopata AL, Hulett MD and Mackay GA (2011) Human Mast Cell Line-1 (HMC-1) cells transfected with Fc RI are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production, Int Pharmacol., 11: 1002-11.

Poon IK, Patel KK, Davis DS, Parish CR and Hulett MD (2011) Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma, Blood, 117(7): 2093-101.

Goodall KJ, Poon IK and Hulett MD (2011) Heparanase as a signaling molecule in cancer and inflammation, Inflam Res., 60: 128-29.

*Corresponding and equal senior author.