Hart - Molecular regulation of stem cells and cancer
Dr Adam Hart
Lecturer, College of Science, Health and Engineering
Cancer prevention, early diagnosis and molecular therapies are the research goals that our group passionately pursue. Understanding the genetic changes that transform normal cells into tumour forming cells is the first step in designing new diagnostics and therapeutics for early detection and treatment of cancer.
Our research group is trying to discover the key genes and molecular pathways that regulate stem cells during normal growth and development, and to identify how those genes are re-activated in the adult to cause cancer. We are particularly interested in breast cancer, myeloid leukaemia and germ cell cancers and have published influential research papers describing new molecular markers and candidate therapeutic targets in each of these tumour types.
Our research papers have been cited by more than 1400 independent research studies and we gratefully acknowledge funding received from the National Health and Medical Research Council and the Australian Research Council.
- Molecular regulation of blood development and leukaemia
- Germ cell tumours reveal a population of pluripotent adult stem cells in the testis
- Discovering the molecular switch that re-activates fetal globin to cure beta-thallassaemia
- Tasmanian Devil pluripotent stem cells for research and species preservation