Identifying housekeeping roles for the immunoproteasome
The proteasome is a critical part of the degradation and recycling machinery within the cell. A specialized isoform of this protein, known as the immunoproteasome, is present in antigen presenting cells and postulated to be the source of superior immunogenic peptides for anti-viral immunity.
We have identified immunoproteasomes in non-antigen presenting cells and certain types of cancers which also express increased levels of the immunoproteasome. We now aim to characterize the interactions of different proteasome/ immunoproteasome isoforms with specialized proteins on a global level and define the pro-survival pathways dysregulated in immunoproteasome overexpressed cancer cells, with the ultimate goal of finding novel therapies for specialised cancer types.