Publications

For a complete list of publications see:
ResearcherID

Wang T-T, Zhao Y-L, Peng L-S, Chen N, Chen W, Lv Y-P, Mao F-Y, Zhang J-Y, Cheng P, Li W-H, Teng Y-S, Fu X-L, Yu P-W, Guo G, Luo P, Zhang W-J, Yang L-Y, Zhuang Y and Zou Q-M (2017) Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GMCSF-PD-L1 pathway, Gut, doi: 10.1136/gutjnl-2016-313075.

Davis ID, Quirk J, Morris L, Seddon L, Tai TY, Whitty G, Cavicchiolo T, Ebert L, Jackson H, Browning J, MacGregor D, Wittke F, Winkels G, Alex R, Miloradovic L, Maraskovsky E, Chen W, Cebon J (2017) A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX® in patients with treated cancer and minimal residual disease at high risk of relapse, Immunotherapy, 9: 249-59.

Peng LS, Zhang JY, Teng YS, Zhao YL, Wang TT, Mao FY, Lv YP, Cheng P, Li WH, Chen N, Duan M, Chen W, Guo G, Zou QM and Zhuang Y (2017) Tumor-associated monocytes/macrophages impair NK-cell function via TGFbeta1 in human gastric cancer, Cancer Immunol Res., 5: 248-56.

Wei J, Zanker D, Di Carluccio AR, Smelkinson MG, Takeda K, Seedhom M, Dersh D, Yang N, Jadhav A, Chen W and Yewdell JW (2017) Varied role of ubiquitylation in generating MHC class I peptide ligands, J Immunol., 198: 3835-45.

Chen L, Anthony A, Oveissi S, Huang M, Zanker D, Xiao K, Wu C, Zou Q and Chen W (2017) Broad based CD4+ T cell responses to influenza A virus in a healthy individual that lacks typical immunodominance hierarchy, Front Immunol, 8: 375.

Duan M,Hibbs ML and Chen W (2017) The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis, Immunol Cell Biol., 95: 225-35.

Li L, Duan M, Chen W, Jiang A, Li X, Yang J, Li Z(2017) The spleen in liver cirrhosis: revisiting an old enemy with novel targets, J Translat Med., 15(1):111.

Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD and Poon IKH (2017) Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting, Sci Rep., 6(7): 39846.

Peng L-S, Mao F-Y, Zhao Y-L, Wang T-T, Chen N, Zhang J-Y, Cheng P, Li W-H, Lv Y-P, Teng L-S, Guo G, Luo P, Chen W, Zou Q-M* and Zhuang Y* (2016) Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer, Oncotarget, 7(34): 55222-30.

Hu J*, Chen L*, Yang W,Li B,Sun H, Wei S, He Y, Zhao Z, Yang S,Zou Q, Chen W, Guo H andWu C(2016) Systematic identification of immunodominant CD4+ T cell responses to HpaA in Helicobacter pylori infected individuals, Oncotarget, 7(34): 54380-91.

Vanderven HA, Ana-Sosa-Batiz F, Jegaskanda S, Rockman S, Laurie K, Barr I, Chen W, Wines B, Hogarth PM, Lambe T, Gilbert SC, Parsons MS and Kent SJ (2016) What lies beneath: antibody dependent natural killer cell activation by antibodies to internal influenza virus proteins, EBioMedicine, 8: 277-90.

Duan M,Hibbs ML and Chen W (2016) The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis, Immunol Cell Biol., doi: 10.1038/icb.2016.97.

Chen J*, Duan M*, Zhao Y, Ling F, Xiao K, Li Q, Lu C, Qi W, Zeng Z, Liao M, Liu Y, Chen W (2015) Saikosaponin a inhibits influenza A virus replication and lung immunopathogenesis, Oncotarget, 6(40): 42541-56.

Chinnery HR, Naranjo Golborne C, Leong CM, Chen W, Forrester JV, McMenamin PG (2015) Retinal microglial activation following topical application of intracellular toll-like receptor ligands, Invest Ophthalmol Vis Sci, 56(12): 7377-86.

Chua B, Wong C, Mifsud E, Edenborough K, Tan A, Mercuri F, Rockman S, Chen W, Turner S, Doherty P, Kelso A, Brown L and Jackson D (2015) Inactivated influenza vaccine that provides rapid, innate-mediated protection and subsequent long-term adaptive immunity, mBio,6: e01024.

Duan M, Steinfort D, Smallwood D, Hew M, Chen W, Ernst M, Irving L, Anderson G and Hibbs M (2015) CD11b immunophenotyping identifies inflammatory profiles in mouse and human lungs, Mucosal Immunology, doi: 10.1038/mi.2015.84.

Rautela J, Baschuk N, Slaney CY, Jayatilleke KM, Xiao K, Bidwell BN, Lucas EC, Hawkins ED, Lock P,  Wong CS, Chen W, Anderson RL, Hertzog PJ, Andrews DM, Möller A and Parker BS (2015) Loss of host type-I IFN signaling accelerates metastasis and impairs NK cell anti-tumor function in multiple models of breast cancer, Cancer Immunol Res., 3(11): 1207-17.

Wylie B, Seppanen E, Xiao K, Zemek R, Zanker D, Prato S, Foley B, Hart PH, Krozcek R, Chen W and  Waithman J (2015) Cross-presentation of cutaneous melanoma antigen by migratory XCR1 + CD103 − and XCR1 + CD103 + dendritic cells, Oncoimmunology, 4(8): e1019198.

Zanker D, Otto W, von Bergen M, Chen W and Janina Tomm (2015) Compartment resolved reference map from highly purified naïve, activated, effector, central memory and effector memory CD8+ cells, Proteomics, 15(11): 1808-12.

Zanker D, Quinn K, Waithman J, Lata R, Murphy R, La Gruta N and Chen W (2015) T cells recognizing a 11mer influenza peptide complexed to H-2Db show promiscuity for peptide length, Immunol Cell Biol., 93(5): 500-07.

Klein O, Davis ID, McArthur GA, Haydon A, Parente P, Dimopoulos P, Jackson H, Maraskovsky E, Hopkins W, Stan R, Chen W and Cebon J (2015) Low dose cyclophosphamide enhances antigen-specific CD4+ lymphocyte responses to NY-ESO-1/ISCOMATRIXTM vaccine in patients with advanced melanoma, Cancer Immunol Immunther., 64(4): 507-18.

Chinnery HR, Leong CM, Chen W, Forrester JV and McMenamin PG (2015) TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea, J Leukoc Biol., 97(1): 103-10.

Verdon TJ, Mitchell RJ, Chen W, Xiao K and van Oorschot RA (2015) FACS separation of non-compromised forensically relevant biological mixtures, Forensic Sci Int Genet., 14: 194-200.

Greening DW, Xu R, Gopal SK, Simpson RJ and Chen W (2015) Exosomes and immunoregulation in cancer progression, Semin Cell Dev Biol., 40: 72-81.

Sheng J, Chen W and Zhu H (2015) Immune suppression function of Transforming Growth Factor-β (TGF-β) in human diseases, Growth Factors, 33(2): 92-101.

Zhuang Y, Liu XF, Cheng P, Shi Y, Li BS, Peng LS, Wang TT, Chen N, Li WH, Chen W, Pang KC, Liu T, Guo H, Yang SM, Zhou YY, Zuo XF, Yang HJ, Yang LY, Mao XH, Zhang YJ, Zeng H, Guo G, Tong WD, Tang B, Luo P, Zhang WJ and Zou QM (2014) A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis, Gut, 64(9): 1368-78.

Chen L, Zanker D, Xiao K, Wu C, Zou Q and Chen W (2014) Immunodominant CD4+ T-cell responses to influenza A virus in healthy individuals focus on matrix 1 and nucleoprotein, J Virol., 88(20): 11760-73.

Vella LJ, Pasam A, Dimopoulos N, Andrews M, Knights A, Puaux AL, Louahed J, Chen W, Woods K and Cebon J (2014) MEK inhibition, alone or in combination with BRAF inhibition, effects multiple functions of isolated normal human lymphocytes and dendritic cells, Cancer Res Immunol., 2(4): 351-60.

Peng LS, Zhou YY, Wang TT, Chen N, Cheng P, Li BS, Li, Guo H, Chen W, Zhang Y* and  Zou QM* (2014) Elevated Interleukin-32 expression is associated with Helicobacter pylori-related gastritis, Plos One, 9(3): e88270.

Tan BS, Anaka M, Deb S, Freyer C, Ebert LM, Chueh AC, Al-Obaidi S, Behren A, Jayachandran A, Cebon J, Chen W* and Mariadason JM* (2014) FOXP3 is infrequently expressed in human melanoma and its over-expression inhibits melanoma cell growth, Oncotarget, 5(1): 264-76.

Sarvestani S, Tate M, Moffat J, Jacobi A, Behlke M, Miller A, Beckham S, McCoy C, Chen W, Mintern J, O'Keeffe M, John M, Williams B and Gantier M (2014) Inosine-mediated modulation of RNA sensing by TLR7/8, J Virol., 88(2): 799-810.

Grant EJ, Chen L, Quiñones-Parra S,Pang K, Kedzierska K and Chen W (2014) T Cell immunity to influenza A viruses, Curr Rev Immunol., 34(1): 15-39.

Zanker D and Chen W (2014) Standard and immunoproteasomes show similar peptide degradation specificities, Eur J Immunol., 44(12): 3500-03.

Wei J, Waithman J, Xiao K, Oveissi S and Chen W (2013) Optimizing conditions required for enhanced cross-priming mediated by influenza infection of tumor cells, Immunol Cell Biol., 91(9): 576-82.

Zanker D, Waithman J, Yewdell J and Chen W (2013) Mixed immunoproteasomes function to increase viral peptide diversity and broaden anti-viral TD8+ responses, J Immunol., 191(1): 52-59.

Waithman J, Zanker J, Xiao K, Oveissi S, Wylie B, Ng R, Tögel L and Chen W (2013) Resident CD8+ and migratory CD103+ dendritic cells control CD8+ T cell immunity during acute influenza infection, Plos One, 8(6): e66136.

Komatsu N, Jackson HM, Chan KF, Oveissi S, Cebon J, Itoh K and Chen W (2013) Fine-mapping naturally accruing NY-ESO-1 antibody epitopes in melanoma patients' sera using short overlapping peptides and full-length recombinant protein, Mol Immunol., 54(3-4): 465-71.

Grant E*, Wu C*, Chan KF, Eckle S, Bharadwaj M, Zou QM, Kedzierska K and Chen W (2013) Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T cell responses, Immunol Cell Biol., 91(2): 184-94.

Chen L, Li B, Yang W, He J, Li N, Hu J, He Y, Yu S, Zhao Z, Luo P, Zhang J, Lu D, Li H, Guo H, Yang S, Guo G, Mao X, Chen W*, WuC* and Zou Q* (2013) A dominant CD4+ T-cell response to Helicobacter pylori is associated with decreased risk of gastric diseases in Chinese, Gastroeterology, 144(3): 591-600.

Luciani F, Sanders MT, Oveissi S, Pang KC and Chen W (2013) Increasing viral dose causes a reversal in CD8+ T cell immunodominance during primary influenza infection due to differences in Ag presentation, T cell avidity and precursor numbers, J Immunol., 190(1): 36-47.

Zanker D, Xiao K, Oveissi S, Guillaume P, Luescher IF and Chen W (2012) An optimized method for establishing high purity murine CD8(+) T cell cultures, J Immunol Methods, 387(1-2): 173-80.

Klein O*, Ebert LM*, Zanker D*, Woods K, Tan BS, Fucikova J, Behren A, Davis ID, Maraskovsky E, Chen W and Cebon J (2012) Flt3 ligand expands CD4(+) FoxP3(+) regulatory T cells in human subjects, Eur J Immunol., 43(2): 533-39.

Ebert LM, Macraild SE, Zanker D, Davis ID, Cebon J and Chen W (2012) A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma, PLoS One, 7(10): e48424.

Zhao RY*, Mifsud NA*, Xiao K*, Chan KF, Oveissi S, Jackson HM, Dimopoulos N, Guillaume P, Knights AJ, Lowen T, Robson NC, Russell SE, Scotet E, Davis ID, Maraskovsky E, Cebon J, Luescher IF and Chen W (2012) A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen, PLoS One, 7(9): e44707.

Liu T, Peng L, Yu P, Zhao Y, Shi Y, Mao X, Chen W, Cheng P, Wang T, Chen N, Zhang J, Liu X, Li N, Guo G, Tong W, Zhuang Y and Zou Q (2012) Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer, J Clin Immunol., 32(6): 1332-29.

Zhuang Y*, Peng LS*, Zhao YL*, Shi Y, Mao XH, Chen W, Pang KC, Liu XF, Liu T, Zhang JY, Zeng H, Liu KY, Guo G, Tong WD, Shi Y, Tang B, Li N, Yu S, Luo P, Zhang WJ, Lu DS, Yu PW and Zou QM (2012) CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer, Gastroenterology, 143(4): 951-62.

Zhuang Y, Peng LS, Zhao YL, Shi Y, Mao XH, Guo G, Chen W, Liu XF, Zhang JY, Liu T, Luo P, Yu PW and Zou QM (2012) Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival, Cancer Immunol Immunother., 61(11): 1965-75.

Tan B, Behren A, Anaka M, Vella L, Cebon J, Mariadason JM* and Chen W* (2012) FOXP3 is not mutated in human melanoma, Pigment Cell Melanoma Res., 25(3): 398-400.

John T*, Yanagawa N*, Kohler D*, Craddock KJ*, Bandarchi-Chamkhaleh B, Pintilie M, Sykes J, To C, Li M, Panchal D, Chen W, Shepherd FA and Tsao MS (2012) Characterization of lymphomas developing in immunodeficient mice implanted with primary human non-small cell lung cancer, Thorac Oncol., 7(7): 1101-08.

Ebert LM, MacRaild SE, Davis ID, Cebon J and Chen W (2012) A novel method for detecting antigen-specific human regulatory T cells, J Immunol Methods, 377(1-2): 56-61.

Kupz A, Guarda G, Gebhardt T, Sander LE, Short KR, Diavatopoulos DA, Wijburg OL, Cao H, Waithman JC, Chen W, Fernandez-Ruiz D, Whitney PG, Heath WR, Curtiss R 3rd, Tschopp J, Strugnell RA and Bedoui S (2012) NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells, Nat Immunol., 3(2): 162-69.

Vareki SM, Harding MJ, Waithman J, Zanker D, Shivji AN, Rytelewski M, Mazzuca DM, Yekta MA, Chen W, Schell TD and Haeryfar SMM (2012) Differential regulation of simultaneous anti-tumor and alloreactive CD8+ T cell responses in the same host by rapamycin, Am J Transplant., 12(1): 233-39.

Nicholaou T, Chen W, Davis ID, Jackson HM, Dimopoulos N, Barrow C, Browning J, Macgregor D, Williams D, Hopkins W, Maraskovsky E, Venhaus R, Pan L, Hoffman EW, Old LJ and Cebon J (2011) Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIX™, Cancer Immunol Immunother., 60(11): 1625-37.

Wu C, Zanker D, Valkenburg S, Tan B, Kedzierska K, Zou QM, Doherty PC and Chen W (2011) Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals, Proc Natl Acad Sci USA, 108(22): 9178-83.

Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, Uematsu S, Akira S, Robertson SA, Brown MP and Hayball JD (2011) Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition, J Virol., 85(7): 3385-96.

Klein O, Schmidt C, Knights A, Davis ID, Chen W and Cebon J (2011) Melanoma vaccines: developments over the past 10 years, J Expert Rev Vacc., 10(6): 853-73.

*Contributed equally to work.