Chen - T cell immunology
Professor Weisan Chen
Professor, College of Science, Health and Engineering
Our lab specialises in CD8+ T cell biology and antigen processing and presentation, especially in relation to the development of cross-protective immune responses to the influenza virus.
Our research activities are divided between human T cell research (identification of mechanisms generating immunodominant human anti-influenza CD8+ T cells and CD8+ T cell epitopes for common HLA molecules expressed within the Australian population) and mouse models of influenza virus infection.
These projects investigate the interactions between T cells and antigen-presenting cells, macrophages and monocytes and their impact on the severity of influenza induced lung pathogenesis. As part of the NHMRC Influenza program (2014-19), our lab uses its knowledge of innate versus adaptive immune
cell interactions and antigen processing, presentation and epitope selection to:
(1) aid the development of a universal T cell-based vaccine to the influenza virus and
(2) elucidate the host immune cell factors governing influenza infection severity.
- Investigating the role of defective ribosomal products in influenza induced immune responses
- Investigating the role of macrophage and monocyte heterogeneity in influenza induced lung pathogenesis
- Investigating the distinct requirements of ′peptide-receptive′ H-2KK molecules
- Identifying housekeeping roles for the immunoproteasome