Publications

For a complete list of publications see:
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Research Gate

Greening DW, Ji H, Chen M, Robinson BWS, Dick IM, Creaney J and Simpson RJ (2016) Primary human malignant mesothelioma exosome signature reflects oncogenic cargo, Sci Rep., 6: 32643.

Gopal SK, Greening DW, Zhu HJ, Simpson RJ and Mathias RA (2016) Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis, Sci Rep., 6: 28321

Nguyen HPT, Simpson RJ, Salamonsen LA and Greening DW (2016) Extracellular vesicles in the intrauterine environment: challenges and potential functions, Biol Reprod., Sep 21. pii: biolreprod.116.143503.

Greening DW, Nguyen HP, Evans J, Simpson RJ and Salamonsen LA (2016) Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy: the role of ovarian steroid and pregnancy hormones, J Proteomics, doi: 10.1016/j.jprot.2016.05.026.

Xu R, Greening DW, Takahashi N, Zhu HJ and Simpson RJ (2016) Extracellular vesicle isolation and characterization: toward clinical application, J Clin Invest., 126(4): 1152-62.

Greening DW, Nguyen H, Elgass K, Simpson RJ and Salamonsen LA (2016) Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions, Biol Repro., 94(2): 38, 1-15.

Gopal SK, Greening DW, Hanssen EG, Zhu HJ, Simpson RJ and Mathias RA (2016) Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells, Oncotarget, doi: 10.18632/oncotarget.7573.

Carrasco-Ramírez P, Greening DW, Andrés G, Gopal SK, Martín-Villar E, Renart J, Simpson RJ and Quintanilla M (2016) Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation, Oncotarget, 7(13): 16070-89.

Xu R, Greening DW, Rai A, Ji H, Simpson RJ (2015) Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct, Methods, 87: 11-25

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, Van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Hoen EN, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, Van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A,  Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R and Gho YS (2015) Evpedia: a community web portal for extracellular vesicles research, Bioinformatics, 31(6): 933-39.

Greening DW, Lee ST, Ji H, Simpson R, Rigopoulos A, Murone C, Fang C, Gong S, O'Keefe G and Scott A (2015) Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways, Oncotarget, 6(35): 38166-80.

Greening DW, Gopal SK, Mathias RA, Liu L, Sheng J, Zhu HJ and Simpson RJ (2015) Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression, Sem Cell Dev Biol., 40: 60-71.

Greening DW, Gopal SK, Xu R, Simpson RJ and Chen W (2015) Exosomes and immunoregulation in cancer progression, Sem Cell Dev Biol., 40: 72-81.

Greening DW, Xu R, Ji H, Tauro BJ and Simpson RJ (2015) A protocol for exosome isolation and characterisation: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods, Methods Mol Biol., 1295: 179-209.

Gopal SK, Greening DW, Mathias RA, Ji H, Rai A, Chen M, Zhu HJ and Simpson RJ (2015) YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment, Oncotarget., 6(15): 13718-30.

Xu R, Greening DW, Rai A, Ji H and Simpson RJ (2015) Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct, Methods, pii: dS1046-2023(15)00154-1.

Ji H, Chen M, Greening DW, He W, Rai A, Zhang W and Simpson RJ (2014) Deep sequencing of RNA from three different extracellular vesicle (EV) subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures, PLoS One, 9: e110314.

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, Van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Hoen EN, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, Van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, N ieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R and Gho YS (2015) EVpedia as a resource for extracellular vesicles biology, Bioinformatics, 31(6): 933-39.

Bernhard OK, Greening DW, Barnes TW, Ji H and Simpson RJ (2013) Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma, Biochim Biophys Acta, 1834(11): 2372-79.

Greening DW, Ji H, Kapp EA and Simpson RJ (2013) Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis, Biochim Biophys Acta, 1834(11): 2293-307.

Greening DW, Kapp EA, Ji H, Speed TP and Simpson RJ (2013) Colon tumour secretopeptidome: insights into endogenous proteolytic cleavage events in the colon tumour microenvironment, Biochim Biophys Acta, 1834(11): 2396-407.

Greening DW and Simpson RJ (2013) An updated secretome, Biochim Biophys Acta, 1834(11): 2225.

Ji H, Greening DW, Barnes TW, Lim JW, Tauro BJ, Rai A, Xu R, Adda C, Mathivanan S, Zhao W, Xue Y, Xu T, Zhu HJ and Simpson RJ (2013) Proteome profiling of exosomes derived from human primary and metastatic colorectal cells reveal differential expression of key metastatic factors and signal transduction components, Proteomics, 13(10-11): 1672-86.

Lee ST, Ji H, Greening DW, Speirs RW, Rigopoulos A, Pillay V, Murone C, Vitali A, Stuhler K, Johns TG, Corner GA, Mariadason JM, Simpson RJ and Scott AM (2013) Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts, Growth Factors, 31(5): 154-64.

Tauro BJ, Greening DW, Mathias RA, Mathivanan S, Ji H and Simpson RJ (2013) Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids, Mol Cell Proteomics, 12(3): 587-98.

Tauro BJ, Mathias RA, Greening DW, Gopal SK, Ji H, Kapp EA, Coleman BM, Hill AF, Kusebauch U, Hallows JL, Shteynberg D, Moritz RL, Zhu HJ and Simpson RJ (2013) Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition, Mol Cell Proteomics, 12(8): 2148-59.

Tauro BJ, Greening DW, Mathias RA, Ji H, Mathivavan S, Scott AM and Simpson RJ (2012) Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes, Methods, 56(2): 293-304.

Greening DW and Simpson RJ (2011) Low-molecular weight plasma proteome analysis using centrifugal ultrafiltration, Methods Mol Biol., 728: 109-24.

Greening DW, Sparrow RL and Simpson RJ (2011) Preparation of platelet concentrates, Methods Mol Biol., 728: 267-78.

Mathias RA, Chen Y, Kapp EA, Greening DW, Mathivanan S and Simpson RJ (2011) Triton X-114 phase separation in the isolation and purification of mouse liver microsomal membrane proteins, Methods, 54(4): 396-406.

Sparrow RL, Greening DW and Simpson RJ (2011) A protocol for the preparation of cryoprecipitate and cryodepleted plasma, Methods Mol Biol., 728: 259-65.